Human cancer organoids and other 3D cancer models retain important aspect of the original cancer including cellular functional heterogeneity and patient-specific differential responses to treatments, both a requirement for personalised cancer medicine.

 


Qatar Complex Fluids Laboratory with Confocal laser scanning microscope equipment with display of 2D High resolution confocal images of carbonate rocks

Our first focus is on developing 3D models for human cancer types that are challenging to derive and grow by improving methodologies. We wish to optimise the growth of organoids by controlling their extracellular environment, leveraging our strength in chemical biology and material science to generate novel media and 3D polymer combinations. We will establish novel co-cultures methods to recapitulate the tumour microenvironment, combining tumour cells with stromal and immune cells. Using our bioengineering and fluid mechanics expertise, we will recapitulate tumour environmental features, which is a prerequisite to better understand tumour biology, physical interactions and forces, and to understand treatment responses. Finally, we wish to develop tools and technologies that enhance the experimental scale and throughput of organoids, such as drug screening pipelines, bespoke high-content imaging platforms allowing large-scale 3D imaging, and new mathematical and computational approaches for analysis.