This page contains the list of publications which have been supported by the CRUK Convergence Science Centre (incl. non-clinical and clinical studentships programmes) as well as by the previous Imperial and ICR CRUK centres (now part of the Convergence Science Centre)

Bold text highlights authors supported by the Centre.  

#ClinInfra - Supported by our investment in Clinical Infrastructure at the ICR and Imperial 

#DataSciInfra - Supported by our investment in Data Science Infrastructure at the ICR

#CanTechCat - Supported by our Cancer Technology Catalyst team 

#OtherInfra - Supported by other investments at the ICR and Imperial (e.g. Human Organoid Facility, Microfabrication & Prototyping Facility, Equipment...) 

#NonClinStud  - Supported by our Non-Clinical Studentship programme 

#CATP - Supported by our Clinical Academic Training Programme 

#Affiliation - Authors directly affiliated to the Centre

2024

Elucidating acquired PARP inhibitor resistance in advanced prostate cancer - Cancer Cell. 2024 Nov 14:S1535-6108(24)00403-3.

Seed G, Beije N, Yuan W, Bertan C, Goodall J, Lundberg A, Tyler M, Figueiredo I, Pereira R, Baker C, Bogdan D, Gallagher L, Cieslik JP, Greening S, Lambros M, Neves R, Magraner-Pardo L, Fowler G, Ebbs B, Miranda S, Flohr P, Bianchini D, Rescigno P, Porta N, Hall E, Gurel B, Tunariu N, Sharp A, Pettit S, Stoecklein NH, Sandhu S, Quigley D, Lord CJ, Mateo J, Carreira S, de Bono J. 

#ClinInfra

Repeatability of quantitative MR fingerprinting for T1 and T2 measurements of metastatic bone in prostate cancer patients - Eur Radiol. 2024 Nov 6.

Rata M, Orton MR, Tunariu N, Curcean A, Hughes J, Scurr E, Blackledge M, d'Arcy J, Jiang Y, Gulani V, Koh DM.

#ClinInfra

Imaging PD-L1 in the brain-Journey from the lab to the clinic - Neuro Oncol. 2024 Oct 28:noae190.

Dar D, Rodak M, Da Pieve C, Gorczewska I, Sharma G, Chmielik E, Niedbala M, Bzowski P, d'Amico A, Bobek-Billewicz B, Nowicka E, Tarnawski R, Kaspera W, Kramer-Marek G.

#NonClinStud

Safety and efficacy of itacitinib, a selective JAK1 inhibitor, in advanced hepatocellular cancer: Phase 1b trial (JAKAL) - Future Oncol. 2024 Sep 16:1-9. doi: 10.1080/14796694.2024.2396795.

Troiani A, Martinez M, Ward C, Benartzi CW, Pinato DJ, Sharma R. 

#ClinlInfra

Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer - Cancer Cell. 2024 Sep 16:S1535-6108(24)00317-9.

Calì B, Troiani M, Bressan S, Attanasio G, Merler S, Moscarda V, Mosole S, Ricci E, Guo C, Yuan W, Gallagher L, Lundberg A, Bernett I, Figueiredo I, Arzola RA, Abreut EB, D'Ambrosio M, Bancaro N, Brina D, Zumerle S, Pasquini E, Maddalena M, Lai P, Colucci M, Pernigoni N, Rinaldi A, Minardi D, Morlacco A, Moro FD, Sabbadin M, Galuppini F, Fassan M, Rüschoff JH, Moch H, Rescigno P, Francini E, Saieva C, Modesti M, Theurillat JP, Gillessen S, Wilgenbus P, Graf C, Ruf W, de Bono J, Alimonti A. 

#ClinInfra

PoLambRimetry: a multispectral polarimetric atlas of lamb brain - J Biomed Opt. 2024 Sep;29(9):096002.

Mieites V, Anichini G, Qi J, O'Neill K, Conde OM, Elson DS. 

#OtherInfra

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer - Oncogene. 2024 Sep 13. doi: 10.1038/s41388-024-03148-4. Epub ahead of print. PMID: 39266679.

Sardar S, McNair CM, Ravindranath L, Chand SN, Yuan W, Bogdan D, Welti J, Sharp A, Ryan NK, Knudsen LA, Schiewer MJ, DeArment EG, Janas T, Su XA, Butler LM, de Bono JS, Frese K, Brooks N, Pegg N, Knudsen KE, Shafi AA. 

#ClinInfra

BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity - J Clin Invest. 2024 Sep 17;134(18):e179998.

Westaby D, Jiménez-Vacas JM, Figueiredo I, Rekowski J, Pettinger C, Gurel B, Lundberg A, Bogdan D, Buroni L, Neeb A, Padilha A, Taylor J, Zeng W, Das S, Hobern E, Riisnaes R, Crespo M, Miranda S, Ferreira A, Hanratty BP, Nava Rodrigues D, Bertan C, Seed G, Fenor de La Maza MLD, Guo C, Carmichael J, Grochot R, Chandran K, Stavridi A, Varkaris A, Stylianou N, Hollier BG, Tunariu N, Balk SP, Carreira S, Yuan W, Nelson PS, Corey E, Haffner M, de Bono J, Sharp A.

#CATP #ClinInfra

Recent Electrochemical Advancements for Liquid-Biopsy Nucleic Acid Detection for Point-of-Care Prostate Cancer Diagnostics and Prognostics - Biosensors. 2024; 14(9):443.

Broomfield J, Kalofonou M, Bevan CL, Georgiou P. 

#NonClinStud 

YAP activation is robust to dilution - Mol Omics. 2024 Sep 16.

Jones I, Arias-Garcia M, Pascual-Vargas P, Beykou M, Dent L, Chaudhuri TP, Roumeliotis T, Choudhary J, Sero J, Bakal C. 

#NonClinStud

Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology - Nat Genet. 2024 Sep;56(9):1868-1877. 

Kinnersley B, Sud A, Everall A, Cornish AJ, Chubb D, Culliford R, Gruber AJ, Lärkeryd A, Mitsopoulos C, Wedge D, Houlston R.

#DataSciInfra

DrugSynthMC: An Atom-Based Generation of Drug-like Molecules with Monte Carlo Search - J Chem Inf Model. 2024 Sep 9.

Roucairol M, Georgiou A, Cazenave T, Prischi F, Pardo OE. 

#OtherInfra

Super-resolved fluorescence imaging utilising accessible stochastic optical reconstruction microscopy (easySTORM) implemented on a low-cost, modular open-source (openFrame) microscope - Measurement Science and Technology. 2024 Sept 2.

Anupam Bharadwaj, Amalesh Kumar, Ranjan Kalita, Rumela Mitra, Amit Sharma, Bithiah G. Jaganathan, Jina Bhattacharyya, Anupam Sarma, Edwin Garcia, Bosanta R. Boruah, Sunil Kumar, Jonathon Lightley, Yuriy Alexandrov, Christopher Dunsby, Mark Neil, and Paul M. W. French

#DevFund

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant - Cancer Cell. 2024 Aug 27:S1535-6108(24)00305-2.

Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundström E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schüller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG.

#ClinInfra

A Topological Gaussian Mixture Model for Bone Marrow Morphology in Leukaemia - Arxiv [Preprint]. 24 Aug 2024.

Qiquan Wang, Anna Song, Antoniana Batsivari, Dominique Bonnet, Anthea Monod

#NonClinStud

Technologies and techniques to improve precision in breast conserving surgery -  J Surg Oncol. 2024 Aug 21.

Pitfalls and challenges of peptide nucleic acid immobilisation on carbon surfaces for sequence-specific capturing of nucleic acid biomarkers - Biosens Bioelectron. 2024 Aug 3;264:116634.

Meng X, Petrou L, Kenaan A, Khan D, O'Hare D, Ladame S.

#CATP

Commentary: The North West London Clinical Trials Alliance: efficiency and innovation in clinical trial delivery - Trials. 2024 Jul 29;25(1):509.

Kierkegaard P, Su B, Wong R, Boffito M, Balendra S. 

#CanTechCat

Injectable conductive hydrogel electrodes for minimally invasive neural interfaces - J. Mater. Chem. B, 2024.

Kusen Ines; Lee, Aaron; Cuttaz, Estelle; Bailey, Zachary K; Killilea, Joshua; Merlo-Nikpay Aslie, Shirine; Goding, Josef; Green, Rylie.

#CATP

Prospective Study of Non-Contrast, Abbreviated MRI for Hepatocellular Carcinoma Surveillance in Patients with Suboptimal Hepatic Visualisation on Ultrasound - Cancers. 2024; 16(15):2709.

Vithayathil M, Qurashi M, Vicente PR, Alsafi A, Naik M, Graham A, Khan S, Lewis H, Dhar A, Smith B, Selvapatt N, Manousou P, Possamai L, Izadi H, Lim A, Tait P, Sharma R.

#CATP

Stability for Inference with Persistent Homology Rank Functions - Computer Graphics Forum, 43: e15142.

Wang, Q., García-Redondo, I., Faugère, P., Henselman-Petrusek, G. and Monod, A.

#NonClinStud

Opportunities and Challenges in Soft Tissue Sarcoma Risk Stratification in the Era of Personalised Medicine - Curr Treat Options Oncol. 2024 Jul 30.

Chowdhury A, Thway K, Pasquali S, Callegaro D, Gronchi A, Jones RL, Huang PH.

#CATP

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis - Oncogene. 2024 Jul 25.

Leslie TK, Tripp A, James AD, Fraser SP, Nelson M, Sajjaboontawee N, Capatina AL, Toss M, Fadhil W, Salvage SC, Garcia MA, Beykou M, Rakha E, Speirs V, Bakal C, Poulogiannis G, Djamgoz MBA, Jackson AP, Matthews HR, Huang CL, Holding AN, Chawla S, Brackenbury WJ.

#NonClinStud

Synthesis and Functionalization of Biodegradable Second Harmonic Generation Nanoprobes for Cell Targeting - Curr Protoc. 2024 Jul;4(7):e1089. doi: 10.1002/cpz1.1089. PMID: 39034855.

Ulucay E, Bollier P, Spilioti M, Sonay AY, Kalyviotis K, Pantazis P. 

#CATP

Simulation of ultrasound backscatter coefficient measurement using the finite element method - Ultrasonics. July 2024,107394, ISSN 0041-624X.

George West, Stewart Haslinger, Jeffrey Bamber, Michael Lowe, Peter Huthwaite, Emma Harris

#NonClinStud

Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer - Nat Cancer. 2024 Jul 12. doi: 10.1038/s43018-024-00787-0. Epub ahead of print. PMID: 38997466.

Fernandez-Mateos J, Cresswell GD, Trahearn N, Webb K, Sakr C, Lampis A, Stuttle C, Corbishley CM, Stavrinides V, Zapata L, Spiteri I, Heide T, Gallagher L, James C, Ramazzotti D, Gao A, Kote-Jarai Z, Acar A, Truelove L, Proszek P, Murray J, Reid A, Wilkins A, Hubank M, Eeles R, Dearnaley D, Sottoriva A. 

#CATP #DataSciInfra

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance - Nature. 2024 Jul 3.

Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A*, Yin D*, Zhang C*. 

#Affiliation

G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer - bioRxiv [Preprint]. 2024 June 28:2024. 06. 24 .600010.

Jenna Robinson*, Gem Flint*, Ian Garner, Silvia Galli, Thomas E. Maher, Marina K. Kuimova, Ramon Vilar, Iain A. McNeish, Robert Brown, Hector Keun, Marco Di Antonio

#NonClinStud

Evaluating prostate cancer bone metastases response with whole-body MRI: What we know and still need to know - Eur Radiol. 2024 Jun 20.

Padhani AR, Tunariu N, Perez-Lopez R, Tombal B, Lecouvet FE. 

#ClinInfra

Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells - Sci Rep. 2024 Jun 26;14(1):14793.

Perea Paizal J, Au SH, Bakal C

#NonClinStud

Stereotactic Body Radiotherapy for Oligoprogression in Castration-Resistant Prostate Cancer: Early Toxicity Analysis of the TRAP Trial - Clin Oncol (R Coll Radiol). 2024 Jun.

Patel PH, Dreibe S, Reid A, Parker C, Murray J, Pathmanathan A, Tirona A, Guevara J, Suh YE, Frew J, Palaniappan N, Syndikus I, Attard G, Tunariu N, Tree AC. 

#ClinInfra

Multispectral Mueller matrix imaging: a potential tool to visualize white matter tracts - Proc. SPIE 13010, Tissue Optics and Photonics III, 130100G (18 June 2024).

Verónica Mieites, Giulio Anichini, Ji Qi, Kevin O'Neill, Olga M. Conde, and Daniel S. Elson

#OtherInfra

Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biosensors and Bioelectronics 262 (2024) 116513.

Capturing longer term surgical outcome measures as part of routine care of breast cancer patients - Breast. 2024 Jun 5;76:103758.

Leusink AE, Godden AR, Yildirim N, Randawa A, Law R, Rusby JE. 

#CATP

RNASEH2B loss and PARP inhibition in advanced prostate cancer -  J Clin Invest. 2024 Jun 4:e178278. 

Carmichael J, Figueiredo I, Gurel B, Beije N, Yuan W, Rekowski J, Seed G, Carreira S, Bertan C, Fenor de la Maza MLD, Chandran K, Neeb A, Welti J, Gallagher L, Bogdan D, Crespo M, Riisnaes R, Ferreira A, Miranda S, Lu J, Shen MM, Hall E, Porta N, Westaby D, Guo C, Grochot R, Lord CJ, Mateo J, Sharp A, de Bono J.

#CATP #ClinInfra

Optical projection tomography implemented for accessibility and low cost (OPTImAL) - Philos Trans A Math Phys Eng Sci. 2024 Jul 9;382(2274):20230101.

Darling C, Kumar S, Alexandrov Y, de Faye J, Almagro Santiago J, Rýdlová A, Bugeon L, Dallman MJ, Behrens AJ, French PMW, McGinty J. 

#Affiliation

How Do Patients Use Self-Care to Manage Nonspecific Symptoms Prior to a Cancer Diagnosis? A Rapid Review to Inform Future Interventions to Reduce Delays in Presentation to Primary Care - European Journal of Cancer Care, vol. 2024, Article ID 5580195, 15 pages, 2024.

Georgia Wilson, Hannah R. Brewer, James M. Flanagan, Christian von Wagner, Yasemin Hirst. 

#ClinInfra

Pseudomembranous colitis and Parabacteroides distasonis bacteraemia: a rare clinical presentation - Clin J Gastroenterol. 2024 Jun;17(3):457-460.

Hsu C, Moore-Gillon C, Vithayathil M, Karim S. 

#CATP

Chemical tools for profiling the intracellular ADP-ribosylated proteome - RSC Chem Biol. 2024 May 22;5(7):640-651.

Draganov SD, Gruet MJ, Conole D, Balcells C, Siskos AP, Keun HC, Haskard DO, Tate EW.

#NonClinStud

A functional survey of the regulatory landscape of estrogen-receptor-positive breast cancer evolution - Cancer Discov. 2024 May 16.

Barozzi I, Slaven N, Canale E, Lopes R, Amorim Monteiro Barbosa I, Bleu M, Ivanoiu D, Pacini C, Mensa E, Chambers A, Bravaccini S, Ravaioli S, Gyorffy B, Dieci MV, Pruneri G, Galli GG, Magnani L. 

#OtherInfra

Clinical implications and molecular features of extracellular matrix networks in soft tissue sarcomas - Clin Cancer Res. 2024 May 29. 

Pankova V, Krasny L, Kerrison W, Tam YB, Chadha M, Burns J, Wilding CP, Chen L, Chowdhury A, Perkins E, Lee ATJ, Howell L, Guljar N, Sisley K, Fisher C, Chudasama P, Thway K, Jones RL, Huang PH.

#CATP

Secretome of Cancer-Associated Fibroblasts (CAFs) Influences Drug Sensitivity in Cancer Cells - J Proteome Res. 2024 May 20.

Lau R, Yu L, Roumeliotis TI, Stewart A, Pickard L, Choudhary JS, Banerji U. 

#ClinInfra

Robust prostate disease classification using transformers with discrete representations - Int J Comput Assist Radiol Surg. 2024 May 13. 

Santhirasekaram A, Winkler M, Rockall A, Glocker B. 

#CATP

Shining a spotlight on the inclusion of disabled participants in clinical trials: a mixed methods study - Trials. 2024 Apr 26;25(1):281.

Sakuma Y, Miller MLE, Babalis DS, Baker A, Reddi M, Anjum A, Bruton J, Jones KN, Mulla UZ, Taddese H. 

#ClinInfra

Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations - BioRxiv. April 20, 2024.

Angelos Vrynas, Sara Arfan, Karishma Satia, Salime Bazban-Shotorbani, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au

#DevFund #OtherInfra

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer - JCO Precis Oncol. 2024 Apr;8:e2300456.

Shaw JA, Page K, Wren E, de Bruin EC, Kalashnikova E, Hastings R, McEwen R, Zhang E, Wadsley M, Acheampong E, Renner D, Gleason KLT, Ambasager B, Stetson D, Fernandez-Garcia D, Guttery D, Allsopp RC, Rodriguez A, Zimmermann B, Sethi H, Aleshin A, Liu MC, Richards C, Stebbing J, Ali S, Rehman F, Cleator S, Kenny L, Ahmed S, Armstrong AC, Coombes RC. 

#ClinInfra

The Lancet Commission on prostate cancer: planning for the surge in cases - Lancet. 2024 Apr 4:S0140-6736(24)00651-2

James ND, Tannock I, N'Dow J, Feng F, Gillessen S, Ali SA, Trujillo B, Al-Lazikani B, Attard G, Bray F, Compérat E, Eeles R, Fatiregun O, Grist E, Halabi S, Haran Á, Herchenhorn D, Hofman M, Jalloh M, Loeb S, MacNair A, Mahal B, Mendes L, Moghul M, Moore C, Morgans A, Morris M, Murphy D, Murthy V, Nguyen PL, Padhani A, Parker C, Rush H, Sculpher M, Soule H, Sydes MR, Tilki D, Tunariu N, Villanti P, Xie LP. 

#CanTechCat

CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors - Clin Cancer Res. 2024 Apr 9:OF1-OF12.

Archer S, Brailey PM, Song M, Bartlett PD, Figueiredo I, Gurel B, Guo C, Brucklacher-Waldert V, Thompson HL, Akinwale J, Boyle SE, Rossant C, Birkett NR, Pizzey J, Maginn M, Legg J, Williams R, Johnston CM, Bland-Ward P, de Bono JS, Pierce AJ. 

#ClinInfra

Validated machine learning tools to distinguish immune checkpoint inhibitor, radiotherapy, COVID-19 and other infective pneumonitis - Radiother Oncol. 2024 Apr 4:195:110266.

Hindocha S, Hunter B, Linton-Reid K, George Charlton T, Chen M, Logan A, Ahmed M, Locke I, Sharma B, Doran S, Orton M, Bunce C, Power D, Ahmad S, Chan K, Ng P, Toshner R, Yasar B, Conibear J, Murphy R, Newsom-Davis T, Goodley P, Evison M, Yousaf N, Bitar G, McDonald F, Blackledge M, Aboagye E, Lee R. 

#CATP

Characterizing functional DNA damage and response caused by the combination of CHK1 and WEE1 inhibitors in ovarian and breast cancer models - BJC Rep 2, 27 (2024). 

Adam Stewart, Jiin Song, Lisa Pickard, Giovanna Muggiolu, Sylvie Sauvaigo, Alexis De Haven Brandon, Florence Raynaud & Udai Banerji

#ClinInfra

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells  - Cancer Discov. 2024 Mar 21:OF1-OF24. 

Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani

#OtherInfra #DevFund

Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30 - RSC Chem Biol, 2024, Advance Article.

Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W. Auner and  Edward W. Tate.

#DevFund

Genome-wide mapping of G-quadruplex DNA: a step-by-step guide to select the most effective method - RSC Chem Biol, 2024, Advance Article.

Silvia Galli, Gem Flint, Lucie Růžičková and Marco Di Antonio

#NonClinStud

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity - Nat Rev Cancer. 2024 Mar 7.

Pascal Meier, Arnaud J. Legrand, Dieter Adam & John Silke

#Affiliation

Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets - Nat Rev Cancer. 2024 Feb 29.

Edward W. Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang & Hening Lin 

#NonClinStud

Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer - Mol Cancer Ther. 2024 Feb 27.

Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M Jiménez-Vacas, Victor Gourain, Irene I Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Stefan Bräse, Nicole Jung, Simone Gräßle, Amanda Swain, Xavier Salvatella, Stephen R Plymate, Bissan Al-Lazikani, Henry W Long, Wei Yuan, Myles Brown, Andrew C B Cato, Johann S de Bono, Adam Sharp

#ClinInfra

A first-in-human phase I study of the PD-1 inhibitor, retifanlimab (INCMGA00012), in patients with advanced solid tumors (POD1UM-101) - ESMO Open. 2024 Feb 21;9(4):102254.

Lakhani N, Cosman R, Banerji U, Rasco D, Tomaszewska-Kiecana M, Garralda E, Kornacki D, Li J, Tian C, Bourayou N, Powderly J.

#ClinInfra

Circulating microRNA analysis in a prospective co-clinical trial identifies MIR652-3p as a response biomarker and driver of regorafenib resistance mechanisms in colorectal cancer - Clin Cancer Res. 2024 Feb 20.

Fiberbots: Robotic fibers for high-precision minimally invasive surgery - Sci Adv. 2024 Jan 19;10(3):eadj1984. 

Mohamed E.M.K. Abdelaziz, Jinshi Zhao, Bruno Gil Rosa, Hyun-Taek Lee, Daniel Simon, Khushi Vyas, Bing Li, Hanifa Koguna, Yue Li, Ali Anil Demircali, Huseyin Uvet, Gulsum Gencoglan, Arzu Akcay, Mohamed Elriedy, James Kinross, Ranan Dasgupta, Zoltan Takats, Eric Yeatman, Guang-Zhong Yang, Burak Temelkuran

#DevFund

Deep Learning for Delineation of the Spinal Canal in Whole-Body Diffusion-Weighted Imaging: Normalising Inter- and Intra-Patient Intensity Signal in Multi-Centre Datasets - Bioengineering (Basel). 2024 Jan 29;11(2):130.

Antonio Candito, Richard Holbrey, Ana Ribeiro, Christina Messiou, Nina Tunariu, Dow-Mu Koh, Matthew D Blackledge

#ClinInfra

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase - J Med Chem. 2024 Jan 25;67(2):1061-1078.

Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A. Andrei, Olivia Boyd, Naoko Masumoto, Ursula R. Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I. Raynaud, Rosemary Burke, Julian Blagg, Henry S. Rzepa, Christian Siebold, Anthony I. Magee, Thomas Lanyon-Hogg, and Edward W. Tate

#NonClinStud #DevFund

Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment - Int J Surg. 2024 Jan 22. 

Scarlet Nazarian, Ioannis Gkouzionis, Jamie Murphy, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

#NonClinStud

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation - Nat Biotechnol. 2024 Jan 8. 

Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Jack W. Houghton, Susana A. Palma-Duran, James I. MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S. Eggert & Edward W. Tate

#NonClinStud

Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2024 Jan 16;134(2):e175369. 

Magnus T Dillon, Jeane Guevara, Kabir Mohammed, Emmanuel C Patin, Simon A Smith, Emma Dean, Gemma N Jones, Sophie E Willis, Marcella Petrone, Carlos Silva, Khin Thway, Catey Bunce, Ioannis Roxanis, Pablo Nenclares, Anna Wilkins, Martin McLaughlin, Adoracion Jayme-Laiche, Sarah Benafif, Georgios Nintos, Vineet Kwatra, Lorna Grove, David Mansfield, Paula Proszek, Philip Martin, Luiza Moore, Karen E Swales, Udai Banerji, Mark P Saunders, James Spicer, Martin D Forster, Kevin J Harrington

#ClinInfra

Exposure to Aldehyde Cherry e-Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical Function - Environ Sci Technol. 2024 Jan 8.

Alexia Martin, Carmelo Tempra, Yuefan Yu, Juho Liekkinen, Roma Thakker, Hayoung Lee, Berta de Santos Moreno, Ilpo Vattulainen, Christos Rossios, Matti Javanainen, Jorge Bernardino de la Serna

#NonClinInfra

T-cell receptor determinants of response to chemoradiation in locally-advanced HPV16-driven malignancies - Front Oncol. 2024 Jan 3;13:1296948.

Nenclares P, Larkeryd A, Manodoro F, Lee JY, Lalondrelle S, Gilbert DC, Punta M, O'Leary B, Rullan A, Sadanandam A, Chain B, Melcher A, Harrington KJ, Bhide SA. 

#DataSciInfra

O-RADS MRI scoring system has the potential to reduce the frequency of avoidable adnexal surgery - Eur J Obstet Gynecol Reprod Biol. 2024 Jan 17:294:135-142. 

Yohann Dabi, Andrea Rockall, Léo Razakamanantsoa, Adalgisa Guerra, Laure S Fournier, Christina Fotopoulou, Cyril Touboul, Isabelle Thomassin-Naggara; Eurad Study Group

#ClinInfra

2023

Optimizing the FDA's Project Optimus: opportunities and challenges - Nat Rev Clin Oncol. 2023 Dec 21. 

Simon Rodney & Udai Banerji

#ClinInfra

 

Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study - Invest Radiol. 2023 Dec 1;58(12):823-831.

Rockall AG, Li X, Johnson N, Lavdas I, Santhakumaran S, Prevost AT, Punwani S, Goh V, Barwick TD, Bharwani N, Sandhu A, Sidhu H, Plumb A, Burn J, Fagan A, Wengert GJ, Koh DM, Reczko K, Dou Q, Warwick J, Liu X, Messiou C, Tunariu N, Boavida P, Soneji N, Johnston EW, Kelly-Morland C, De Paepe KN, Sokhi H, Wallitt K, Lakhani A, Russell J, Salib M, Vinnicombe S, Haq A, Aboagye EO, Taylor S, Glocker B. 

#ClinInfra

Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2023 Nov 7:e175369.

Dillon MT, Guevara J, Mohammed K, Patin EC, Smith SA, Dean E, Jones GN, Willis SE, Petrone M, Silva C, Thway K, Bunce C, Roxanis I, Nenclares P, Wilkins A, McLaughlin M, Jayme-Laiche A, Benafif S, Nintos G, Kwatra V, Grove L, Mansfield DC, Proszek P, Martin P, Moore L, Swales KE, Banerji U, Saunders MP, Spicer J, Forster MD, Harrington KJ. 

#ClinInfra

The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis - Front Bioeng Biotechnol. 2023 Nov 29:11:1305936.

Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases - Br J Radiol. 2023 Nov;96(1151):20230378.

Donners R, Candito A, Blackledge M, Rata M, Messiou C, Koh DM, Tunariu N. 

#ClinInfra

Group Spike and Slab Variational Bayes - Arxiv [Preprint]. 15 Nov 2023 

Michael Komodromos, Marina Evangelou, Sarah Filippi, Kolyan Ray

#NonClinStud

Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biorxiv.  November 23, 2023.

Melina Beykou, Vicky Bousgouni, Nicolas Moser, Pantelis Georgiou, Chris Bakal

#NonClinStud

Radiomics-based decision support tool assists radiologists in small lung nodule classification and improves lung cancer early diagnosis - Br J Cancer. 2023 Nov 6.

Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian McNamara, Toby Burn, Emily Guilhem, Marcos Mestas Nuñez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye & Anand Devaraj

#CATP

Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response - JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad077.

Parker C, Tunariu N, Tovey H, Alonzi R, Blackledge MD, Cook GJR, Chua S, Du Y, Hafeez S, Murray I, Padhani AR, Staffurth J, Tree A, Stidwill H, Finch J, Curcean A, Chatfield P, Perry S, Koh DM, Hall E. 

#ClinInfra

Relative fat fraction of malignant bone lesions from breast cancer, prostate cancer and myeloma are significantly lower than normal bone marrow and shows excellent interobserver agreement. - Br J Radiol. 2023 Oct 31:20230240.

Castagnoli F, Donners R, Tunariu N, Messiou C, Koh DM. 

#ClinInfra

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma - Cell Rep. 2023 Oct 31;42(10):113307.

Yuewei Xu, Sarah Spear, Yurui Ma, Marc P Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R Shepherd, Iain McNeish, Hector C Keun, Anke Nijhuis

#NonClinStud

Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance - Nature. 2023 Oct 16.

Christina Guo, Adam Sharp, Bora Gurel, Mateus Crespo, Ines Figueiredo, Suneil Jain, Ursula Vogl, Jan Rekowski, Mahtab Rouhifard, Lewis Gallagher, Wei Yuan, Suzanne Carreira, Khobe Chandran, Alec Paschalis, Ilaria Colombo, Anastasios Stathis, Claudia Bertan, George Seed, Jane Goodall, Florence Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Denisa Bogdan, Crescens Tiu, Reece Caldwell, Caterina Aversa, Ana Ferreira, Antje Neeb, Nina Tunariu, Daniel Westaby, Juliet Carmichael, Maria de los Dolores Fenor de la Maza, Christina Yap, Ruth Matthews, Hannah Badham, Toby Prout, Alison Turner, Mona Parmar, Holly Tovey, Ruth Riisnaes, Penny Flohr, Jesus Gil, David Waugh, Shaun Decordova, Anna Schlag, Bianca Calì, Andrea Alimonti & Johann S. de Bono

#ClinInfra

Ravindhi Murphy, Gurvin Chander, Maria Martinez, Caroline Ward, Sairah R. Khan, Mitesh Naik, Tara Barwick, Eric Aboagye, Rohini Sharma

#ClinInfra

The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development - BMC Med. 2023 Oct 4;21(1):383. 

Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B Hanna, Melody Zhifang Ni, Christopher J Peters

#CATP

Olaparib and celarasertib (AZD6738) in patients with triple negative advanced breast cancer: results from Cohort E of the plasmaMATCH trial (CRUK/15/010) - Clin Cancer Res. 2023 Sep 29.

Ring A, Kilburn LS, Pearson A, Moretti L, Afshari-Mehr A, Wardley AM, Gurel B, Macpherson IR, Riisnaes R, Baird RD, Martin S, Roylance R, Johnson H, Ferreira A, Winter MC, Dunne K, Copson E, Hickish T, Burcombe R, Randle K, Serra V, Llop-Guevara A, Bliss JM, Turner NC.

#ClinInfra

The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer - J Clin Invest. 2023 Sep 26:e169200.

Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L. 

#ClinInfra

Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma - Br J Cancer. 2023 Sep;129(5):811-818.

Lopez J, Lai-Kwon J, Molife R, Welsh L, Tunariu N, Roda D, Fernández-García P, Lladó V, McNicholl AG, Rosselló CA, Taylor RJ, Azaro A, Rodón J, Sludden J, Veal GJ, Plummer R, Urruticoechea A, Lahuerta A, Mujika K, Escribá PV. A.

#ClinInfra

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response - Nat Genet. 2023 Aug;55(8):1311-1323.

Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, …Rachael Natrajan

#CATP

Development and Validation of a New BAG-1L-Specific Antibody to Quantify BAG-1L Protein Expression in Advanced Prostate Cancer - Lab Invest. 2023 Aug 29;103(11):100245.

Neeb A, Figueiredo I, Gurel B, Nava Rodrigues D, Rekowski J, Riisnaes R, Ferreira A, Miranda S, Crespo M, Westaby D, de Los Dolores Fenor de La Maza M, Guo C, Carmichael J, Grochot R, Tunariu N, Cato ACB, Plymate SR, de Bono JS, Sharp A. 

#ClinInfra

The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases - Eur Radiol. 2023 Aug 24.

Donners R, Tunariu N, Tovey H, Hall E, Chua S, Cook G, Du Y, Blackledge MD, Parker CC, Koh DM. 

#ClinInfra

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells - Nat Cancer. 2023 Aug;4(8):1102-1121.

Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A. 

#ClinInfra

openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation - J Microsc. 2023 Aug 24.

Jonathan Lightley, Sunil Kumar, M Q Lim, E Garcia, F Görlitz, Y Alexandrov, T Parrado, C Hollick, E Steele, K Roßmann, J Graham, J Broichhagen, I A McNeish, C A Roufosse, M A A Neil, Chris Dunsby, P M W French

#CATP

Accelerating 4D image reconstruction magnetic resonance-guided radiotherapy - Phys Imaging Radiat Oncol. 2023 Aug 23.

Participatory evaluation of the process of co-producing resources for the public on data science and artificial intelligence - Res Involv Engagem. 2023 Aug 14;9(1):67.

Piotr Teodorowski, Kelly Gleason, Jonathan J. Gregory, Martha Martin, Reshma Punjabi, Suzanne Steer, Serdar Savasir, Pournamy Vema, Kabelo Murray, Helen Ward & Dorota Chapko 

#Affiliation #OtherInfra

The clinical terrain of immunotherapies in heterogeneous pancreatic cancer: unravelling challenges and opportunities - J Pathol. 2023 Aug 7.

Melanie Herpels, Jun Ishihara, Anguraj Sadanandam

#CATP

Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognostics - IEEE Sens Lett. 2023 Aug;7(8):1-4. 

Joseph Broomfield, Melpomeni Kalofonou, Sylvia Franklin, Sue M Powell, Thomas Pataillot-Meakin, Nicolas Moser, Charlotte L Bevan, Pantelis Georgiou

#NonClinStud

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target - Nat Metab. 2023 Aug;5(8):1303-1318. 

Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch & Owen J. Sansom

#NonClinStud

Role of procalcitonin in predicting complications of Kawasaki disease - Arch Dis Child. 2023 Jul 31;archdischild-2023-325787.

Kazuki Iio, Heather Hanna, Melina Beykou, Chris Gale, Jethro Adam Herberg

#NonClinStud

Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks - Comput Biol Med. 2023 Jul;161:107027. 

Prateek Tripathi, Costanza Gulli, Joseph Broomfield, George Alexandrou, Melpomeni Kalofonou, Charlotte Bevan, Nicolas Moser, Pantelis Georgiou

#NonClinStud

Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines - J Proteomics. 2023 Jul 20;104973. 

Rachel Lau, Lu Yu, Theodoros I Roumeliotis, Adam Stewart, Lisa Pickard, Ruth Riisanes, Bora Gurel, Johann S de Bono, Jyoti S Choudhary, Udai Banerji

#ClinInfra

Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomics - Cell Chem Biol. 2023 Jul 20;30(7):828-838.e4.

Matthew E.H. White, Jesus Gil, Edward W. Tate

#NonClinStud

Clinical trial designs for evaluating and exploiting cancer evolution - Cancer Treat Rev. 2023 Jul;118:102583.

Alvaro H Ingles Garces, Nuria Porta, Trevor A Graham, Udai Banerji

#ClinInfra

The potential role of the microbiota in prostate cancer pathogenesis and treatment. -  Nat Rev Urol. 2023 Jul 25.

Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, Liu L, Maraccani L, Guccini I, Migliorini D, de Bono J, Alimonti A. 

#ClinInfra

Critical role of antioxidant programs in enzalutamide-resistant prostate cancer - Oncogene. 2023 Jul;42(30):2347-2359.

Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV.

#ClinInfra

A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer - Br J Cancer. 2023 Jul;129(1):38-45.

Rebecca Kristeleit, Ruth Plummer, Robert Jones, Louise Carter, Sarah Blagden, Debashis Sarker, Tobias Arkenau, Thomas R Jeffry Evans, Sarah Danson, Stefan N Symeonides, Gareth J Veal, Barbara J Klencke, Mark M Kowalski, Udai Banerji

#ClinInfra

Circulating Tumor Cell Cluster Sorting by Size and Asymmetry - Methods Mol Biol. 2023;2679:15-23.

Sam H Au

#OtherInfra

Dynamics and Molecular Interactions of GPI-Anchored CD59 - Toxins 2023, 15(7), 430.

Tomas B. Voisin, Emma C. Couves, Edward W. Tate and Doryen Bubeck

#NonClinStud

Cancer Loyalty Card Study (CLOCS): feasibility outcomes for an observational case-control study focusing on the patient interval in ovarian cancer - BMJ Open. 2023 Jun 14;13(6):e066022.

Hannah R Brewer, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James Flanagan, Yasemin Hirst

#ClinInfra

Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma - Cancers (Basel). 2023 Jun 9;15(12):3131. 

Gitanjali Sharma, Marta C Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H Plate, Wojciech Kaspera, Gabriela Kramer-Marek

#NonClinStud

Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19 - Sci Rep. 2023 Jun 29;13(1):10568. 

Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. Aboagye, Richard W. Lee & Matthew D. Blackledge

#CATP

The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer - Br J Cancer. 2023 Jun;128(12):2326-2337.

Theodora A. Constantin, Anabel Varela-Carver, Kyle K. Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A. Leach, Chun-Fui Lai, Edward K. Ainscow, Ash K. Bahl, David Carling, Matthew J. Fuchter, Simak Ali & Charlotte L. Bevan

#ClinInfra

Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer? - Prostate Cancer Prostatic Dis. 2023 Jun;26(2):282-286.

Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed & Mathias Winkler

#CATP

Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study - MedRxiv

Hannah R. Brewer, Qianhui Jiang, Sudha Sundar, Yasemin Hirst, James M. Flanagan

#ClinInfra

Distributed large-scale graph processing on FPGAs - J Big Data. 2023;10(1):95.

Amin Sahebi, Marco Barbone, Marco Procaccini, Wayne Luk, Georgi Gaydadjiev, Roberto Giorgi

#NonClinStud #DevFund

Advanced MR Techniques for Preoperative Glioma Characterization: Part 1 & Part 2 - J Magn Reson Imaging. 2023 Jun;57(6):1676-1695

[...], Simran Kukran, [...]

#NonClinStud

Capillary-Scale Hydrogel Microchannel Networks by Wire Templating - Small 2023 Jun 2;e2301163.

Shusei Kawara, Brian Cunningham, James Bezer, Neelima Kc, Jingwen Zhu, Meng-Xing Tang, Jun Ishihara, James J Choi, Sam H Au

#NonClinStud #OtherInfra

A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery - Int J Comput Assist Radiol Surg. 2023 Jun 8.

Ioannis Gkouzionis, Yican Zhong, Scarlet Nazarian, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

#NonClinStud

Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study - PLoS One. 2023 May 24;18(5):e0285399.

Seema Dadhania, Lillie Pakzad-Shahabi, Sanjay Mistry, Matt Williams

#CATP

Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives - Cancer Imaging. 2023 May 31;23(1):53.

Lother D, Robert M, Elwood E, Smith S, Tunariu N, Johnston SRD, Parton M, Bhaludin B, Millard T, Downey K, Sharma B. 

#ClinInfra

Active mesh and neural network pipeline for cell aggregate segmentation - Biophys J. 2023 May 2;122(9):1586-1599.

Matthew B Smith, Hugh Sparks, Jorge Almagro, Agathe Chaigne, Axel Behrens, Chris Dunsby, Guillaume Salbreux

#Affiliation 

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer - Microbiome. 2023 May 8;11(1):100.

James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare & James Kinross

#NonClinStud

Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function - Int J Mol Sci. 2023 May 15;24(10):8806.

Mahmoud I Khalil, Heba M Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E Pardo

#OtherInfra

Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth - Cell Death Discov. 2023 May 19;9(1):172.

Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier E. Pardo, Philip Beesley, Nelofer Syed & Robin S. B. Williams

#OtherInfra

REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment - Lancet Oncol. 2023 May;24(5):e219-e227.

Ehsan Ghorani, Matteo Quartagno, Fiona Blackhall, Duncan C Gilbert, Mary O'Brien, Christian Ottensmeier, Elena Pizzo, James Spicer, Alex Williams, Philip Badman, Mahesh K B Parmar, Michael J Seckl; REFINE-Lung Investigators

#ClinInfra

Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer - Eur Urol Open Sci. 2023 May 2;52:72-78. doi: 10.1016/j.euros.2023.04.003. 

Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb, Bora Gurel, Maria de Los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Daniel Westaby, Joaquin Mateo, Adam Sharp, Terri P McVeigh, Johann De Bono

#CATP #ClinInfra

A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation - BioRxiv 2023.04.18.537386.

Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Susana A. Palma-Duran, James I. MacRae, Goran Tomic, Lotte Carr, Julian Downward, Ulrike S. Eggert,  Edward W. Tate

#NonClinStud

A Transgender Patient with Prostate Cancer: Lessons Learnt - Eur Urol. 2023 Apr;83(4):379-380. 

Khobe Chandran, Rafael Grochot, Maria de Los Dolores Fenor De La Maza, Wei Yuan, Bora Gurel, Susana Miranda, Alec Paschalis, Ruth Riisnaes, Ines Figueiredo, Denisa Bogdan, Adam Sharp, Suzanne Carreira, Johann S de Bono

#ClinInfra

Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature. 2023 Apr;616(7957):563-573.

Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A. Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T. C. Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R. M. Black, Thomas B. K. Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M. Frankell, Maise Al Bakir, Emilia L. Lim, Mark S. Hill, Gareth A. Wilson, Daniel E. Cook, Nicolai J. Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, TRACERx Consortium, CAPTURE Consortium, Crispin T. Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward & George Kassiotis

#Affiliation

Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma - Hepatol Int. 2023 Apr 1.

Mathew Vithayathil, Antonio D’Alessio, Claudia Angela Maria Fulgenzi, Naoshi Nishida, Martin Schönlein, Johann von Felden, Kornelius Schulze, Henning Wege, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Valentina Zanuso, Tiziana Pressiani, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato & Rohini Sharma

#ClinInfra

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - Sci Rep. 2023 Apr 28;13(1):6963.

William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse

#NonClinStud

Acceleration-Based Kalman Tracking for Super-Resolution Ultrasound Imaging in vivo - Arxiv

Biao Huang, Jipeng Yan, Megan Morris, Victoria Sinnett, Navita Somaiah, Meng-Xing Tang

#NonClinStud

What is so Special About Digital Health in Cancer? - Clin Oncol (R Coll Radiol). 2023 Mar;35(3):147-149.

S Dadhania, M Williams

#CATP

Progression patterns and therapeutic sequencing following immune checkpoint inhibition for hepatocellular carcinoma: An international observational study - Liver Int. 2023 Mar;43(3):695-707

B7-H3 as a Therapeutic Target in Advanced Prostate Cancer - Eur Urol. 2023 Mar;83(3):224-238.

Christina Guo, Ines Figueiredo, Bora Gurel, Antje Neeb, George Seed, Mateus Crespo, Suzanne Carreira, Jan Rekowski, Lorenzo Buroni, Jon Welti, Denisa Bogdan, Lewis Gallagher, Adam Sharp, Maria D Fenor de la Maza, Pasquale Rescigno, Daniel Westaby, Khobe Chandran, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Bianca Calì, Andrea Alimonti, Silvia Bressan, Alana H T Nguyen, Michael M Shen, Jessica E Hawley, Aleksandar Obradovic, Charles G Drake, Claudia Bertan, Chloe Baker, Nina Tunariu, Wei Yuan, Johann S de Bono

#ClinInfra

Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting - Adv Mater. 2023 Mar 11;e2300413.

Adam Creamer, Alessandra Lo Fiego, Alice Agliano, Lino Prados-Martin, Håkon Høgset, Adrian Najer, Daniel A. Richards, Jonathan P. Wojciechowski, James E. J. Foote, Nayoung Kim, Amy Monahan, Jiaqing Tang, André Shamsabadi, Léa N. C. Rochet, Ioanna A. Thanasi, Laura R. de la Ballina, Charlotte L. Rapley, Stephen Turnock, Elizabeth A. Love, Laurence Bugeon, Margaret J. Dallman, Martin Heeney, Gabriela Kramer-Marek, Vijay Chudasama, Federico Fenaroli, Molly M. Stevens

#DevFund

Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer. - Cancer Cell. 2023 Mar 13;41(3):602-619.e11.

Bancaro N, Calì B, Troiani M, Elia AR, Arzola RA, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D'Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Di Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Pereira Mestre R, Bolis M, Gillessen Sommer S, de Bono J, Calcinotto A, Alimonti A. 

#ClinInfra

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth - Oncogene. 2023 Mar;42(12):926-937. 

Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann & Jennifer Munkley,

#CATP #ClinInfra

PETAL protocol: a phase Ib study of pembrolizumab after transarterial chemoembolization in hepatocellular carcinoma - Future Oncol. 2023 Mar;19(7):499-507. doi: 10.2217/fon-2022-0916. 

Petros Fessas, Bernhard Scheiner, Antonio D'Alessio, Claudia A M Fulgenzi, James Korolewicz, Caroline Ward, Paul Tait, Robert Thomas, Alessio Cortellini, Rohini Sharma, David J Pinato

#ClinInfra

Apoptosis-modulatory miR-361-3p as a novel treatment target in endocrine-responsive and endocrine-resistant breast cancer - J Endocrinol. 2023 Feb 11;256(3):e220229.

J N Zamarbide Losada, E Sulpice, S Combe, G S Almeida, D A Leach, J Choo, L Protopapa, M P Hamilton, S McGuire, X Gidrol, C L Bevan, C E Fletcher

#OtherInfra

Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste T. Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber

#OtherInfra

Association Between Purchase of Over-the-Counter Medications and Ovarian Cancer Diagnosis in the Cancer Loyalty Card Study (CLOCS): Observational Case-Control Study - JMIR Public Health Surveill. 2023 Jan 26;9:e41762. 

Hannah R Brewer, Yasemin Hirst, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James M Flanagan

#ClinInfra

Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer - Gene. 2023 Jan 20;850:146930. 

Uttom Kumar, Marcos Castellanos-Uribe, Sean T May, Ernesto Yagüe

#OtherInfra

H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways - Reprod Biol Endocrinol. 2023 Jan 26;21(1):9.

María Cristina Carbajo-García, Elena Juarez-Barber, Marina Segura-Benítez, Amparo Faus, Alexandra Trelis, Javier Monleón, Greta Carmona-Antoñanzas, Antonio Pellicer, James M Flanagan, Hortensia Ferrero

#ClinInfra

A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res. 2023 Jan 17;29(2):331-340.

Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji

#ClinInfra