We offer training opportunities for clinical and non-clinical students. Below are all the projects that are or were supported by the Centre with a non-clinical or intercalated studentship or a clinical research fellowship (including studentships from the former Imperial Centre)
2024
Non-clinical studentships
Exploiting 3D in vitro models to advance diffusion magnetic resonance imaging (MRI) as a probe of cellular and tumour microstructure - Dr Jessica Winfield (Royal Marsden) , Dr Paula Cunnea (Department of Surgery & Cancer, Imperial College London), Professor Simon Robinson and Professor Christina Messiou (Division of Radiotherapy & Imaging, The ICR)
Morphological phenotyping of the ccRCC TME using Deep Learning and Morphometrics - Professor Samra Turajilic (Division of Clinical Studies, The ICR), Dr Guang Yang (Department of Bioengineering, Imperial College London), and Professor James Larkin (Division of Clinical Studies, The ICR)
Super-resolution microscopy to investigate epigenetic evolution in ovarian high grade serous carcinoma - Professor Jessica Downs (Division of Cancer Biology, The ICR), Professor Iain McNeish (Department of Surgery & Cancer, Imperial College London) and Professor Paul French (Department of Physics, Imperial College London)
MB-PhD studentships
An artificial intelligence-based approach to identify immunologic predictors of outcome to immunotherapy in hepatocellular cancer using digital pathology - Dr David Pinato (Department of Surgery & Cancer, Imperial College London), Dr Wenjia Bai (Department of Brain Sciences, Imperial College London), and Dr Francesco Mauri (Department of Surgery & Cancer, Imperial College London)
Remodelling the tumour immune microenvironment in neuroblastoma by inhibiting RNA splicing - Dr Anke Nijhuis (Department of Surgery & Cancer, Imperial College London), Professor Louis Chesler (Division of Clinical Studies, The ICR), and Professor Hector Keun (Department of Surgery & Cancer, Imperial College London)
Cancer microfluidic modelling for geometric and therapeutic translation - Dr Stefan Antonowicz (Department of Surgery & Cancer, Imperial College London), Professor Daniele Dini and Dr Tian Yuan (Department of Mechanical Engineering, Imperial College London)
Understanding the response to treatment in homologous recombination defective breast cancer by functional profiling of circulating tumour cell clusters - Professor Christopher Lord (Division of Breast Cancer Research, The ICR), Dr Sam Au (Department of Bioengineering, Imperial College London), Professor Andrew Tutt and Dr Stephen Pettitt (Division of Breast Cancer Research, The ICR)
Clinical research fellowships
Discovering, developing, and delivering, novel therapeutic strategies for MEK/ERK/RSK activated lethal prostate cancer - Dr Navita Somaiah (Division of Radiotherapy & Imaging, The ICR), Professor Trevor Graham (Division of Molecular Pathology, The ICR), Professor Alan Melcher (Division of Radiotherapy & Imaging, The ICR), Dr Anita Grigoriadis (Division of Breast Cancer Research, The ICR), Dr Tom Lund (Division of Molecular Pathology, The ICR), Dr Luis Zapata Ortiz (Division of Molecular Pathology, The ICR)
Understanding the impact of radiotherapy on the nodal immune microenvironment and cross-talk with the primary tumour in breast cancer - Dr Adam Sharp (Division of Clinical Studies, The ICR), Professor Udai Banerji (Division of Cancer Therapeutics, The ICR), Professor Johann De Bono (Division of Clinical Studies, The ICR), Dr Jon Welti (Division of Clinical Studies, The ICR), Dr Marco Bezzi (Division of Molecular Pathology, The ICR), Dr Juan Jimenez Vacas (Division of Clinical Studies, The ICR)
Novel liquid biopsies to guide treatment in recurrent/metastatic head and neck cancer - Dr Ben O'Leary (Division of Radiotherapy & Imaging, The ICR), Professor Jyoti Choudhary (Division of Cancer Biology, The ICR), and Dr Annie Baker (Division of Molecular Pathology, The ICR)
Immune derived volatile biomarkers in oesophagogastric cancer - Professor Jessica Strid (Department of Immunology and Inflammation, Imperial College London), Professor George Hanna (Department of Surgery & Cancer, Imperial College London) and Dr Sam Au (Department of Bioengineering, Imperial College London)
Developing transcription inhibitors as a new class of cancer therapeutics - Professor Simak Ali (Department of Surgery & Cancer, Imperial College London) and Professor Laki Buluwela (Department of Surgery & Cancer, Imperial College London)
2023
Non Clinical Studentships
Resolving the isoform-specific signalling of RSK1 and RSK4 in non-small cell lung cancer through combined artificial intelligence and molecular biology - Dr Olivier Pardo, Dr Kirill Veselkov and Professor Michael Seckl (Imperial, Surgery and Cancer) & Dr Paul Huang (ICR, Molecular Pathology).
Fluorescent nanoparticle arrays for label-free monitoring of immunotherapy for bladder cancer - Professor Molly Stevens (Imperial, Materials) & Dr Anna Wilkins (ICR, Radiotherapy & Imaging)
Novel p21-disrupting peptides to prevent quiescence and resistance to chemotherapy - Dr Anna Barnard (Imperial, Chemistry), Dr Alexis Barr (MRC-LMS, Institute of Clinical Sciences) & Dr Basil Greber (ICR, Structural Biology)
Development of novel dual-target agents to treat neuroblastoma that combine selective protein degradation with synergistic inhibition - Professor Louis Chesler (ICR, Clinical Studies), Professor Matt Fuchter (Imperial, Chemistry), Professor Hector Keun& Dr Anke Nijhuis (Imperial, Surgery & Cancer)
An explant-in-chip platform to study immune-cancer cell interactions and enhance tumour immunogenicity ex vivo: A focus on radiotherapy - Professor Darryl Overby (Imperial, Bioengineering) &Professor Alan Melcher (ICR, Radiotherapy & Imaging)
Unravelling the role of cancer associated fibroblasts in cancer evolution and drug resistance using microfluidics - Dr Sam Au (Imperial, Bioengineering) & Professor Udai Banerji (ICR, Cancer Therapeutics)
MB-PhD Studentships
Targeted in-tumour chemotherapeutic delivery via electrophoretic release from conductive elastomer-based materials - Professor Amin Hajitou (Imperial, Brain Sciences), Dr Juanita Lopez (Royal Marsden Hospital) & Professor Rylie Green (Imperial, Bioengineering)
Winners versus Losers: Deciphering the mechanism of cell competition via optogenetics and single cell tracking of organoids - Professor Pascal Meier (ICR, Breast Cancer Research), Dr Periklis Pantazis & Dr Chris Rowlands (Imperial, Bioengineering)
Organ-on-chip platforms for investigating the influence of extracellular matrix components on tumour cell invasion from patient-derived lung explants - Dr Sam Au (Imperial, Bioengineering) & Dr Paul Huang (ICR, Molecular Pathology).
2021
Non-clinical studentships
RNA barcodes for high-dimensional functionalization of cancer heterogeneity - Professor Zoltan Takats(Imperial, Metabolism, Digestion & Reproduction) & Dr Marco Bezzi (ICR, Molecular Pathology).
Engineering next generation laminin targeted cancer immunotherapy - Dr Paul Huang (ICR, Molecular Pathology) & Dr Jun Ishihara (Imperial, Bioengineering)
Accelerating volumetric MR Imaging for Real-Time Adaptive Radiotherapy - Dr Andreas Wetscherek (ICR, Radiotherapy & Imaging) & Professor Wayne Luk (Imperial, Computing).
Spatial and temporal high resolution quantitative live imaging techniques to determine mechanisms of chromosomal instability and drug resistance in breast cancer patient-derived organoids - Professor Jorge Bernardino de la Serna (Imperial, National Heart & Lung Institute) & Professor Andrew Tutt (ICR, Breast Cancer Research)
MB-PhD studentships
A Point-of-Care Diagnostic Device for Early Oncogene Detection in Cancer - Dr Ali Yetisen (Imperial, Chemical Engineering) & Professor Louis Chesler (ICR, Clinical Studies)
Improving endometrial cancer diagnosis via detection of microRNA biomarkers from liquid biopsies: From biomarker discovery to screening test engineering -Dr Sylvain Ladame (Imperial, Bioengineering) & Professor Sadaf Ghaem-Maghami (Imperial, Surgery & Cancer)
Bioengineering tumor-targeted cytokines or chemotherapy for effective, specific and personalised immunotherapy combinations in pancreatic cancer -Dr Anguraj Sadanandam (ICR, Molecular Pathology) & Dr Jun Ishihara (Imperial, Bioengineering)
Novel Bio-Chips for real-time detection of acidification in the tumour microenvironment - Professor Pantelis Georgiou (Imperial, Electrical and Electronic Engineering) & Professor Chris Bakal (ICR, Cancer Biology)
Combined functional MRI and super-resolution ultrasound for non-invasive monitoring of tumour blood delivery during breast cancer radiotherapy - Professor Mengxing Tang (Imperial, Bioengineering), Dr Navita Somaiah (ICR, Radiotherapy & Imaging).
Magnetic Resonance detection of functionalized extracellular vesicles to understand⯠their role in breast cancer development and metastasis formation - Professor Simon Robinson (ICR, Radiotherapy & Imaging) & Professor Molly Stevens (Imperial, Materials).
Synthetic lethality driven by N-myristoyltransferase inhibition: a convergence approach to target MYCN-driven childhood cancers - Professor Ed Tate (Imperial, Chemistry) & Professor Louis Chesler (ICR, Clinical Studies).
New formulations of anti-cancer drugs for targeted treatment of triple negative breast cancer - Professor Chris Lord (ICR, Breast Cancer Research) & Professor Alex Porter (Imperial, Materials).
Developing a point-of-care diagnostic technology for ovarian cancer detection - Mr Srdjan Sasso (Imperial, Department of Metabolism, Digestion and Reproduction) & Professor Molly Stevens (Imperial, Materials).
2019
Non-clinical studentships (ICR-Imperial)
Microfluidic Based Reactions with [18F]Fluoroform: A Toolbox for Next Generation 18F-Radiolabelled Medicinal Chemistry Compounds - Dr Gabriela Kramer-Marek (ICR, Radiotherapy & Imaging) & Dr Philip Miller (Imperial, Chemistry)
Biomechanical activation of pro-metastatic programs in circulating tumour cells by vasculature constriction forces - Professor Chris Bakal(ICR, Cancer Biology) & Dr Sam Au (Imperial, Bioengineering)
Dataflow computing for continuous realtime adaptive radiotherapy - Professor Uwe Oelfke (ICR, Radiotherapy & Imaging) & Professor Wayne Luk (Imperial, Computing)
Development of MRI brain tumour fingerprinting for clinical assessment of brain tumour biology - Professor Dow-Mu Koh (Royal Marsden Hospital) & Dr Matthew Grech-Sollars (Imperial, Surgery & Cancer)
Understanding systems and molecular mechanisms underlying cancer immunotherapy for the development of precision immunotherapy with informed strategies - Dr Masahiro Ono (Imperial, Life Sciences) & Professor Alan Melcher (ICR, Radiotherapy & Imaging)
Investigating the roles of the proteasome vs. autophagy, two major protein degradation pathways, in degradation and stabilisation of the proteome of ovarian high-grade serous carcinoma (HGSC) - Professor Jyoti Choudhary (ICR, Cancer Biology) & Dr Tolga Bozkurt (Imperial, Life Sciences)
Non-clinical studentships (Imperial)
Exploring PARP biology and therapy response via metabolic flux analysis and a novel chemical proteomics workflow - Professor Hector Keun(Imperial, Surgery & Cancer) , Professor Ed Tate & Dr Adrian Benito Mauricio (Imperial, Chemistry).
Hyperspectral Circumferential Resection Margin Assessment for Gastrointestinal Cancer Surgery - Professor Dan Elson & Mr Christopher Peters (Imperial, Surgery & Cancer)
2018
Non-clinical studentships (ICR-Imperial)
Nanotopographical effects on transcriptional regulation and nuclear morphology to inform strategies against cancer - Professor Molly Stevens (Imperial, Materials) & Professor Chris Bakal (ICR, Cancer Biology)
A chemical proteomic platform to uncover the impact of dynamic protein S-acylation in cancer - Professor Ed Tate (Imperial, Chemistry) & Professor Julian Downward (ICR)
Ultrasound backscatter assessment of tumour response to radiotherapy using finite element model-based attenuation and diffraction corrections - Dr Emma Harris (ICR, Radiotherapy & Imaging) & Dr Peter Huthwaite (Imperial, Mechanical Engineering).
Short-pulse ultrasound delivery of chemotherapeutic agents across the blood-brain barrier for the treatment of paediatric high grade glioma - Professor Gail Ter Haar (ICR, Radiotherapy & Imaging) & Dr James Choi (Imperial, Bioengineering)
Studentships (Imperial)
Studying electronic activity wearable monitors for high-grade gliomas (HGG) patients undergoing chemo-radiotherapy - Dr Matthew Williams (Imperial, Surgery & Cancer) and Professor Francesca Toni (Imperial, Computing)
Automated sampling of cell-free DNA from blood using engineered hydrogel-filled nanopores: Improving diagnostic/prognostic tests for prostate cancer - Professor Charlotte Bevan (Imperial Surgery & Cancer),Professor Joshua Edel (Imperial, Chemistry) & Dr Sylvain Ladame (Imperial, Bioengineering).
Novel adjuvants for antibody-based cancer therapeutics: design, biological characterisation and influence on membrane-protein structure - Dr Doryen Bubeck (Imperial, Life Sciences) & Professor Ed Tate (Imperial, Chemistry)
2017
Studentships (Imperial)
Real time precision phenotyping of significant polyps and early colorectal cancers using rapid evaporative ionisation mass spectrometry (REIMS) - Mr James Kinross and Professor Ara Darzi (Imperial, Surgery & Cancer) & Professor Zoltan Takats (Imperial, Metabolism, Digestion & Reproduction)
Unlocking the KLK activome in drug-resistant cancer: imaging, biomarkers and target validation using novel activity probes - Professor Ed Tate (Imperial, Chemistry), Professor Eric Aboagye (Imperial, Surgery & Cancer) & Professor Charlotte Bevan (Imperial Surgery & Cancer).
Optimisation of colorectal cancer screening and prevention: risk factors for proximal colon cancer and screening of a high-risk population - Professor Amanda Cross (Imperial, Surgery & Cancer)
Before 2016
Studentships (Imperial)
Investigating lactate metabolism in cancer and its therapeutic implications - Professor Hector Keun and Professor Eric Aboagye(Imperial, Surgery and Cancer)
Epigenetic mechanisms of breast cancer prevention by the Type II diabetes mellitus agent metformin - Dr James Flanagan (Imperial, Surgery and Cancer) and Professor Mark Gunter (Imperial, SPH)
Novel chemical proteomics approaches to study N-myristoylation and N-terminal methionine excision - Professor Ed Tate (Imperial, Chemistry)
RSK4 targeting: a new therapeutic strategy against both drug resistance and metastasis in lung cancer - Professor Michael Seckl, Dr Olivier Pardo & Dr Filippo Prischi (Imperial, Surgery and Cancer)
Understanding the mechanisms of action of estrogen receptor mutations in metastatic breast cancer - Professor Simak Ali and Professor Laki Buluwela(Imperial, Surgery and Cancer)