This page contains the list of publications which have been supported by the CRUK Convergence Science Centre (incl. non-clinical and clinical studentships programmes) as well as by the previous Imperial and ICR CRUK centres (now part of the Convergence Science Centre)

 

 

2024

Shining a spotlight on the inclusion of disabled participants in clinical trials: a mixed methods study - Trials. 2024 Apr 26;25(1):281.

Sakuma Y, Miller MLE, Babalis DS, Baker A, Reddi M, Anjum A, Bruton J, Jones KN, Mulla UZ, Taddese H. 

 

Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations - BioRxiv. April 20, 2024.

Angelos Vrynas, Sara Arfan, Karishma Satia, Salime Bazban-Shotorbani, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au

 

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer - JCO Precis Oncol. 2024 Apr;8:e2300456.

Shaw JA, Page K, Wren E, de Bruin EC, Kalashnikova E, Hastings R, McEwen R, Zhang E, Wadsley M, Acheampong E, Renner D, Gleason KLT, Ambasager B, Stetson D, Fernandez-Garcia D, Guttery D, Allsopp RC, Rodriguez A, Zimmermann B, Sethi H, Aleshin A, Liu MC, Richards C, Stebbing J, Ali S, Rehman F, Cleator S, Kenny L, Ahmed S, Armstrong AC, Coombes RC. 

 

The Lancet Commission on prostate cancer: planning for the surge in casesLancet. 2024 Apr 4:S0140-6736(24)00651-2

James ND, Tannock I, N'Dow J, Feng F, Gillessen S, Ali SA, Trujillo B, Al-Lazikani B, Attard G, Bray F, Compérat E, Eeles R, Fatiregun O, Grist E, Halabi S, Haran Á, Herchenhorn D, Hofman M, Jalloh M, Loeb S, MacNair A, Mahal B, Mendes L, Moghul M, Moore C, Morgans A, Morris M, Murphy D, Murthy V, Nguyen PL, Padhani A, Parker C, Rush H, Sculpher M, Soule H, Sydes MR, Tilki D, Tunariu N, Villanti P, Xie LP. 

 

CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive TumorsClin Cancer Res. 2024 Apr 9:OF1-OF12.

Archer S, Brailey PM, Song M, Bartlett PD, Figueiredo I, Gurel B, Guo C, Brucklacher-Waldert V, Thompson HL, Akinwale J, Boyle SE, Rossant C, Birkett NR, Pizzey J, Maginn M, Legg J, Williams R, Johnston CM, Bland-Ward P, de Bono JS, Pierce AJ. 

 

Validated machine learning tools to distinguish immune checkpoint inhibitor, radiotherapy, COVID-19 and other infective pneumonitisRadiother Oncol. 2024 Apr 4:195:110266.

Hindocha S, Hunter B, Linton-Reid K, George Charlton T, Chen M, Logan A, Ahmed M, Locke I, Sharma B, Doran S, Orton M, Bunce C, Power D, Ahmad S, Chan K, Ng P, Toshner R, Yasar B, Conibear J, Murphy R, Newsom-Davis T, Goodley P, Evison M, Yousaf N, Bitar G, McDonald F, Blackledge M, Aboagye E, Lee R

 

Characterizing functional DNA damage and response caused by the combination of CHK1 and WEE1 inhibitors in ovarian and breast cancer modelsBJC Rep 2, 27 (2024). 

Adam Stewart, Jiin Song, Lisa Pickard, Giovanna Muggiolu, Sylvie Sauvaigo, Alexis De Haven Brandon, Florence Raynaud & Udai Banerji

 

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells  - Cancer Discov. 2024 Mar 21:OF1-OF24. 

Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani

 

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions - BioRxiv preprint.

Z. Cheng, D.P. Ennis, B. Lu, H.B. Mirza, C. Sokota, B. Kaur, N. Singh*, O. Le Saux, G. Russo, G. Giannone, L.A. Tookman, J. Krell, C. Barnes, J. McDermott, I.A. McNeish

 

Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30 - RSC Chem Biol, 2024, Advance Article.

Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W. Auner and  Edward W. Tate.

 

Genome-wide mapping of G-quadruplex DNA: a step-by-step guide to select the most effective methodRSC Chem Biol, 2024, Advance Article.

Silvia Galli, Gem Flint, Lucie Růžičková and Marco Di Antonio

 

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunityNat Rev Cancer. 2024 Mar 7.

Pascal Meier, Arnaud J. Legrand, Dieter Adam & John Silke

 

Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets - Nat Rev Cancer. 2024 Feb 29.

Edward W. Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang & Hening Lin 

 

Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancerMol Cancer Ther2024 Feb 27.

Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M Jiménez-Vacas, Victor Gourain, Irene I Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Stefan Bräse, Nicole Jung, Simone Gräßle, Amanda Swain, Xavier Salvatella, Stephen R Plymate, Bissan Al-Lazikani, Henry W Long, Wei Yuan, Myles Brown, Andrew C B Cato, Johann S de Bono, Adam Sharp

 

A first-in-human phase I study of the PD-1 inhibitor, retifanlimab (INCMGA00012), in patients with advanced solid tumors (POD1UM-101) - ESMO Open. 2024 Feb 21;9(4):102254.

Lakhani N, Cosman R, Banerji U, Rasco D, Tomaszewska-Kiecana M, Garralda E, Kornacki D, Li J, Tian C, Bourayou N, Powderly J.

 

Circulating microRNA analysis in a prospective co-clinical trial identifies MIR652-3p as a response biomarker and driver of regorafenib resistance mechanisms in colorectal cancerClin Cancer Res. 2024 Feb 20.

Somaieh Hedayat, Luciano Cascione, David Cunningham, Marta Schirripa, Andrea Lampis, Jens C Hahne, Nina Tunariu, Sung Pil Hong, Silvia Marchetti, Khurum Khan, Elisa Fontana, Valentina Angerilli, Mia Delrieux, Daniel Nava Rodrigues, Letizia Procaccio, Sheela Rao, David Watkins, Naureen Starling, Ian Chau, Chiara Braconi, Nicos Fotiadis, Ruwaida Begum, Naomi Guppy, Louise Howell, Melanie Valenti, Scott Cribbes, Bernadett Kolozsvari, Vladimir Kirkin, Sara Lonardi, Michele Ghidini, Rodolfo Passalacqua, Raghad Elghadi, Luca Magnani, David J Pinato, Federica Di Maggio, Filippo Ghelardi, Elisa Sottotetti, Guglielmo Vetere, Paolo Ciraci, Georgios Vlachogiannis, Filippo Pietrantonio, Chiara Cremolini, Alessio Cortellini, Fotios Loupakis, Matteo Fassan, Nicola Valeri

 

Fiberbots: Robotic fibers for high-precision minimally invasive surgery - Sci Adv. 2024 Jan 19;10(3):eadj1984. 

Mohamed E.M.K. Abdelaziz, Jinshi Zhao, Bruno Gil Rosa, Hyun-Taek Lee, Daniel Simon, Khushi Vyas, Bing Li, Hanifa Koguna, Yue Li, Ali Anil Demircali, Huseyin Uvet, Gulsum Gencoglan, Arzu Akcay, Mohamed Elriedy, James Kinross, Ranan Dasgupta, Zoltan Takats, Eric Yeatman, Guang-Zhong Yang, Burak Temelkuran

 

Deep Learning for Delineation of the Spinal Canal in Whole-Body Diffusion-Weighted Imaging: Normalising Inter- and Intra-Patient Intensity Signal in Multi-Centre DatasetsBioengineering (Basel). 2024 Jan 29;11(2):130.

Antonio Candito, Richard Holbrey, Ana Ribeiro, Christina Messiou, Nina Tunariu, Dow-Mu Koh, Matthew D Blackledge

 

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog AcyltransferaseJ Med Chem. 2024 Jan 25;67(2):1061-1078.

Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A. Andrei, Olivia Boyd, Naoko Masumoto, Ursula R. Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I. Raynaud, Rosemary Burke, Julian Blagg, Henry S. Rzepa, Christian Siebold, Anthony I. Magee, Thomas Lanyon-Hogg, and Edward W. Tate

 

Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessmentInt J Surg. 2024 Jan 22. 

Scarlet Nazarian, Ioannis Gkouzionis, Jamie Murphy, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

 

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylationNat Biotechnol. 2024 Jan 8. 

Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Jack W. Houghton, Susana A. Palma-Duran, James I. MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S. Eggert & Edward W. Tate

 

Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammationJ Clin Invest. 2024 Jan 16;134(2):e175369. 

Magnus T Dillon, Jeane Guevara, Kabir Mohammed, Emmanuel C Patin, Simon A Smith, Emma Dean, Gemma N Jones, Sophie E Willis, Marcella Petrone, Carlos Silva, Khin Thway, Catey Bunce, Ioannis Roxanis, Pablo Nenclares, Anna Wilkins, Martin McLaughlin, Adoracion Jayme-Laiche, Sarah Benafif, Georgios Nintos, Vineet Kwatra, Lorna Grove, David Mansfield, Paula Proszek, Philip Martin, Luiza Moore, Karen E Swales, Udai Banerji, Mark P Saunders, James Spicer, Martin D Forster, Kevin J Harrington

 

Exposure to Aldehyde Cherry e-Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical FunctionEnviron Sci Technol. 2024 Jan 8.

Alexia Martin, Carmelo Tempra, Yuefan Yu, Juho Liekkinen, Roma Thakker, Hayoung Lee, Berta de Santos Moreno, Ilpo Vattulainen, Christos Rossios, Matti Javanainen, Jorge Bernardino de la Serna

 

O-RADS MRI scoring system has the potential to reduce the frequency of avoidable adnexal surgeryEur J Obstet Gynecol Reprod Biol. 2024 Jan 17:294:135-142. 

Yohann Dabi, Andrea Rockall, Léo Razakamanantsoa, Adalgisa Guerra, Laure S Fournier, Christina Fotopoulou, Cyril Touboul, Isabelle Thomassin-Naggara; Eurad Study Group

 

 

2023

Optimizing the FDA's Project Optimus: opportunities and challengesNat Rev Clin Oncol. 2023 Dec 21. 

Simon Rodney & Udai Banerji

 

Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study - Invest Radiol. 2023 Dec 1;58(12):823-831.

Rockall AG, Li X, Johnson N, Lavdas I, Santhakumaran S, Prevost AT, Punwani S, Goh V, Barwick TD, Bharwani N, Sandhu A, Sidhu H, Plumb A, Burn J, Fagan A, Wengert GJ, Koh DM, Reczko K, Dou Q, Warwick J, Liu X, Messiou C, Tunariu N, Boavida P, Soneji N, Johnston EW, Kelly-Morland C, De Paepe KN, Sokhi H, Wallitt K, Lakhani A, Russell J, Salib M, Vinnicombe S, Haq A, Aboagye EO, Taylor S, Glocker B. 

 

Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2023 Nov 7:e175369.

Dillon MT, Guevara J, Mohammed K, Patin EC, Smith SA, Dean E, Jones GN, Willis SE, Petrone M, Silva C, Thway K, Bunce C, Roxanis I, Nenclares P, Wilkins A, McLaughlin M, Jayme-Laiche A, Benafif S, Nintos G, Kwatra V, Grove L, Mansfield DC, Proszek P, Martin P, Moore L, Swales KE, Banerji U, Saunders MP, Spicer J, Forster MD, Harrington KJ. 

 

The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesisFront Bioeng Biotechnol. 2023 Nov 29:11:1305936.

Stylianos Kechagias, Konstantinos Theodoridis, Joseph Broomfield, Kenny Malpartida-Cardenas, Ruth Reid, Pantelis Georgiou, Richard J van Arkel, Jonathan R T Jeffers

 

Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases - Br J Radiol. 2023 Nov;96(1151):20230378.

Donners R, Candito A, Blackledge M, Rata M, Messiou C, Koh DM, Tunariu N

 

Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biorxiv.  November 23, 2023.

Melina Beykou, Vicky Bousgouni, Nicolas Moser, Pantelis GeorgiouChris Bakal

 

Radiomics-based decision support tool assists radiologists in small lung nodule classification and improves lung cancer early diagnosisBr J Cancer. 2023 Nov 6.

Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian McNamara, Toby Burn, Emily Guilhem, Marcos Mestas Nuñez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye & Anand Devaraj

 

Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad077.

Parker C, Tunariu N, Tovey H, Alonzi R, Blackledge MD, Cook GJR, Chua S, Du Y, Hafeez S, Murray I, Padhani AR, Staffurth J, Tree A, Stidwill H, Finch J, Curcean A, Chatfield P, Perry S, Koh DM, Hall E. 

 

Relative fat fraction of malignant bone lesions from breast cancer, prostate cancer and myeloma are significantly lower than normal bone marrow and shows excellent interobserver agreement. - Br J Radiol. 2023 Oct 31:20230240.

Castagnoli F, Donners R, Tunariu N, Messiou C, Koh DM. 

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinomaCell Rep. 2023 Oct 31;42(10):113307.

Yuewei Xu, Sarah Spear, Yurui Ma, Marc P Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R Shepherd, Iain McNeish, Hector C Keun, Anke Nijhuis

 

Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance - Nature. 2023 Oct 16.

Christina Guo, Adam Sharp, Bora Gurel, Mateus Crespo, Ines Figueiredo, Suneil Jain, Ursula Vogl, Jan Rekowski, Mahtab Rouhifard, Lewis Gallagher, Wei Yuan, Suzanne Carreira, Khobe Chandran, Alec Paschalis, Ilaria Colombo, Anastasios Stathis, Claudia Bertan, George Seed, Jane Goodall, Florence Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Denisa Bogdan, Crescens Tiu, Reece Caldwell, Caterina Aversa, Ana Ferreira, Antje Neeb, Nina Tunariu, Daniel Westaby, Juliet Carmichael, Maria de los Dolores Fenor de la Maza, Christina Yap, Ruth Matthews, Hannah Badham, Toby Prout, Alison Turner, Mona Parmar, Holly Tovey, Ruth Riisnaes, Penny Flohr, Jesus Gil, David Waugh, Shaun Decordova, Anna Schlag, Bianca Calì, Andrea Alimonti & Johann S. de Bono

 

Ravindhi Murphy, Gurvin Chander, Maria Martinez, Caroline Ward, Sairah R. Khan, Mitesh Naik, Tara Barwick, Eric Aboagye, Rohini Sharma

 

The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide developmentBMC Med. 2023 Oct 4;21(1):383. 

Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B Hanna, Melody Zhifang Ni, Christopher J Peters

 

Olaparib and celarasertib (AZD6738) in patients with triple negative advanced breast cancer: results from Cohort E of the plasmaMATCH trial (CRUK/15/010) - Clin Cancer Res. 2023 Sep 29.

Ring A, Kilburn LS, Pearson A, Moretti L, Afshari-Mehr A, Wardley AM, Gurel B, Macpherson IR, Riisnaes R, Baird RD, Martin S, Roylance R, Johnson H, Ferreira A, Winter MC, Dunne K, Copson E, Hickish T, Burcombe R, Randle K, Serra V, Llop-Guevara A, Bliss JM, Turner NC.

 

The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer - J Clin Invest. 2023 Sep 26:e169200.

Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L. 

 

Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma - Br J Cancer. 2023 Sep;129(5):811-818.

Lopez J, Lai-Kwon J, Molife R, Welsh L, Tunariu N, Roda D, Fernández-García P, Lladó V, McNicholl AG, Rosselló CA, Taylor RJ, Azaro A, Rodón J, Sludden J, Veal GJ, Plummer R, Urruticoechea A, Lahuerta A, Mujika K, Escribá PV. A.

 

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress responseNat Genet. 2023 Aug;55(8):1311-1323.

Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, …Rachael Natrajan

 

Development and Validation of a New BAG-1L-Specific Antibody to Quantify BAG-1L Protein Expression in Advanced Prostate Cancer - Lab Invest. 2023 Aug 29;103(11):100245.

Neeb A, Figueiredo I, Gurel B, Nava Rodrigues D, Rekowski J, Riisnaes R, Ferreira A, Miranda S, Crespo M, Westaby D, de Los Dolores Fenor de La Maza M, Guo C, Carmichael J, Grochot R, Tunariu N, Cato ACB, Plymate SR, de Bono JS, Sharp A. 

 

The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases - Eur Radiol. 2023 Aug 24.

Donners R, Tunariu N, Tovey H, Hall E, Chua S, Cook G, Du Y, Blackledge MD, Parker CC, Koh DM. 

 

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells - Nat Cancer. 2023 Aug;4(8):1102-1121.

Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A. 

 

openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operationJ Microsc. 2023 Aug 24.

Jonathan Lightley, Sunil Kumar, M Q Lim, E Garcia, F Görlitz, Y Alexandrov, T Parrado, C Hollick, E Steele, K Roßmann, J Graham, J Broichhagen, I A McNeish, C A Roufosse, M A A Neil, Chris Dunsby, P M W French

 

Accelerating 4D image reconstruction magnetic resonance-guided radiotherapyPhys Imaging Radiat Oncol. 2023 Aug 23.

Bastien Lecoeur, Marco Barbone, Jessica Gough, Uwe Oelfke, Wayne Luk, Georgi Gaydadjiev, Andreas Wetscherek

 

Participatory evaluation of the process of co-producing resources for the public on data science and artificial intelligenceRes Involv Engagem. 2023 Aug 14;9(1):67.

Piotr Teodorowski, Kelly Gleason, Jonathan J. Gregory, Martha Martin, Reshma Punjabi, Suzanne Steer, Serdar Savasir, Pournamy Vema, Kabelo Murray, Helen Ward & Dorota Chapko 

 

The clinical terrain of immunotherapies in heterogeneous pancreatic cancer: unravelling challenges and opportunitiesJ Pathol. 2023 Aug 7.

Melanie Herpels, Jun Ishihara, Anguraj Sadanandam

 

Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognosticsIEEE Sens Lett. 2023 Aug;7(8):1-4. 

Joseph Broomfield, Melpomeni Kalofonou, Sylvia Franklin, Sue M Powell, Thomas Pataillot-Meakin, Nicolas Moser, Charlotte L Bevan, Pantelis Georgiou

 

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target - Nat Metab. 2023 Aug;5(8):1303-1318. 

Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch & Owen J. Sansom

 

Role of procalcitonin in predicting complications of Kawasaki diseaseArch Dis Child. 2023 Jul 31;archdischild-2023-325787.

Kazuki Iio, Heather Hanna, Melina Beykou, Chris Gale, Jethro Adam Herberg

 

Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks - Comput Biol Med. 2023 Jul;161:107027. 

Prateek Tripathi, Costanza Gulli, Joseph Broomfield, George Alexandrou, Melpomeni Kalofonou, Charlotte Bevan, Nicolas Moser, Pantelis Georgiou

 

Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell linesJ Proteomics. 2023 Jul 20;104973. 

Rachel Lau, Lu Yu, Theodoros I Roumeliotis, Adam Stewart, Lisa Pickard, Ruth Riisanes, Bora Gurel, Johann S de Bono, Jyoti S Choudhary, Udai Banerji

 

Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomicsCell Chem Biol. 2023 Jul 20;30(7):828-838.e4.

Matthew E.H. White, Jesus Gil, Edward W. Tate

 

Clinical trial designs for evaluating and exploiting cancer evolution - Cancer Treat Rev. 2023 Jul;118:102583.

Alvaro H Ingles Garces, Nuria Porta, Trevor A Graham, Udai Banerji

 

The potential role of the microbiota in prostate cancer pathogenesis and treatment. -  Nat Rev Urol. 2023 Jul 25.

Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, Liu L, Maraccani L, Guccini I, Migliorini D, de Bono J, Alimonti A. 

 

Critical role of antioxidant programs in enzalutamide-resistant prostate cancer - Oncogene. 2023 Jul;42(30):2347-2359.

Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV.

 

A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer - Br J Cancer. 2023 Jul;129(1):38-45.

Rebecca Kristeleit, Ruth Plummer, Robert Jones, Louise Carter, Sarah Blagden, Debashis Sarker, Tobias Arkenau, Thomas R Jeffry Evans, Sarah Danson, Stefan N Symeonides, Gareth J Veal, Barbara J Klencke, Mark M Kowalski, Udai Banerji

 

Circulating Tumor Cell Cluster Sorting by Size and Asymmetry - Methods Mol Biol. 2023;2679:15-23.

Sam H Au

 

Dynamics and Molecular Interactions of GPI-Anchored CD59Toxins 2023, 15(7), 430.

Tomas B. Voisin, Emma C. Couves, Edward W. Tate and Doryen Bubeck

 

Cancer Loyalty Card Study (CLOCS): feasibility outcomes for an observational case-control study focusing on the patient interval in ovarian cancer - BMJ Open. 2023 Jun 14;13(6):e066022.

Hannah R Brewer, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James Flanagan, Yasemin Hirst

 

Immuno-PET Imaging of Tumour PD-L1 Expression in GlioblastomaCancers (Basel). 2023 Jun 9;15(12):3131. 

Gitanjali Sharma, Marta C Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H Plate, Wojciech Kaspera, Gabriela Kramer-Marek

 

Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19Sci Rep. 2023 Jun 29;13(1):10568. 

Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. Aboagye, Richard W. Lee & Matthew D. Blackledge

 

The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer - Br J Cancer. 2023 Jun;128(12):2326-2337.

Theodora A. Constantin, Anabel Varela-Carver, Kyle K. Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A. Leach, Chun-Fui Lai, Edward K. Ainscow, Ash K. Bahl, David Carling, Matthew J. Fuchter, Simak Ali & Charlotte L. Bevan

 

Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer?Prostate Cancer Prostatic Dis. 2023 Jun;26(2):282-286.

Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed & Mathias Winkler

 

Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study - MedRxiv

Hannah R. Brewer, Qianhui Jiang, Sudha Sundar, Yasemin Hirst, James M. Flanagan

 

Distributed large-scale graph processing on FPGAsJ Big Data. 2023;10(1):95.

Amin Sahebi, Marco Barbone, Marco Procaccini, Wayne Luk, Georgi Gaydadjiev, Roberto Giorgi

 

Advanced MR Techniques for Preoperative Glioma Characterization: Part 1 & Part 2 - J Magn Reson Imaging. 2023 Jun;57(6):1676-1695

[...], Simran Kukran, [...]

 

Capillary-Scale Hydrogel Microchannel Networks by Wire Templating - Small 2023 Jun 2;e2301163.

Shusei Kawara, Brian Cunningham, James Bezer, Neelima Kc, Jingwen Zhu, Meng-Xing Tang, Jun Ishihara, James J Choi, Sam H Au

 

A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery - Int J Comput Assist Radiol Surg. 2023 Jun 8.

Ioannis Gkouzionis, Yican Zhong, Scarlet Nazarian, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

 

Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study - PLoS One. 2023 May 24;18(5):e0285399.

Seema Dadhania, Lillie Pakzad-Shahabi, Sanjay Mistry, Matt Williams

 

Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives - Cancer Imaging. 2023 May 31;23(1):53.

Lother D, Robert M, Elwood E, Smith S, Tunariu N, Johnston SRD, Parton M, Bhaludin B, Millard T, Downey K, Sharma B. 

 

Active mesh and neural network pipeline for cell aggregate segmentationBiophys J. 2023 May 2;122(9):1586-1599.

Matthew B Smith, Hugh Sparks, Jorge Almagro, Agathe Chaigne, Axel Behrens, Chris Dunsby, Guillaume Salbreux 

 

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancerMicrobiome. 2023 May 8;11(1):100.

James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare & James Kinross

 

Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival FunctionInt J Mol Sci. 2023 May 15;24(10):8806.

Mahmoud I Khalil, Heba M Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E Pardo

 

Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth - Cell Death Discov. 2023 May 19;9(1):172.

Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier E. Pardo, Philip Beesley, Nelofer Syed & Robin S. B. Williams

 

REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatmentLancet Oncol. 2023 May;24(5):e219-e227.

Ehsan Ghorani, Matteo Quartagno, Fiona Blackhall, Duncan C Gilbert, Mary O'Brien, Christian Ottensmeier, Elena Pizzo, James Spicer, Alex Williams, Philip Badman, Mahesh K B Parmar, Michael J Seckl; REFINE-Lung Investigators

 

Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer Eur Urol Open Sci. 2023 May 2;52:72-78. doi: 10.1016/j.euros.2023.04.003. 

Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb, Bora Gurel, Maria de Los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Daniel Westaby, Joaquin Mateo, Adam Sharp, Terri P McVeigh, Johann De Bono

 

A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation - BioRxiv 2023.04.18.537386.

Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Susana A. Palma-Duran, James I. MacRae, Goran Tomic, Lotte Carr, Julian Downward, Ulrike S. Eggert,  Edward W. Tate

 

A Transgender Patient with Prostate Cancer: Lessons Learnt - Eur Urol. 2023 Apr;83(4):379-380. 

Khobe Chandran, Rafael Grochot, Maria de Los Dolores Fenor De La Maza, Wei YuanBora Gurel, Susana Miranda, Alec Paschalis, Ruth Riisnaes, Ines Figueiredo, Denisa Bogdan, Adam Sharp, Suzanne Carreira, Johann S de Bono

 

Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature. 2023 Apr;616(7957):563-573.

Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A. Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T. C. Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R. M. Black, Thomas B. K. Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M. Frankell, Maise Al Bakir, Emilia L. Lim, Mark S. Hill, Gareth A. Wilson, Daniel E. Cook, Nicolai J. Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, TRACERx Consortium, CAPTURE Consortium, Crispin T. Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward & George Kassiotis

 

Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma - Hepatol Int. 2023 Apr 1.

Mathew Vithayathil, Antonio D’Alessio, Claudia Angela Maria Fulgenzi, Naoshi Nishida, Martin Schönlein, Johann von Felden, Kornelius Schulze, Henning Wege, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Valentina Zanuso, Tiziana Pressiani, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato & Rohini Sharma

 

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - Sci Rep. 2023 Apr 28;13(1):6963.

William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse

 

Acceleration-Based Kalman Tracking for Super-Resolution Ultrasound Imaging in vivo - Arxiv

Biao Huang, Jipeng Yan, Megan Morris, Victoria Sinnett, Navita SomaiahMeng-Xing Tang

 

What is so Special About Digital Health in Cancer? - Clin Oncol (R Coll Radiol). 2023 Mar;35(3):147-149.

S DadhaniaM Williams

 

Progression patterns and therapeutic sequencing following immune checkpoint inhibition for hepatocellular carcinoma: An international observational study - Liver Int. 2023 Mar;43(3):695-707

Thomas Talbot, Antonio D'Alessio, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U. Marron, Tomi Jun, Sirish Dharmapuri, Celina Ang, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Claudia A. M. Fulgenzi, Suneetha Amara, Abdul Rafeh Naqash, Anuhya Gampa, Anjana Pillai, Yinghong Wang, Uqba Khan, Pei-Chang Lee, Yi-Hsiang Huang, Bertram Bengsch, Dominik Bettinger, Yehia I. Mohamed, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Masatoshi Kudo, Arndt Weinmann, Peter R. Galle, Ambreen Muhammed, Alessio Cortellini, Arndt Vogel, David J. Pinato

 

B7-H3 as a Therapeutic Target in Advanced Prostate Cancer - Eur Urol. 2023 Mar;83(3):224-238.

Christina Guo, Ines Figueiredo, Bora Gurel, Antje Neeb, George Seed, Mateus Crespo, Suzanne Carreira, Jan Rekowski, Lorenzo Buroni, Jon Welti, Denisa Bogdan, Lewis Gallagher, Adam Sharp, Maria D Fenor de la Maza, Pasquale Rescigno, Daniel Westaby, Khobe Chandran, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Bianca Calì, Andrea Alimonti, Silvia Bressan, Alana H T Nguyen, Michael M Shen, Jessica E Hawley, Aleksandar Obradovic, Charles G Drake, Claudia Bertan, Chloe Baker, Nina Tunariu, Wei YuanJohann S de Bono

 

Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer TargetingAdv Mater. 2023 Mar 11;e2300413.

Adam Creamer, Alessandra Lo Fiego, Alice Agliano, Lino Prados-Martin, Håkon Høgset, Adrian Najer, Daniel A. Richards, Jonathan P. Wojciechowski, James E. J. Foote, Nayoung Kim, Amy Monahan, Jiaqing Tang, André Shamsabadi, Léa N. C. Rochet, Ioanna A. Thanasi, Laura R. de la Ballina, Charlotte L. Rapley, Stephen Turnock, Elizabeth A. Love, Laurence Bugeon, Margaret J. Dallman, Martin Heeney, Gabriela Kramer-Marek, Vijay Chudasama, Federico Fenaroli, Molly M. Stevens

 

Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer. - Cancer Cell. 2023 Mar 13;41(3):602-619.e11.

Bancaro N, Calì B, Troiani M, Elia AR, Arzola RA, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D'Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Di Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Pereira Mestre R, Bolis M, Gillessen Sommer S, de Bono J, Calcinotto A, Alimonti A. 

 

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growthOncogene. 2023 Mar;42(12):926-937. 

Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann & Jennifer Munkley

 

PETAL protocol: a phase Ib study of pembrolizumab after transarterial chemoembolization in hepatocellular carcinoma - Future Oncol. 2023 Mar;19(7):499-507. doi: 10.2217/fon-2022-0916. 

Petros Fessas, Bernhard Scheiner, Antonio D'Alessio, Claudia A M Fulgenzi, James Korolewicz, Caroline Ward, Paul Tait, Robert Thomas, Alessio Cortellini, Rohini Sharma, David J Pinato

 

Apoptosis-modulatory miR-361-3p as a novel treatment target in endocrine-responsive and endocrine-resistant breast cancer - J Endocrinol. 2023 Feb 11;256(3):e220229.

J N Zamarbide Losada, E Sulpice, S Combe, G S Almeida, D A Leach, J Choo, L Protopapa, M P Hamilton, S McGuire, X Gidrol, C L BevanC E Fletcher

 

Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste T. Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber

 

Association Between Purchase of Over-the-Counter Medications and Ovarian Cancer Diagnosis in the Cancer Loyalty Card Study (CLOCS): Observational Case-Control Study - JMIR Public Health Surveill. 2023 Jan 26;9:e41762. 

Hannah R Brewer, Yasemin Hirst, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James M Flanagan

 

Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer - Gene. 2023 Jan 20;850:146930. 

Uttom Kumar, Marcos Castellanos-Uribe, Sean T May, Ernesto Yagüe

 

H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways - Reprod Biol Endocrinol. 2023 Jan 26;21(1):9.

María Cristina Carbajo-García, Elena Juarez-Barber, Marina Segura-Benítez, Amparo Faus, Alexandra Trelis, Javier Monleón, Greta Carmona-Antoñanzas, Antonio Pellicer, James M Flanagan, Hortensia Ferrero

 

A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res. 2023 Jan 17;29(2):331-340.

Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji

 

2022

Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice - Nat Protoc 2022 Dec 9.

May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens 

 

Immune Biomarkers in Metastatic Castration-resistant Prostate CancerEur Urol Oncol. 2022 Dec;5(6):659-667. 

María Dolores Fenor de la Maza, Khobe Chandran, Jan Rekowski, Irene M Shui, Bora Gurel, Emily Cross, Suzanne Carreira, Wei Yuan, Daniel Westaby, Susana Miranda, Ana Ferreira, George Seed, Mateus Crespo, Ines Figueiredo, Claudia Bertan, Veronica Gil, Ruth Riisnaes, Adam Sharp, Daniel Nava Rodrigues, Pasquale Rescigno, Nina Tunariu, Xiao Qiao Liu, Razvan Cristescu, Charles Schloss, Christina Yap, Johann S de Bono

 

Dissecting the Tumor Microenvironment to Predict Immunotherapy Response in Hepatocellular CancerGastroenterology. 2022 Dec;163(6):1712-1713. 

Antonio D'Alessio, David J Pinato

 

Proteome-wide structure-based accessibility analysis of ligandable and detectable cysteines in chemoproteomic datasets - BioRxiv

Matthew E. H. White, Jesús Gil, Edward W. Tate

 

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion - J Am Chem Soc

2022 Nov 22.

Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate

 

A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodulesEBioMedicine. 2022 Dec:86:104344. 

Benjamin Hunter, Mitchell Chen, Prashanthi Ratnakumar, Esubalew Alemu, Andrew Logan, Kristofer Linton-Reid, Daniel Tong, Nishanthi Senthivel, Amyn Bhamani, Susannah Bloch, Samuel V Kemp, Laura Boddy, Sejal Jain, Shafick Gareeboo, Bhavin Rawal, Simon Doran, Neal Navani, Arjun Nair, Catey Bunce, Stan Kaye, Matthew Blackledge, Eric O Aboagye, Anand Devaraj, Richard W Lee

 

Differential Expression of RSK4 Transcript Isoforms in Cancer and Its Clinical RelevanceInt J Mol Sci. 2022 Nov 23;23(23):14569.

Sisi Chen, Michael J Seckl, Marc P G Lorentzen, Olivier E Pardo

 

A multicentre study of pembrolizumab time-of-day infusion patterns and clinical outcomes in non-small-cell lung cancer: too soon to promote morning infusionsAnn Oncol. 2022 Nov;33(11):1202-1204.

A Cortellini, A P C Barrichello, J V Alessi, B Ricciuti, V R Vaz, T Newsom-Davis, J S Evans, G Lamberti, F Pecci, P Viola, A D'Alessio, C A M Fulgenzi, M M Awad, D J Pinato

 

A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res 2022 Nov 15;CCR-22-2074.

Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji

 

Multi-omics signatures of the human early life exposomeNat Commun. 2022 Nov 21;13(1):7024. 

Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Chatzi, Amrit K. Sakhi, Cathrine Thomsen, Ibon Tamayo, Mark Nieuwenhuijsen, Jose Urquiza, Eva Borràs, Eduard Sabidó, Inés Quintela, Ángel Carracedo, Xavier Estivill, Muireann Coen, Juan R. González, Hector C. Keun & Martine Vrijheid

 

Epigenetic potentiation of somatostatin-2 by guadecitabine in neuroendocrine neoplasias as a novel method to allow delivery of peptide receptor radiotherapyEur J Cancer. 2022 Nov:176:110-120. 

Joanne S Evans, Jamie Beaumont, Marta Braga, Nahal Masrour, Francesco Mauri, Alice Beckley, Shamus Butt, Christina S Karali, Chris Cawthorne, Stephen Archibald, Eric O Aboagye, Rohini Sharma

 

Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)-A Prospective Pilot Study of Diagnostic AccuracyCancers (Basel). 2022 Nov 29;14(23):5892.

Diana Marcus, David L Phelps, Adele Savage, Julia Balog, Hiromi Kudo, Roberto Dina, Zsolt Bodai, Francesca Rosini, Jacey Ip, Ala Amgheib, Julia Abda, Eftychios Manoli, James McKenzie, Joseph Yazbek, Zoltan Takats, Sadaf Ghaem-Maghami

 

A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer - Clin Cancer Res 2022 Nov 1;28(21):4634-4641.

Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, Alvaro Ingles Garces, Andrea Biondo, Ionut-Gabriel Funingana, Martin Little, Ruth Ruddle, Florence Raynaud, Ruth Riisnaes, Bora Gurel, Sue Chua, Nina Tunariu, Joanna C Porter, Toby Prout, Mona Parmar, Anna Zachariou, Alison Turner, Ben Jenkins, Stuart McIntosh, Ed Ainscow, Anna Minchom, Juanita Lopez, Johann de Bono, Robert Jones, Emma Hall, Natalie Cook, Bristi Basu, Udai Banerji

 

Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy - J Microsc 2022 Nov;288(2):130-141.

Jonathan Lightley, Frederik Görlitz, Sunil Kumar, Ranjan Kalita, Arinbjorn Kolbeinsson, Edwin Garcia, Yuriy Alexandrov, Vicky Bousgouni, Riccardo Wysoczanski, Peter Barnes, Louise Donnelly, Chris BakalChristopher Dunsby, Mark A A Neil, Seth Flaxman, Paul M W French

 

Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin AssessmentJAMA Surg 2022 Nov 1;157(11):e223899.

Scarlet Nazarian, Ioannis Gkouzionis, Michal Kawka, Marta Jamroziak, Josephine Lloyd, Ara Darzi, Nisha Patel, Daniel S Elson, Christopher J Peters

 

Robotic large-area optical biopsy imaging for automated detection of gastrointestinal cancers tested in tissue phantoms and ex vivo porcine bowel - Transl Biophotonics Biophotonics and Robotics Volume5, Issue2

Fernando B. Avila-Rencoret, George P. Mylonas, Daniel S. Elson

 

Detection of YAP1 and AR-V7 mRNA for Prostate Cancer Prognosis Using an ISFET Lab-On-Chip Platform - ACS Sens 

2022 Nov 11. doi: 10.1021/acssensors.2c01463. 

Joseph Broomfield, Melpomeni Kalofonou, Thomas Pataillot-Meakin, Sue M Powell, Rayzel C Fernandes, Nicolas Moser, Charlotte L BevanPantelis Georgiou

 

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance - Cancer Res. 2022 Nov 2;82(21):3962-3973.

Llorca-Cardenosa MJ, Aronson LI, Krastev DB, Nieminuszczy J, Alexander J, Song F, Dylewska M, Broderick R, Brough R, Zimmermann A, Zenke FT, Gurel B, Riisnaes R, Ferreira A, Roumeliotis T, Choudhary J, Pettitt SJ, de Bono J, Cervantes A, Haider S, Niedzwiedz W, Lord CJ, Chong IY. 

 

Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells - Commun Biol 2022 Nov 11;5(1):1178.

Peter Quicke, Yilin Sun, Mar Arias-Garcia, Melina Beykou, Corey D Acker, Mustafa B A Djamgoz, Chris Bakal, Amanda J Foust

 

Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer - Oncogene  2022 Oct 5.

Alison Harrod, Chun-Fui Lai, Isabella Goldsbrough, Georgia M. Simmons, Natasha Oppermans, Daniela B. Santos, Balazs Győrffy, Rebecca C. Allsopp, Bradley J. Toghill, Kirsty Balachandran, Mandy Lawson, Christopher J. Morrow, Manasa Surakala, Larissa S. Carnevalli, Pei Zhang, David S. Guttery, Jacqueline A. Shaw, R. Charles Coombes, Lakjaya Buluwela, Simak Ali

 

Gross tumour volume radiomics for prognostication of recurrence & death following radical radiotherapy for NSCLCNPJ Precis Oncol. 2022 Oct 27;6(1):77.

Sumeet Hindocha, Thomas G. Charlton, Kristofer Linton-Reid, Benjamin Hunter, Charleen Chan, Merina Ahmed, Emily J. Greenlay, Matthew Orton, Catey Bunce, Jason Lunn, Simon J. Doran, Shahreen Ahmad, Fiona McDonald, Imogen Locke, Danielle Power, Matthew Blackledge, Richard W. Lee & Eric O. Aboagye

 

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications - Cells. 2022 Oct 19;11(20):3286.

Naseem A, Pal A, Gowan S, Asad Y, Donovan A, Temesszentandrási-Ambrus C, Kis E, Gaborik Z, Bhalay G, Raynaud F. 

 

Deep-learned estimation of uncertainty in measurements of apparent diffusion coefficient from whole-body diffusion-weighted MRI - Comput Biol Med. 2022 Oct;149:106091.

Zormpas-Petridis K, Tunariu N, Collins DJ, Messiou C, Koh DM, Blackledge MD. 

 

Optimising CT-guided biopsies of sclerotic bone lesions in cancer patientsEur Radiol. 2022 Oct;32(10):6820-6829.

Ricardo Donners, Nicos Fotiadis, Ines Figueiredo, Matthew Blackledge, Daniel Westaby, Christina Guo, Maria de los Dolores Fenor de la Maza, Dow-Mu Koh & Nina Tunariu 

 

Patient communication in radiology: Moving up the agendaEur J Radiol. 2022 Oct;155:110464.

Andrea G Rockall, Caroline Justich, Thomas Helbich, Valerie Vilgrain

 

Comparative efficacy of novel combination strategies for unresectable hepatocellular carcinoma: A network metanalysis of phase III trials - Eur J Cancer. 2022 Oct;174:57-67. 

Claudia A M Fulgenzi, Antonio D'Alessio, Chiara Airoldi, Lorenza Scotti, Coskun O Demirtas, Alessandra Gennari, Alessio Cortellini, David J Pinato

 

Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative DisordersACS Appl Mater Interfaces 2022 Oct 26;14(42):47445-47460.

Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie K Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michal Klosowski, Robert J Wilkinson, Roland A Fleck, Fang Xie, Alexandra E Porter, Darya Kiryushko

 

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma - Oncogene  2022 Sep 10.

Theodore Evan, Victoria Min-Yi Wang , Axel Behrens

 

Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cellsRSC Adv. 2022 Sep 15;12(40):26372-26381.

Diana Brickute, Cen Chen, Marta Braga, Chris Barnes, Ning Wang, Louis Allott, Eric O Aboagye

 

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP- PROTACs)Chem Commun (Camb). 2022 Sep 29;58(78):10933-10936.

Qisi Zhang, Cyrille S Kounde, Milon Mondal, Jake L Greenfield, Jennifer R Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D Harling, Matthew J Fuchter, Edward W Tate

 

Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies Breast Cancer Res. 2022 Sep 6;24(1):59.

Pierre-Antoine Dugué, Clara Bodelon, Felicia F. Chung, Hannah R. Brewer, Srikant Ambatipudi, Joshua N. Sampson, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Giovanni Fiorito, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Paolo Vineis, Silvia Polidoro, Laura Baglietto, Dallas English, Gianluca Severi, Graham G. Giles, Roger L. Milne, Zdenko Herceg, Montserrat Garcia-Closas, James M. Flanagan & Melissa C. Southey 

 

Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapyJ Mater Chem B. 2022 Sep 28;10(37):7491-7511.

Srinivas Balagopal, Koichi Sasaki, Pooja Kaur, Maria Nikolaidi, Jun Ishihara 

 

Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphomaBr J Cancer. 2022 Sep;127(5):937-947

Richard A. Noble, Huw Thomas, Yan Zhao, Lili Herendi, Rachel Howarth, Ilaria Dragoni, Hector C. Keun, Christopher P. Vellano, Joseph R. Marszalek & Stephen R. Wedge

 

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Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. TateDoryen Bubeck

 

Robust, single-shot, optical autofocus system utilizing cylindrical lenses to provide high precision and long range of operation - BioRxiv 2022.07.14.498938.

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Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition Scientific Data volume 9, Article number: 395 (2022).

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GREM1 is required to maintain cellular heterogeneity in pancreatic cancer - Nature volume 607, pages163–168 (2022).

Linxiang Lan, Theodore Evan, Huafu Li, Aasia Hussain, E. Josue Ruiz, May Zaw Thin, Rute M. M. Ferreira, Hari Ps, Eva M. Riising, Yoh Zen, Jorge Almagro, Kevin W. Ng, Pablo Soro-Barrio, Jessica Nelson, Gabriela Koifman, Joana Carvalho, Emma L. Nye, Yulong He, Changhua Zhang, Anguraj Sadanandam & Axel Behrens 

 

Microfluidic T Cell Selection by Cellular Avidity - Adv Healthc Mater  2022 Aug;11(16):e2200169.

Julian F. Ashby, Julien Schmidt, Neelima KC, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H. Au

 

Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer - Clin Cancer Res. 2022 Aug 15;28(16):3509-3525.

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Capturing pore-forming intermediates of MACPF and binary toxin assemblies by cryoEM - Curr Opin Struct Biol 2022 Aug;75:102401.

Emma C CouvesDoryen Bubeck

 

Variational Bayes for high-dimensional proportional hazards models with applications within gene expression - Bioinformatics. 2022 Aug 10;38(16):3918-3926.

Michael Komodromos, Eric O Aboagye, Marina Evangelou, Sarah Filippi, Kolyan Ray

 

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation - BioRviv 2022.07.21.500987

José Almeida-Santos, Rita Berkachy, Chanidapa Adele Tye, Jehanne Hassan, Bahire Kalfaoglu, Murray E. Selkirk, Masahiro Ono

 

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade - BioRvix 2022.07.19.500582.

Jehanne Hassan, Elizabeth Appleton, Bahire Kalfaoglu, Malin Pedersen, José Almeida-Santos, Hisashi Kanemaru, Nobuko Irie, Shane Foo, Omnia Reda, Benjy J.Y. Tan, Il-mi Okazaki, Taku Okazaki, Yorifumi Satou, Kevin Harrington, Alan MelcherMasahiro Ono

 

ArTisaN trial protocol: a single Centre, open-label, phase II trial of the safety and efficacy of TheraSphere selective internal radiation therapy (SIRT) in the treatment of inoperable metastatic (liver) neuroendocrine neoplasia (NENs) BMC Cancer. 2022 Jul 20;22(1):800.

Rohini Sharma, Susanna Slater, Joanne Evans, Maria Martinez, Caroline Ward, Hooshang Izadi, Florian Wernig, Rob Thomas

 

Multiparametric bone MRI can improve CT-guided bone biopsy target selection in cancer patients and increase diagnostic yield and feasibility of next-generation tumour sequencing - Eur Radiol. 2022 Jul;32(7):4647-4656.

Donners R, Figueiredo I, Tunariu N, Blackledge M, Koh DM, de la Maza MLDF, Chandran K, de Bono JS, Fotiadis N. 

 

The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma Clin Cancer Res. 2022 Jul 1;28(13):2911-2922.

Zhao Cheng, Hasan Mirza, Darren P Ennis, Philip Smith, Lena Morrill Gavarró, Chishimba Sokota, Gaia Giannone, Theodora Goranova, Thomas Bradley, Anna Piskorz, Michelle Lockley; BriTROC-1 Investigators; Baljeet Kaur, Naveena Singh, Laura A Tookman, Jonathan Krell, Jacqueline McDermott, Geoffrey Macintyre, Florian Markowetz, James D Brenton, Iain A McNeish

 

Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer Clin Cancer Res. 2022 Jul 15;28(14):3104-3115.

Beshara Sheehan, Antje Neeb, Lorenzo Buroni, Alec Paschalis, Ruth Riisnaes, Bora Gurel, Veronica Gil, Susana Miranda, Mateus Crespo, Christina Guo, Juan Jiménez Vacas, Ines Figueiredo, Ana Ferreira, Jon Welti, Wei Yuan, Suzanne Carreira, Adam Sharp, Johann de Bono

 

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer - Nature Communications volume 13, Article number: 2070 (2022).

Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker & Axel Behrens 

 

Adenoma characteristics associated with post-polypectomy proximal colon cancer incidence: a retrospective cohort studyBr J Cancer 2022 Jun;126(12):1744-1754.

Rhea Harewood, Kate Wooldrage, Emma C Robbins, James Kinross, Christian von Wagner, Amanda J Cross

 

Does the addition of whole-body MRI to routine imaging influence real-world treatment decisions in metastatic breast cancer? - Cancer Imaging. 2022 Jun 7;22(1):26.

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Lateral flow assays for hormone detectionLab Chip. 2022 Jun 28;22(13):2451-2475.

Leena Khelifa, Yubing Hu, Nan Jiang, Ali K Yetisen

 

Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumorsJ Immunother Cancer 2022 Jun;10(6):e004495.

Dionysis Papadatos-Pastos, Wei Yuan, Abhijit Pal, Mateus Crespo, Ana Ferreira, Bora Gurel, Toby Prout, Malaka Ameratunga, Maxime Chénard-Poirier, Andra Curcean, Claudia Bertan, Chloe Baker, Susana Miranda, Nahal Masrour, Wentin Chen, Rita Pereira, Ines Figueiredo, Ricardo Morilla, Ben Jenkins, Anna Zachariou, Ruth Riisnaes, Mona Parmar, Alison Turner, Suzanne Carreira, Christina Yap, Robert Brown, Nina Tunariu, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom

 

Tissue architecture in tumor initiation and progressionTrends Cancer  2022 Jun;8(6):494-505.

Jorge Almagro, Hendrik A Messal, Alberto Elosegui-Artola, Jacco van Rheenen, Axel Behrens

 

Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancerNat Commun. 2022 Jun 10;13(1):3246.

R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, V. Ferguson & M. J. Seckl

 

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic ChangesMol Cancer Ther 2022 Jun 1;21(6):1020-1029.

Elizabeth A Coker, Adam Stewart, Bugra Ozer, Anna Minchom, Lisa Pickard, Ruth Ruddle, Suzanne Carreira, Sanjay Popat, Mary O'Brien, Florence Raynaud, Johann de Bono, Bissan Al-Lazikani, Udai Banerji

 

Simultaneous Depth Estimation and Surgical Tool Segmentation in Laparoscopic ImagesIEEE Trans Med Robot Bionics. 2022 May;4(2):335-338. 

Baoru Huang, Anh Nguyen, Siyao Wang, Ziyang Wang, Erik Mayer, David Tuch, Kunal Vyas, Stamatia Giannarou, Daniel S Elson 

 

Fully automated deep-learning section-based muscle segmentation from CT images for sarcopenia assessmentClin Radiol. 2022 May;77(5):e363-e371.

S. Islam, F. Kanavati, Z. Arain, O. Fadeeva Da Costa, W. Crum, E.O. Aboagye, A.G. Rockall 

 

Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility studyLancet Oncol. 2022 May;23(5):682-690.

Paul T R Thiruchelvam, Daniel R Leff, Amy R Godden, Susan Cleator, Simon H Wood, Anna M Kirby, Navid Jallali, Navita Somaiah, Judith E Hunter, Francis P Henry, Aikaterini Micha, Rachel L O'Connell, Kabir Mohammed, Neill Patani, Melissa L H Tan, Dorothy Gujral, Gillian Ross, Stuart E James, Aadil A Khan, Jennifer E Rusby, Dimitri J Hadjiminas, Fiona A MacNeill; PRADA Trial Management Group

 

Self-supervised Monocular Depth Estimation with 3D Displacement Module for Laparoscopic ImagesIEEE Trans Med Robot Bionics. 2022 May;4(2):331-334.

Chi Xu, Baoru Huang, Daniel S Elson

 

Risk Factors for Ovarian Cancer: An Umbrella Review of the LiteratureCancers (Basel). 2022 May 30;14(11):2708.

Eilbhe Whelan, Ilkka Kalliala, Anysia Semertzidou, Olivia Raglan, Sarah Bowden, Konstantinos Kechagias, Georgios Markozannes, Sofia Cividini, Iain McNeish, Julian Marchesi, David MacIntyre, Phillip Bennett, Kostas Tsilidis, Maria Kyrgiou

 

Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-careSci Rep. 2022 May 24;12(1):8750.

Benjamin W Wormald, Nicolas Moser, Nandita M deSouza, Katerina-Theresa Mantikas, Kenny Malpartida-Cardenas, Ivana Pennisi, Thomas E J Ind, Katherine Vroobel, Melpomeni Kalofonou, Jesus Rodriguez-Manzano, Pantelis Georgiou


A systematic review of robotic surgery: From supervised paradigms to fully autonomous robotic approaches - Int J Med Robot 2022 Apr;18(2):e2358.

Jinpei Han, Joseph Davids, Hutan Ashrafian, Ara Darzi, Daniel S Elson, Mikael Sodergren

 

Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic CombinationsOnco Targets Ther. 2022 Apr 28:15:437-468. 

Marcin Niedbała, Katarzyna Malarz, Gitanjali Sharma, Gabriela Kramer-Marek, Wojciech Kaspera

 

Not as simple as "fear of the unknown": A qualitative study exploring anxiety in the radiotherapy department - Eur J Cancer Care (Engl) 2022 Mar;31(2):e13564.

Eliza Gimson, Maria Greca Dottori, Gemma Clunie, Caroline Yan Zheng, Theresa Wiseman, Elizabeth Joyce, Alison McGregorHelen McNair

 

Patient and practitioner perspectives on the design of a simulated affective touch device to reduce procedural anxiety associated with radiotherapy: a qualitative studyBMJ Open. 2022 Mar 16;12(3):e050288.

Hugo Hall, Yasmin Dhuga, Caroline Yan Zheng, Gemma Clunie, Elizabeth Joyce, Helen McNair, Alison H McGregor

 

Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors - J Clin Invest 2022 Mar 15;132(6):e142137.

Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C Quarles, Deborah R Healey, Yijie Guo, Manuel Luis Orta-Vázquez, Santiago Mateos-Cordero, Khalid Shah, John Bomalaski, Giulio Anichini, Andreas G Tzakos, Timothy Crook, Kevin O'Neill, Adrienne C Scheck, Jose Luis Venero, Nelofer Syed

 

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicityJ Extracell Vesicles. 2022 Mar;11(3):e12199.

Kai Hu, Paul F McKay, Karnyart Samnuan, Adrian Najer, Anna K Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M Stevens, Robin J Shattock

 

A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancerMol Cancer. 2022 Mar 22;21(1):82.

C E Fletcher, L Deng, F Orafidiya, W Yuan, M P G S Lorentzen, O W Cyran, A Varela-Carver, T A Constantin, D A Leach, F M Dobbs, I Figueiredo, B Gurel, E Parkes, D Bogdan, R R Pereira, S G Zhao, A Neeb, F Issa, J Hester, H Kudo, Y Liu, Y Philippou, R Bristow, K Knudsen, R J Bryant, F Y Feng, S H Reed, I G Mills, J de Bono, C L Bevan

 

Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastomaNat Commun 2022 Mar 16;13(1):1380. 

Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, Evon Poon, Clare Eckold, Gabriel N Valbuena, Yuewei Xu, Yusong Liu, Barbara Martins da Costa, Michael Gruet, Chiharu Wickremesinghe, Adrian Benito, Holger Kramer, Alex Montoya, David Carling, Elizabeth J Want, Yann Jamin, Louis Chesler, Hector C Keun

 

A comparison of machine learning methods for predicting recurrence and death after curative-intent radiotherapy for non-small cell lung cancer: Development and validation of multivariable clinical prediction modelsEBioMedicine. 2022 Mar:77:103911.

Sumeet Hindocha, Thomas G Charlton, Kristofer Linton-Reid, Benjamin Hunter, Charleen Chan, Merina Ahmed, Emily J Robinson, Matthew Orton, Shahreen Ahmad, Fiona McDonald, Imogen Locke, Danielle Power, Matthew Blackledge, Richard W Lee, Eric O Aboagye.

 

The Role of Artificial Intelligence in Early Cancer DiagnosisCancers (Basel). 2022 Mar 16;14(6):1524.

Benjamin Hunter, Sumeet Hindocha, Richard W Lee

 

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma - J Immunother Cancer 2022 Mar;10(3):e004410.

Galabina Bozhanova, Jehanne HassanLizzie Appleton, Victoria Jennings, Shane Foo, Martin McLaughlin, Charleen Ml Chan Wah Hak, Emmanuel C Patin, Eva Crespo-Rodriguez, Gabby Baker, Edward Armstrong, Matthew Chiu, Hardev Pandha, Adel Samson, Victoria Roulstone, Joan Kyula, Richard Vile, Fiona Errington-Mais, Malin Pedersen, Kevin Harrington, Masahiro OnoAlan Melcher

 

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicityJ Extracell Vesicles 2022 Mar;11(3):e12199.

Kai Hu, Paul F McKay, Karnyart Samnuan, Adrian Najer, Anna K Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M Stevens, Robin J Shattock

 

Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgeryJ Biomed Opt 2022 Feb;27(2):025001. 

Ioannis Gkouzionis, Scarlet Nazarian, Michal Kawka, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

 

MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public dataBr J Cancer. 2022 Feb;126(3):502-513.

Sharmila Rana, Gabriel N Valbuena, Ed Curry, Charlotte L Bevan, Hector C Keun

 

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy - BMC Med 2022 Jan 21;20(1):16. 

Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera & Gabriela Kramer-Marek

 

A New Old Target: Androgen Receptor Signaling and Advanced Prostate CancerAnnu Rev Pharmacol Toxicol. 2022 Jan 6:62:131-153.

Daniel Westaby, Maria de Los Dolores Fenor de La Maza, Alec Paschalis, Juan M Jimenez-Vacas, Jon Welti, Johann de Bono, Adam Sharp

 

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosisElife. 2022 Jan 11:11:e72579.

Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo

 

Technologies for Size-Based Analysis of Circulating Cell-Free DNA: Limitations and Clinical ImplementationCrit Rev Oncog 2022;27(1):97-108. 

Thomas Pataillot-Meakin, Sylvain Ladame, Charlotte Bevan

2021

 

HER3 Is an Actionable Target in Advanced Prostate CancerCancer Res. 2021 Dec 15;81(24):6207-6218.  

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D'Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M Shen, Andrea Alimonti, Antje Neeb, Jonathan Welti, Wei Yuan, Johann de Bono; PCF/SU2C International Prostate Cancer Dream Team

 

Daniel Westaby, Juan M Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P Balk, Johann S de Bono, Adam Sharp

 

The systemic inflammatory response identifies patients with adverse clinical outcome from immunotherapy in hepatocellular carcinomaCancers (Basel). 2021 Dec 31;14(1):186.

Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J Pinato

 

Strategies to implement SARS-CoV-2 point-of-care testing into primary care settings: a qualitative secondary analysis guided by the Behaviour Change Wheel Implement Sci Commun. 2021 Dec 18;2(1):139.

Patrick Kierkegaard, Timothy Hicks, A Joy Allen, Yaling Yang, Gail Hayward, Margaret Glogowska, Brian D Nicholson, Peter Buckle; CONDOR Steering Committee

 

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas - Cell Stem Cell 2021 Nov 4;28(11):2000-2008.e4.

Christopher Gribben, Christopher Lambert, Hendrik A Messal, Ella-Louise Hubber, Chloe Rackham, Ian Evans, Harry Heimberg, Peter Jones, Rocio Sancho, Axel Behrens

 

Loop-Mediated Isothermal Amplification Assay for Detecting Tumor Markers and Human Papillomavirus: Accuracy and Supplemental Diagnostic Value to Endovaginal MRI in Cervical Cancer Front. Oncol., 01 November 2021.

Benjamin Wormald, Jesus Rodriguez-Manzano, Nicolas Moser, Ivana Pennisi, Thomas E. J. Ind, Katherine Vroobel, Ayoma Attygalle, Pantelis Georgiou and Nandita M. deSouza

 

Treatment-related toxicity and improved outcome from immunotherapy in hepatocellular cancer: Evidence from an FDA pooled analysis of landmark clinical trials with validation from routine practiceEur J Cancer. 2021 Nov;157:140-152.

David J. Pinato, Thomas U. Marron, Pallavi Shruti Mishra-Kalyani, Yutao Gong, Guo Wei, David Szafron, Elad Sharon, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Abdul R. Naqash, Thoetchai Peeraphatdit, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Chieh J. Lee, Pei-Chang Lee, Anushi Bulumulle […] Lorraine Pelosof

 

Efficient Table-Based Polynomial on FPGA - IEEE

Marco Barbone; Bas W. Kwaadgras; Uwe Oelfke; Wayne Luk; Georgi Gaydadjiev

 

Antibiotic-exposed patients with non-small-cell lung cancer preserve efficacy outcomes following first-line chemo-immunotherapyAnn Oncol. 2021 Nov;32(11):1391-1399.

A Cortellini, B Ricciuti, F Facchinetti, J V M Alessi, D Venkatraman, F G Dall'Olio, P Cravero, V R Vaz, D Ottaviani, M Majem, A Piedra, I Sullivan, K A Lee, G Lamberti, N Hussain, J Clark, A Bolina, A Barba, J C Benitez, T Gorría, L Mezquita, D Hoton, F Aboubakar Nana, B Besse, M M Awad, D J Pinato

 

A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles Chem Commun (Camb). 2021 Nov 4;57(88):11677-11680. 

Jin Hui Teh, Marta Braga, Louis Allott, Chris Barnes, Javier Hernández-Gil, Meng-Xing Tang, Eric O Aboagye, Nicholas J Long

 

Development of a Structured Query Language and Natural Language Processing Algorithm to Identify Lung Nodules in a Cancer CentreFront Med (Lausanne). 2021 Nov 4:8:748168. 

Benjamin Hunter, Sara Reis, Des Campbell, Sheila Matharu, Prashanthi Ratnakumar, Luca Mercuri, Sumeet Hindocha, Hardeep Kalsi, Erik Mayer, Ben Glampson, Emily J Robinson, Bisan Al-Lazikani, Lisa Scerri, Susannah Bloch, Richard Lee

 

Immune Checkpoint Inhibitor and Radiotherapy-Related Pneumonitis: An Informatics Approach to Determine Real-World Incidence, Severity, Management, and Resource ImplicationsFront Med (Lausanne). 2021 Nov 1:8:764563.

Sumeet Hindocha, Des Campbell, Merina Ahmed, Kyriaki Giorgakoudi, Bhupinder Sharma, Nadia Yousaf, Philip Molyneaux, Benjamin Hunter, Hardeep Kalsi, Wanyuan Cui, Michael Davidson, Jaishree Bhosle, Anna Minchom, Imogen Locke, Fiona McDonald, Mary O'Brien, Sanjay Popat, Richard W Lee

 

Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approachPLoS One. 2021 Nov 18;16(11):e0260186.

Marta Braga, Chee Hau Leow, Javier Hernandez Gil, Jin H. Teh, Laurence Carroll, Nicholas J. Long, Meng-Xing TangEric O. Aboagye

 

Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer? -  Prostate Cancer Prostatic Dis 2021 Nov 29.

Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed, Mathias Winkler

 

The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasiaGenome Med. 2021 Nov 4;13(1):176.

Anita Mitra, David A. MacIntyre, Maria Paraskevaidi, Anna-Barbara Moscicki, Vishakha Mahajan, Ann Smith, Yun S. Lee, Deirdre Lyons, Evangelos Paraskevaidis, Julian R. Marchesi, Phillip R. Bennett & Maria Kyrgiou

 

Tissue clearing to examine tumour complexity in three dimensions - Nat Rev Cancer 2021 Nov;21(11):718-730.

Jorge Almagro, Hendrik A Messal, May Zaw Thin, Jacco van Rheenen, Axel Behrens

 

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation - Nat Protoc 2021 Nov;16(11):5083-5122.

Wouter W Kallemeijn, Thomas Lanyon-Hogg, Nattawadee Panyain, Andrea Goya Grocin, Paulina Ciepla, Julia Morales-Sanfrutos, Edward W Tate

 

An enhanced marker pattern that achieves improved accuracy in surgical tool trackingCOMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 2022, VOL. 10, NO. 4, 400–408.

João Cartucho, Chiyu Wang, Baoru Huang, Dan S. ElsonAra Darzi, and Stamatia Giannarou

 

VisionBlender: a tool to efficiently generate computer vision datasets for robotic surgery - COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, Volume 9, 2021 - Issue 4: Special Issue: AE-CAI 2020

João Cartucho, Samyakh Tukra, Yunpeng Li, Daniel S. Elson & Stamatia Giannarou

 

Implementing lateral flow devices in long-term care facilities: experiences from the Liverpool COVID-19 community testing pilot in care homes- a qualitative study - BMC Health Serv Res 2021 Oct 25;21(1):1153.

Patrick Kierkegaard, Massimo Micocci, Anna McLister, John S P Tulloch, Paula Parvulescu, Adam L Gordon, Peter Buckle

 

Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint BlockadeFront Immunol. 2021 Oct 18:12:754436.

Elizabeth Appleton, Jehanne Hassan, Charleen Chan Wah Hak, Nanna Sivamanoharan, Anna Wilkins, Adel Samson, Masahiro Ono, Kevin J Harrington, Alan Melcher, Erik Wennerberg

 

MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cellsBiochem Pharmacol. 2021 Oct;192:114692.

Uttom Kumar, Yunhui Hu, Nahal Masrour, Marcos Castellanos-Uribe, Alison Harrod, Sean T May, Simak Ali, Valerie Speirs, R Charles Coombes, Ernesto Yagüe

 

Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity - Trends Pharmacol Sci 2021 Oct;42(10):870-882.

Andrea Goya Grocin, Wouter W Kallemeijn, Edward W Tate

 

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma -  Elife 2021 Oct 12;10:e71596.

E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens

 

Structural basis of soluble membrane attack complex packaging for clearance - Nat Commun 2021 Oct 19;12(1):6086.

Anaïs Menny, Marie V Lukassen, Emma C Couves, Vojtech Franc, Albert J R Heck, Doryen Bubeck

 

Medication use and risk of proximal colon cancer: a systematic review of prospective studies with narrative synthesis and meta-analysis - Cancer Causes Control 2021 Oct;32(10):1047-1061.

Rhea Harewood, Ruth Disney, James Kinross, Christian von Wagner, Amanda J Cross

 

Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapyJ Immunother Cancer. 2021 Sep;9(9):e003311. 

David J Pinato, Sam M Murray, Alejandro Forner, Takahiro Kaneko, Petros Fessas, Pierluigi Toniutto, Beatriz Mínguez, Valentina Cacciato, Claudio Avellini, Alba Diaz, Rosemary J Boyton, Daniel M Altmann, Robert D Goldin, Ayse U Akarca, Teresa Marafioti, Francesco A Mauri, Edoardo Casagrande, Federica Grillo, Edoardo Giannini, Sherrie Bhoori, Vincenzo Mazzaferro

 

Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer: The REACT Randomized Clinical Trial JAMA Oncol. 2021 Sep 1;7(9):1291-1301.

R Charles Coombes, Holly Tovey, Lucy Kilburn, Janine Mansi, Carlo Palmieri, John Bartlett, Jonathan Hicks, Andreas Makris, Abigail Evans, Sibylle Loibl, Carsten Denkert, Elisabeth Murray, Robert Grieve, Robert Coleman, Annabel Borley, Marcus Schmidt, Beate Rautenberg, Catarina Alisa Kunze, Uwe Rhein, Keyur Mehta, Kelly Mousa, Tessa Dibble, Xiao Lou Lu, Gunter von Minckwitz, Judith M Bliss; Randomized European Celecoxib Trial (REACT) Trial Management Group and Investigators

 

Evaluating the impact of COVID-19 on supportive care needs, psychological distress and quality of life in UK cancer survivors and their support networkEur J Cancer Care (Engl). 2021 Sep;30(5):e13442.

Nicholas J. Hulbert-Williams, Monica Leslie, Lee Hulbert-Williams, Eilidh Smith, Lesley Howells, David J. Pinato

 

Carfilzomib Enhances the Suppressive Effect of Ruxolitinib in Myelofibrosis Cancers (Basel). 2021 Sep 28;13(19):4863.

Simone Claudiani, Clinton C Mason, Dragana Milojkovic, Andrea Bianchi, Cristina Pellegrini, Antinisca Di Marco, Carme R Fiol, Mark Robinson, Kanagaraju Ponnusamy, Katya Mokretar, Avirup Chowdhury, Michael Albert, Alistair G Reid, Michael W Deininger, Kikkeri Naresh, Jane F Apperley, Jamshid S Khorashad

 

Arresting metastasis within the microcirculation - Clin Exp Metastasis 2021 Aug;38(4):337-342.

Angelos Varotsos Vrynas, Julia Perea PaizalChris BakalSam H Au

 

PD-1 Blockade for Hepatocellular Carcinoma: Current Research and Future Prospects - J Hepatocell Carcinoma  2021 Aug 5;8:887-897.

Antonio D'Alessio, Lorenza Rimassa, Alessio Cortellini, David James Pinato

 

Consideration of Metabolite Efflux in Radiolabelled Choline KineticsPharmaceutics. 2021 Aug 12;13(8):1246. 

Yunqing Li, Marianna Inglese, Suraiya Dubash, Chris Barnes, Diana Brickute, Marta Costa Braga, Ning Wang, Alice Beckley, Kathrin Heinzmann, Louis Allott, Haonan Lu, Cen Chen, Ruisi Fu, Laurence Carroll, Eric O Aboagye

 

Lipidomic Profiling of Colorectal Lesions for Real-Time Tissue Recognition and Risk-Stratification using Rapid Evaporative Ionisation Mass Spectrometry - Ann Surg 2021 Aug 13.

Sam E Mason, Eftychios Manoli, James L Alexander, Liam Poynter, Lauren Ford, Petra Paizs, Afeez Adebesin, James S McKenzie, Francesca Rosini, Rob Goldin, Ara Darzi, Zoltan TakatsJames M Kinross

 

AL-PHA beads: Bioplastic-based protease biosensors for global health applications - MaterialsToday Volume 47, July–August 2021.

Richard J.R. Kelwick, Alexander J. Webb, Yizhou Wang, Amelie Heliot, Fiona Allan, Aidan M. Emery, Michael R. Templeton, Paul S. Freemont

 

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer - JCI Insight 2021 Jul 8;6(13):e124985.

E Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens

 

Anna Malczewska, Adam E Frampton, Mireia Mato Prado, Shima Ameri, Aleksandra F Dabrowska, Sladjana Zagorac, Ashley K Clift, Beata Kos-Kudła, Omar Faiz, Justin Stebbing, Leandro Castellano, Andrea Frilling

 

Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019Pharmaceutics. 2021 Jul 14;13(7):1078.

Ning Wang, Diana Brickute, Marta Braga, Chris Barnes, Haonan Lu, Louis Allott, Eric O Aboagye

 

Genetics of gestational trophoblastic diseaseBest Pract Res Clin Obstet Gynaecol. 2021 Jul;74:29-41.

Rosemary A Fisher, Geoffrey J Maher

 

Vessela Vassileva, Marta Braga, Chris Barnes, Justyna Przystal, Ali Ashek, Louis Allott, Diana Brickute, Joel Abrahams, Keittisak Suwan, Angel M Carcaboso, Amin Hajitou, Eric O Aboagye

 

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer - Sci Transl Med 2021 Jul 14;13(602):eaba4627.

Stelios Chrysostomou, Rajat Roy, Filippo Prischi, Lucksamon Thamlikitkul, Kathryn L Chapman, Uwais Mufti, Robert Peach, Laifeng Ding, David Hancock, Christopher Moore, Miriam Molina-Arcas, Francesco Mauri, David J Pinato, Joel M Abrahams, Silvia Ottaviani, Leandro Castellano, Georgios Giamas, Jennifer Pascoe, Devmini Moonamale, Sarah Pirrie, Claire Gaunt, Lucinda Billingham, Neil M Steven, Michael Cullen, David Hrouda, Mathias Winkler, John Post, Philip Cohen, Seth J Salpeter, Vered Bar, Adi Zundelevich, Shay Golan, Dan Leibovici, Romain Lara, David R Klug, Sophia N Yaliraki, Mauricio Barahona, Yulan Wang, Julian Downward, J Mark Skehel, Maruf M U Ali, Michael J SecklOlivier E Pardo

 

A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target - ACS Chem Biol

2021 Jun 18;16(6):982-990.

Cassandra R Kennedy, Andrea Goya Grocin, Tristan Kovačič, Ravi Singh, Jennifer A Ward, Avinash R Shenoy, Edward W Tate        

 

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum - Nat Commun 2021 Jun 10;12(1):3515.

Shenglin Cai, Thomas Pataillot-Meakin, Akifumi Shibakawa, Ren Ren, Charlotte L BevanSylvain Ladame, Aleksandar P Ivanov, Joshua B Edel

 

A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer - J Am Chem Soc 2021 Jun 16;143(23):8911-8924. 

Scott Lovell, Leran Zhang, Thomas Kryza, Anna Neodo, Nathalie Bock, Elena De Vita, Elizabeth D Williams, Elisabeth Engelsberger, Congyi Xu, Alexander T Bakker, Maria Maneiro, Reiko J Tanaka, Charlotte L Bevan, Judith A Clements, Edward W Tate

 

Applications of liquid biopsy in the Pharmacological Audit Trail for anticancer drug development - Nat Rev Clin Oncol

2021 Jul;18(7):454-467.

Abhijit Pal, Rajiv Shinde, Manuel Selvi Miralles, Paul Workman, Johann de Bono

 

Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell CarcinomaCancers (Basel). 2021 Jul 30;13(15):3854. 

Saira Khalique, Sarah Nash, David Mansfield, Julian Wampfler, Ayoma Attygale, Katherine Vroobel, Harriet Kemp, Richard Buus, Hannah Cottom, Ioannis Roxanis, Thomas Jones, Katharina von Loga, Dipa Begum, Naomi Guppy, Pradeep Ramagiri, Kerry Fenwick, Nik Matthews, Michael J F Hubank, Christopher J Lord, Syed Haider, Alan Melcher, Susana Banerjee, Rachael Natrajan

 

Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatmentNat Cancer. 2021 Jul;2(7):680-692.

Nida Pasha & Nicholas C. Turner

 

Detecting hypoxia in vitro using 18F-pretargeted IEDDA "click" chemistry in live cellsRSC Adv. 2021 Jun 7;11(33):20335-20341.

Louis Allott, Cen Chen, Marta Braga, Sau Fung Jacob Leung, Ning Wang, Chris Barnes, Diana Brickute, Laurence Carroll, Eric O Aboagye.

 

Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinomaJ Clin Invest. 2021 Jun 1;131(11):e137845. 

Daria Capece, Daniel D'Andrea, Federica Begalli, Laura Goracci, Laura Tornatore, James L Alexander, Alessandra Di Veroli, Shi-Chi Leow, Thamil S Vaiyapuri, James K Ellis, Daniela Verzella, Jason Bennett, Luca Savino, Yue Ma, James S McKenzie, Maria Luisa Doria, Sam E Mason, Kern Rei Chng, Hector C Keun, Gary Frost, Vinay Tergaonkar, Katarzyna Broniowska, Walter Stunkel, Zoltan Takats, James M Kinross, Gabriele Cruciani, Guido Franzoso

 

An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the RectumDis Colon Rectum. 2021 Jun 1;64(6):677-688.

Ian S Reynolds, Emer O'Connell, Michael Fichtner, Anna Blümel, Sam E Mason, James Kinross, Deborah A McNamara, Elaine W Kay, Darran P O'Connor, Sudipto Das, John P Burke, Jochen H M Prehn

 

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547.

Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew J Fuchter, Anthony I Magee, Christian Siebold, Edward W Tate

 

Zinc stable isotopes in urine as diagnostic for cancer of secretory organsMetallomics. 2021 May 12;13(5):mfab020.

Kathrin Schilling, Rebekah E T Moore, Kaj V Sullivan, Miles S Capper, Mark Rehkämper, Kate Goddard, Charlotte Ion, R Charles Coombes, Lois Vesty-Edwards, Alastair D Lamb, Alex N Halliday, Fiona Larner

 

Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissueMetallomics. 2021 May 31;13(6):mfab027.

Kaj V Sullivan, Rebekah E T Moore, Miles S Capper, Kathrin Schilling, Kate Goddard, Charlotte Ion, Daniel Layton-Matthews, Matthew I Leybourne, Barry Coles, Katharina Kreissig, Olga Antsygina, R Charles Coombes, Fiona Larner, Mark Rehkämper

 

The association between obesity and weight loss after bariatric surgery on the vaginal microbiota Microbiome. 2021 May 28;9(1):124. 

Olivia Raglan, David A. MacIntyre, Anita Mitra, Yun S. Lee, Ann Smith, Nada Assi, Jaya Nautiyal, Sanjay Purkayastha, Marc J. Gunter, Hani Gabra, Julian R. Marchesi, Phillip R. Bennett & Maria Kyrgiou

 

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 - Nature Communications 2021 Apr 6;12(1):2043.

Omar M Khan, Jorge Almagro, Jessica K Nelson, Stuart Horswell, Vesela Encheva, Kripa S Keyan, Bruce E Clurman, Ambrosius P Snijders, Axel Behrens

 

HER3 expression and MEK activation in non-small-cell lung carcinomaLung Cancer Manag 2021 Apr 9;10(2):LMT48.

Thubeena Manickavasagar, Wei Yuan, Suzanne Carreira, Bora Gurel, Susana Miranda, Ana Ferreira, Mateus Crespo, Ruth Riisnaes, Chloe Baker, Mary O'Brien, Jaishree Bhosle, Sanjay Popat, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom 

 

Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapyJ Immunother Cancer. 2021 Apr;9(4):e002421.

Alessio Cortellini, Massimo Di Maio, Olga Nigro, Alessandro Leonetti, Diego L Cortinovis, Joachim GJV Aerts, Giorgia Guaitoli, Fausto Barbieri, Raffaele Giusti, Miriam G Ferrara,, Emilio Bria,, Ettore D'Argento, Francesco Grossi, Erika Rijavec, Annalisa Guida, Rossana Berardi, Mariangela Torniai, Vincenzo Sforza, Carlo Genova, Francesca Mazzoni, Marina Chiara Garassino, Alessandro De Toma, Diego Signorelli,, Alain Gelibter, Marco Siringo, Paolo Marchetti, Marianna Macerelli, Francesca Rastelli, Rita Chiari, Danilo Rocco, Luigi Della Gravara, Alessandro Inno, De Tursi Michele, Antonino Grassadonia, Pietro Di Marino, Giovanni Mansueto, Federica Zoratto, Marco Filetti, Daniele Santini, Fabrizio Citarella, Marco Russano, Luca Cantini,, Alessandro Tuzi, Paola Bordi, Gabriele Minuti, Lorenza Landi, Serena Ricciardi, Maria R Migliorino, Francesco Passiglia, Paolo Bironzo, Giulio Metro, Vincenzo Adamo, Alessandro Russo, Gian Paolo Spinelli, Giuseppe L Banna, Alex Friedlaender, Alfredo Addeo, Katia Cannita, Corrado Ficorella,, Giampiero Porzio, and David J Pinato

 

Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy - BioRxiv 2021.03.05.431171.

J. Lightley, F. Görlitz, S. Kumar, R. Kalita, A. Kolbeinsson, E. Garcia, Y Alexandrov, V. Bousgouni, R. Wysoczanski, P. Barnes, L. Donnelly, C. BakalC. Dunsby, M.A.A. Neil, S. Flaxman, P.M.W. French

 

Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cellsBioRxiv 2021.04.21.440779

Dalia Rosano, Emre Sofyali, Heena Dhiman, Diana Ivanoiu, Neil Slaven, Sung Pil Hong, Andrea Rocca, Sara Bravaccini, Sara Ravaioli, Roberta Noberini, Tiziana Bonaldi, Luca Magnani

 

Validation of Ultrasonic Harmonic Scalpel for Real-Time Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry - Anal Chem 2021 Apr 13;93(14):5906-5916.

Eftychios Manoli, Sam Mason, Lauren Ford, Afeez Adebesin, Zsolt Bodai, Ara DarziJames KinrossZoltan Takats

 

FOXA1 is a determinant of drug resistance in breast cancer cellsBreast Cancer Res Treat. 2021 Apr;186(2):317-326.

Uttom Kumar, Anastasia Ardasheva, Zimam Mahmud, R. Charles Coombes & Ernesto Yagüe

 

Radiolabelling an 18F biologic via facile IEDDA "click" chemistry on the GE FASTLab™ platform React Chem Eng. 2021 Apr 15;6(6):1070-1078.

Louis Allott, Ala Amgheib, Chris Barnes, Marta Braga, Diana Brickute, Ning Wang, Ruisi Fu, Sadaf Ghaem-Maghami, Eric O Aboagye

 

Phenotypic Characteristics of the Tumour Microenvironment in Primary and Secondary Hepatocellular CarcinomaCancers (Basel). 2021 Apr 29;13(9):2137.

Petros Fessas, Paolo Spina, Renzo L Boldorini, Mario Pirisi, Rosalba Minisini, Francesco A Mauri, Fraser Simpson, Paola Olivieri, Alessandra Gennari, Ching Ngar Wong, Abdul Siddique, Robert D Goldin, Ayse U Akarca, Teresa Marafioti, David J Pinato

 

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs - Proc Natl Acad Sci U S A 2021 Apr 27;118(17):e2018229118.

Paula Saavedra-García, Monica Roman-Trufero, Hibah A Al-Sadah, Kevin Blighe, Elena López-Jiménez, Marilena Christoforou, Lucy Penfold, Daria Capece, Xiaobei Xiong, Yirun Miao, Katarzyna Parzych, Valentina S Caputo, Alexandros P Siskos, Vesela Encheva, Zijing Liu, Denise Thiel, Martin F Kaiser, Paolo Piazza, Aristeidis Chaidos, Anastasios Karadimitris, Guido Franzoso, Ambrosius P Snijders, Hector C KeunDiego A OyarzúnMauricio Barahona, Holger W Auner


Public resources for chemical probes: the journey so far and the road ahead - Future Med Chem 2021 Apr;13(8):731-747.

Albert A Antolin, Paul Workman, Bissan Al-Lazikani

 

Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays - BMJ Open

2021 Mar 19;11(3):e047163.

Patrick Kierkegaard, Anna McLister, Peter Buckle

 

Estimating the Risk of Death from COVID-19 in Adult Cancer Patients - Clin Oncol (R Coll Radiol) 2021 Mar;33(3):e172-e179.

M Williams, E Mi, K Le Calvez, J Chen, L Pakzad-Shahabi, S Dadhania, J Wang, A Ho, S Rabinowicz

 

PRIME-HCC: phase Ib study of neoadjuvant ipilimumab and nivolumab prior to liver resection for hepatocellular carcinomaBMC Cancer. 2021 Mar 23;21(1):301. 

David J. Pinato, Alessio Cortellini, Ajithkumar Sukumaran, Tom Cole, Madhava Pai, Nagy Habib, Duncan Spalding, Mikael H. Sodergren, Maria Martinez, Tony Dhillon, Paul Tait, Robert Thomas, Caroline Ward, Hemant Kocher, Vincent Yip, Sarah Slater & Rohini Sharma 

 

Deconvoluting the biology and druggability of protein lipidation using chemical proteomics - Curr Opin Chem Biol 2021 Feb;60:97-112.

Ana Losada de la Lastra, Sarah Hassan, Edward W Tate

 

Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κBOncogene. 2021 Feb;40(6):1077-1090.

Manikandan Periyasamy, Anup K. Singh, Carolina Gemma, Raed Farzan, Rebecca C. Allsopp, Jacqueline A. Shaw, Sara Charmsaz, Leonie S. Young, Paula Cunnea, R. Charles Coombes, Balázs Győrffy, Lakjaya Buluwela & Simak Ali

    

Determinants of physician networks: an ethnographic study examining the processes that inform patterns of collaboration and referral decision-making among physicians - BMJ Open 2021 Jan 5;11(1):e042334.

Patrick Kierkegaard, Jason Owen-Smith


Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis - Br J Cancer 2021 Jan;124(1):58-65.

Julia Perea Paizal, Sam H AuChris Bakal

 

Qualification of tumour mutational burden by targeted next-generation sequencing as a biomarker in hepatocellular carcinomaLiver Int. 2021 Jan;41(1):192-203.

Ching Ngar Wong, Petros Fessas, Kathy Dominy, Francesco A. Mauri, Takahiro Kaneko, Persephone Du Parcq, Jamshid Khorashad, Pierluigi Toniutto, Robert D. Goldin, Claudio Avellini, David J. Pinato

 

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH - Nat Protoc 2021 Jan;16(1):239-262.

Hendrik A Messal, Jorge Almagro, May Zaw Thin, Antonio Tedeschi, Alessandro Ciccarelli, Laura Blackie, Kurt I Anderson, Irene Miguel-Aliaga, Jacco van Rheenen, Axel Behrens


Opportunities at the Interface of Network Science and Metabolic Modeling - Front Bioeng Biotechnol 2021 Jan 25;8:591049.

Varshit Dusad, Denise ThielMauricio BarahonaHector C KeunDiego A Oyarzún

2020

Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease - BMC Cancer 2020 Dec 9;20(1):1210.

Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E O'Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom

 

Organoid models in gynaecological oncology researchCancer Treat Rev. 2020 Nov;90:102103.

Anita Semertzidou, Jan J. Brosens, Iain McNeish, Maria Kyrgiou

 

Laser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screeningEBioMedicine. 2020 Oct;60:103017.

Maria Paraskevaidi, Simon J.S. Cameron, Eilbhe Whelan, Sarah Bowden, Menelaos Tzafetas, Anita Mitra, Anita Semertzidou, Antonis Athanasiou, Phillip R. Bennett, David A. MacIntyre, Zoltan TakatsMaria Kyrgiou 

 

Evolution of kinase polypharmacology across HSP90 drug discovery - BioRxiv 2020.09.09.288936.

Albert A. Antolin, Paul A. Clarke, Ian Collins, Paul Workman, Bissan Al-Lazikani

 

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches - Sci Rep 2020 Sep 29;10(1):16000.

John F Darby, Lewis R Vidler, Peter J Simpson, Bissan Al-Lazikani, Stephen J Matthews, Swee Y Sharp, Laurence H Pearl, Swen Hoelder, Paul Workman

 

Cancer Loyalty Card Study (CLOCS): protocol for an observational case–control study focusing on the patient interval in ovarian cancer diagnosisBMJ Open2020 Sep 8;10(9):e037459. 

Hannah R Brewer, Yasemin Hirst, Sudha Sundar, Marc Chadeau-Hyam, James M Flanagan

 

β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells - Metabolites Aug 26;10(9):346.

Adrian Benito, Nabil Hajji, Kevin O’Neill, Hector C. Keun, Nelofer Syed

 

Disentangling the Relationship between Physician and Organizational Performance: A Signal Detection ApproachMed Decis Making. 2020 Aug;40(6):746-755.

Olga Kostopoulou, Martine Nurek, Brendan C Delaney

 

Tracking and visualization of the sensing area for a tethered laparoscopic gamma probe - Int J Comput Assist Radiol Surg. 2020 Aug;15(8):1389-1397. 

Baoru Huang, Ya-Yen Tsai, João Cartucho, Kunal Vyas, David Tuch, Stamatia Giannarou & Daniel S. Elson 

 

Rhenium-Based Complexes and in Vivo Testing: A Brief HistoryChembiochem. 2020 Aug 3;21(15):2111-2115

Miles S. Capper, Hollie Packman, Mark Rehkämper

 

Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international studyJ Immunother Cancer. 2020 Aug;8(2):e001033.

Petros Fessas, Ahmed Kaseb, Yinghong Wang, Anwaar Saeed, David Szafron, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh Naqash, Mahvish Muzaffar, Musharraf Navaid, Uqba Khan, ChiehJu Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar Dominik Bettinger, Francesca Benevento, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Yi-Hsiang Huang, Lorenza Rimassa, Celina Ang, Thomas Marron, David J Pinato

 

Mass spectrometry transanal minimally invasive surgery (MS-TAMIS) to promote organ preservation in rectal cancer - Surg Endosc 2020 Aug;34(8):3618-3625.

Sam Mason, Eftychios Manoli, Liam Poynter, James Alexander, Petra Paizs, Afeez Adebesin, Robert Goldin, Ara DarziZoltan TakatsJames Kinross

 

Presenting Features and Early Mortality from SARS-CoV-2 Infection in Cancer Patients during the Initial Stage of the COVID-19 Pandemic in EuropeCancers (Basel). 2020 Jul 8;12(7):1841. 

David J Pinato, Alvin J X Lee, Federica Biello, Elia Seguí, Juan Aguilar-Company, Anna Carbó, Riccardo Bruna, Mark Bower, Gianpiero Rizzo, Sarah Benafif, Carme Carmona, Neha Chopra, Claudia Andrea Cruz, Francesca D'Avanzo, Joanne S Evans, Myria Galazi, Isabel Garcia-Fructuoso, Alessia Dalla Pria, Thomas Newsom-Davis, Diego Ottaviani, Andrea Patriarca, Roxana Reyes, Rachel Sharkey, Christopher C T Sng, Yien Ning Sophia Wong, Daniela Ferrante, Lorenza Scotti, Gian Carlo Avanzi, Mattia Bellan, Luigi Mario Castello, Javier Marco-Hernández, Meritxell Mollà, Mario Pirisi, Isabel Ruiz-Camps, Pier Paolo Sainaghi, Gianluca Gaidano, Joan Brunet, Josep Tabernero, Aleix Prat, Alessandra Gennari

 

Clinical portrait of the SARS-CoV-2 epidemic in European cancer patientsCancer Discov. 2020 Jul 31;10(10):1465-1474.

David J. Pinato; Alberto Zambelli; Juan Aguilar-Company; Mark Bower ; Christopher C.T. Sng ; Ramon Salazar; Alexia Bertuzzi; Joan Brunet ; Ricard Mesia; Elia Seguí; Federica Biello; Daniele Generali; Salvatore Grisanti; Gianpiero Rizzo; Michela Libertini; Antonio Maconi; Nadia Harbeck; Bruno Vincenzi; Rossella Bertulli; Diego Ottaviani; Anna Carbó; Riccardo Bruna; Sarah Benafif; Andrea Marrari; Rachel Wuerstlein; M. Carmen Carmona-Garcia ; Neha Chopra; Carlo Tondini ; Oriol Mirallas ; Valeria Tovazzi; Marta Betti; Salvatore Provenzano; Vittoria Fotia; Claudia Andrea Cruz; Alessia Dalla Pria; Francesca D'Avanzo; Joanne S. Evans; Nadia Saoudi-Gonzalez; Eudald Felip; Myria Galazi ; Isabel Garcia-Fructuoso; Alvin J.X. Lee; Thomas Newsom-Davis; Andrea Patriarca; David García-Illescas; Roxana Reyes; Palma Dileo; Rachel Sharkey; Yien Ning Sophia Wong; Daniela Ferrante; Javier Marco-Hernández; Anna Sureda; Clara Maluquer; Isabel Ruiz-Camps; Gianluca Gaidano; Lorenza Rimassa; Lorenzo Chiudinelli; Macarena Izuzquiza; Alba Cabirta; Michela Franchi; Armando Santoro; Aleix Prat; Josep Tabernero; Alessandra Gennari; Gian Carlo Avanzi; Mattia Bellan; Luigi Mario Castello; Maria Martinez; Meritxell Mollà; Mario Pirisi; Lorenza Scotti; Judith Swallow

 

Immunotherapy in Hepatocellular Cancer Patients with Mild to Severe Liver Dysfunction: Adjunctive Role of the ALBI GradeCancers (Basel). 2020 Jul 10;12(7):1862.

David J Pinato, Takahiro Kaneko, Anwaar Saeed, Tiziana Pressiani, Ahmed Kaseb, Yinghong Wang, David Szafron, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh Naqash, Mahvish Muzaffar, Musharraf Navaid, Chieh-Ju Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I Abugabal, Celina Ang, Thomas U Marron, Uqba Khan, Nicola Personeni, Lorenza Rimassa, Yi-Hsiang Huang

 

Next-generation robotics in gastrointestinal surgeryNat Rev Gastroenterol Hepatol. 2020 Jul;17(7):430-440.

James M. Kinross, Sam E. Mason, George Mylonas & Ara Darzi 

 

Remote shared care delivery: a virtual response to COVID-19Lancet Digit Health. 2020 Jun;2(6):e288-e289. 

Kamalini Ramdas, Faheem Ahmed, Ara Darzi

 

Development of a fluorine-18 radiolabelled fluorescent chalcone: evaluated for detecting glycogenEJNMMI Radiopharm Chem. 2020 Jun 23;5(1):17. 

Louis Allott, Diana Brickute, Cen Chen, Marta Braga, Chris Barnes, Ning Wang, Eric O Aboagye

 

Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965Cancers (Basel). 2020 Jun 26;12(6):1703. 

Marta Braga, Maciej Kaliszczak, Laurence Carroll, Zachary T Schug, Kathrin Heinzmann, Nicoleta Baxan, Adrian Benito, Gabriel N Valbuena, Stephen Stribbling, Alice Beckley, Gillian Mackay, Francesco Mauri, John Latigo, Chris Barnes, Hector Keun, Eyal Gottlieb, Eric O Aboagye

 

Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cellsBr J Cancer. 2020 Apr;122(9):1298-1308.

Emily M. E. Barnes, Yitao Xu, Adrian Benito, Lili Herendi, Alexandros P. Siskos, Eric O. Aboagye, Anke Nijhuis & Hector C. Keun

 

Proteomic analysis of malignant and benign endometrium according to obesity and insulin-resistance status using Reverse Phase Protein ArrayTransl Res. 2020 Apr;218:57-72.

Olivia Raglan, Nada Assi, Jaya Nautiyal, Haonan Lu, Hani Gabra, Marc J Gunter, Maria Kyrgiou

 

Is it time to nationalise the pharmaceutical industry? - BMJ 2020 Mar 4;368:m769.

Mariana Mazzucato, Henry Lishi Li, Ara Darzi

 

David J Pinato, Heather Urus, Thomas Newsom-Davis, Persephone Du Parcq, Katherine Belessiotis, Leah Mapara, Nandita Gupta, Danielle Power, Justin Weir, Ching Ngar Wong, Ragu P Ratnakumaran, Kathy Dominy, Jamshid Khorashad, Mark Bower

 

The kinase polypharmacology landscape of clinical PARP inhibitors - Sci Rep 2020 Feb 17;10(1):2585.

Albert A Antolin, Malaka Ameratunga, Udai Banerji, Paul A Clarke, Paul Workman, Bissan Al-Lazikani

 

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942Oncogene. 2020 Jan;39(3):651-663.

Georgina P. Sava, Hailing Fan, Rosemary A. Fisher, Sabrina Lusvarghi, Sunil Pancholi, Suresh V. Ambudkar, Lesley-Ann Martin, R. Charles Coombes, Lakjaya Buluwela & Simak Ali

 

Ovarian-Adnexal Reporting Data System Magnetic Resonance Imaging (O-RADS MRI) Score for Risk Stratification of Sonographically Indeterminate Adnexal MassesJAMA Netw Open. 2020 Jan 3;3(1):e1919896.

Isabelle Thomassin-Naggara, Edouard Poncelet, Aurelie Jalaguier-Coudray, Adalgisa Guerra, Laure S Fournier, Sanja Stojanovic, Ingrid Millet, Nishat Bharwani, Valerie Juhan, Teresa M Cunha, Gabriele Masselli, Corinne Balleyguier, Caroline Malhaire, Nicolas F Perrot, Elizabeth A Sadowski, Marc Bazot, Patrice Taourel, Raphaël Porcher, Emile Darai, Caroline Reinhold, Andrea G Rockall

 

International evaluation of an AI system for breast cancer screeningNature. 2020 Jan;577(7788):89-94.

Scott Mayer McKinney, Marcin Sieniek, Varun Godbole, Jonathan Godwin, Natasha Antropova, Hutan Ashrafian, Trevor Back, Mary Chesus, Greg S. Corrado, Ara Darzi, Mozziyar Etemadi, Florencia Garcia-Vicente, Fiona J. Gilbert, Mark Halling-Brown, Demis Hassabis, Sunny Jansen, Alan Karthikesalingam, Christopher J. Kelly, Dominic King, Joseph R. Ledsam, David Melnick, Hormuz Mostofi, Lily Peng, Joshua Jay Reicher, Bernardino Romera-Paredes, Richard Sidebottom, Mustafa Suleyman, Daniel Tse, Kenneth C. Young, Jeffrey De Fauw & Shravya Shetty

 

 

2019

Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α Cancers (Basel). 2019 Dec 7;11(12):1969.

Matthew Grech-Sollars, Katherine L Ordidge, Babar Vaqas, Claire Davies, Vijay Vaja, Lesley Honeyfield, Sophie Camp, David Towey, Helen Mayers, David Peterson, Kevin O'Neill, Federico Roncaroli, Tara D Barwick, Adam D Waldman

 

FSP1 is a glutathione-independent ferroptosis suppressor - Nature 2019 Nov;575(7784):693-698.

Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina H Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O'Donnell, Bettina Proneth, Grzegorz M Popowicz, Derek A Pratt, José Pedro Friedmann Angeli, Marcus Conrad

 

The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencingSci Rep. 2019 Oct 31;9(1):15787.

Gabriel N. Valbuena, Sophia Apostolidou, Rhiannon Roberts, Julie Barnes, Wendy Alderton, Lauren Harper, Ian Jacobs, Usha Menon & Hector C. Keun

 

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapyNat Commun. 2019 Sep 2;10(1):3840.

Sung Pil Hong, Thalia E. Chan, Ylenia Lombardo, Giacomo Corleone, Nicole Rotmensz, Sara Bravaccini, Andrea Rocca, Giancarlo Pruneri, Kirsten R. McEwen, R. Charles Coombes, Iros Barozzi & Luca Magnani

 

Optical Technologies for Endoscopic Real-Time Histologic Assessment of Colorectal Polyps: A Meta-Analysis - Am J Gastroenterol 2019 Aug;114(8):1219-1230.

Sam E Mason, Liam Poynter, Zoltan TakatsAra DarziJames M Kinross

 

Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic RecurrenceClin Cancer Res. 2019 Jul 15;25(14):4255-4263.

Raoul Charles Coombes; Karen Page; Raheleh Salari; Robert K. Hastings ; Anne Armstrong ; Samreen Ahmed; Simak Ali; Susan Cleator; Laura Kenny; Justin Stebbing; Mark Rutherford ; Himanshu Sethi; Anna Boydell; Ryan Swenerton; Daniel Fernandez-Garcia; Kelly L.T. Gleason; Katie Goddard; David S. Guttery; Zoe J. Assaf; Hsin-Ta Wu; Prashanthi Natarajan; David A. Moore; Lindsay Primrose; Scott Dashner; Antony S. Tin; Mustafa Balcioglu; Ramya Srinivasan; Svetlana V. Shchegrova; Alexander Olson; Dina Hafez; Paul Billings; Alexey Aleshin; Farah Rehman; Bradley J. Toghill; Allison Hills; Maggie C. Louie; Cheng-Ho Jimmy Lin; Bernhard G. Zimmermann; Jaqueline A. Shaw

 

Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancerOncogene. 2019 Jul;38(28):5700-5724. 

Claire E. Fletcher, Eric Sulpice, Stephanie Combe, Akifumi Shibakawa, Damien A. Leach, Mark P. Hamilton, Stelios L. Chrysostomou, Adam Sharp, Jon Welti, Wei Yuan, Dafydd. A. Dart, Eleanor Knight, Jian Ning, Jeffrey C. Francis, Evangelia E. Kounatidou, Luke Gaughan, Amanda Swain, Shawn E. Lupold, Johann S. de Bono, Sean E. McGuire, Xavier Gidrol & Charlotte L. Bevan

 

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases - Cell Chem Biol  2019 Jun 20;26(6):892-900.e4.

Wouter W Kallemeijn, Gregor A Lueg, Monica Faronato, Kate Hadavizadeh, Andrea Goya Grocin, Ok-Ryul Song, Michael Howell, Dinis P Calado, Edward W Tate

 

Novel real-time optical imaging modalities for the detection of neoplastic lesions in urology: a systematic reviewSurg Endosc. 2019 May;33(5):1349-1367.

Oliver Brunckhorst, Qi Jia Ong, Daniel Elson & Erik Mayer

 

Development of 68Ga-labelled ultrasound microbubbles for whole-body PET imagingChem Sci. 2019 May 1;10(21):5603-5615.

Javier Hernández-Gil, Marta Braga, Bethany I Harriss, Laurence S Carroll, Chee Hau Leow, Meng-Xing Tang, Eric O Aboagye, Nicholas J Long

 

3-D Microvascular Imaging Using High Frame Rate Ultrasound and ASAP Without Contrast Agents: Development and Initial In Vivo Evaluation on Nontumor and Tumor ModelsIEEE Trans Ultrason Ferroelectr Freq Control. 2019 May;66(5):939-948.

Chee Hau Leow, Nigel L Bush, Antonio Stanziola, Marta Braga, Anant Shah, Javier Hernandez-Gil, Nicholas J Long, Eric O Aboagye, Jeffrey C Bamber, Meng-Xing Tang

 

Clinical implications of heterogeneity in PD-L1 immunohistochemical detection in hepatocellular carcinoma: the Blueprint-HCC studyBr J Cancer. 2019 May;120(11):1033-1036. 

David J. Pinato, Francesco A. Mauri, Paolo Spina, Owen Cain, Abdul Siddique, Robert Goldin, Stephane Victor, Corinna Pizio, Ayse U. Akarca, Renzo L. Boldorini, Luca Mazzucchelli, James R. M. Black, Shishir Shetty, Teresa Marafioti & Rohini Sharma

 

Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 ExpressionMol Pharm. 2019 May 6;16(5):2106-2117. 

Diana Brickute, Marta Braga, Maciej A Kaliszczak, Chris Barnes, Doreen Lau, Laurence Carroll, Elizabeth Stevens, Sebastian Trousil, Israt S Alam, Quang-Dé Nguyen, Eric O Aboagye

 

Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases Biochem Pharmacol. 2019 May;163:391-403.

Zimam Mahmud, Muhammad Asaduzzaman, Uttom Kumar, Nahal Masrour, Roman Jugov, R Charles Coombes, Sami Shousha, Yunhui Hu, Eric W-F Lam, Ernesto Yagüe

 

SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancerNat Commun. 2019 May 9;10(1):2115. 

Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez-Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charles Coombes, Giancarlo Pruneri, Adrian Lim, Fernando Calvo & Luca Magnani

 

Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer riskClin Epigenetics. 2019 Apr 30;11(1):66.

Annelie Johansson, Domenico Palli, Giovanna Masala, Sara Grioni, Claudia Agnoli, Rosario Tumino, Maria Concetta Giurdanella, Francesca Fasanelli, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Silvia Polidoro, Michael E. Jones, Minouk J. Schoemaker, Nick Orr, Katarzyna Tomczyk, Nichola Johnson, Olivia Fletcher, Vittorio Perduca, Laura Baglietto, Pierre-Antoine Dugué, Melissa C. Southey, Graham G. Giles, Dallas R. English, Roger L. Milne, Gianluca Severi, Srikant Ambatipudi, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Zdenko Herceg, Anthony J. Swerdlow, Paolo Vineis & James M. Flanagan

 

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3Toxicol Rep. 2019 Apr 19;6:369-379.

Laura Tornatore, Daria Capece, Daniel D'Andrea, Federica Begalli, Daniela Verzella, Jason Bennett, Gary Acton, Elizabeth A Campbell, James Kelly, Michael Tarbit, Nigel Adams, Selina Bannoo, Antonio Leonardi, Annamaria Sandomenico, Domenico Raimondo, Menotti Ruvo, Angela Chambery, Metod Oblak, Magda J Al-Obaidi, Richard S Kaczmarski, Ian Gabriel, Heather E Oakervee, Martin F Kaiser, Ashutosh Wechalekar, Reuben Benjamin, Jane F Apperley, Holger W Auner, Guido Franzoso

 

Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma Br J Cancer. 2019 Mar;120(5):512-521.

David J. Pinato, Matthew W. Brown, Sebastian Trousil, Eric O. Aboagye, Jamie Beaumont, Hua Zhang, Helen M. Coley, Francesco A. Mauri & Rohini Sharma

 

Evaluation of apoptosis imaging biomarkers in a genetic model of cell deathEJNMMI Res. 2019 Feb 19;9(1):18.

Vessela Vassileva, Stephen M Stribbling, Chris Barnes, Laurence Carroll, Marta Braga, Joel Abrahams, Kathrin Heinzmann, Caroline Haegeman, Marion MacFarlane, Kathryn L Simpson, Caroline Dive, Jamie Honeychurch, Timothy M Illidge, Eric O Aboagye

 

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A - Mol Cell Proteomics 2019 Jan;18(1):115-126.

Andrea Goya Grocin, Remigiusz A Serwa, Julia Morales Sanfrutos, Markus Ritzefeld, Edward W Tate

 

Referral Decision Making of General Practitioners: A Signal Detection StudyMed Decis Making. 2019 Jan;39(1):21-31.

Olga Kostopoulou, Martine Nurek, Simona Cantarella, Grace Okoli, Francesca Fiorentino, Brendan C Delaney

 

Self-Care Behaviors of Ovarian Cancer Patients Before Their Diagnosis: Proof-of-Concept StudyJMIR Cancer. 2019 Jan 17;5(1):e10447.

James M Flanagan, Hanna Skrobanski, Xin Shi, Yasemin Hirst

 

2018

An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical propertiesBiomaterials. 2018 Nov;183:102-113.

Sandra Loaiza, Silvia A Ferreira, Tamara M Chinn, Alex Kirby, Elena Tsolaki, Camilla Dondi, Katarzyna Parzych, Adam P Strange, Laurent Bozec, Sergio Bertazzo, Martin A B Hedegaard, Eileen Gentleman, Holger W Auner

 

Is symptom-based diagnosis of lung cancer possible? A systematic review and meta-analysis of symptomatic lung cancer prior to diagnosis for comparison with real-time data from routine general practicePLoS One. 2018 Nov 21;13(11):e0207686.

Grace N. Okoli, Olga Kostopoulou, Brendan C. Delaney

 

An improved rapid sampling microdialysis system for human and porcine organ monitoring in a hospital settingAnal Methods. 2018 Nov 28;10(44):5273-5281.

Sally A N Gowers, Karim Hamaoui, Natalie Vallant, George B Hanna, Ara Darzi, Daniel Casanova, Vassilios Papalois, Martyn G Boutelle

 

Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancerNat Med. 2018 Sep;24(9):1469-1480

Darren K. Patten, Giacomo Corleone, Balázs Győrffy, Ylenia Perone, Neil Slaven, Iros Barozzi, Edina Erdős, Alina Saiakhova, Kate Goddard, Andrea Vingiani, Sami Shousha, Lőrinc Sándor Pongor, Dimitri J. Hadjiminas, Gaia Schiavon, Peter Barry, Carlo Palmieri, Raul C. Coombes, Peter Scacheri, Giancarlo Pruneri & Luca Magnani

 

The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancerEMBO Rep. 2018 Aug;19(8):e45670. 

Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi

 

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1Oncogene. 2018 Sep;37(39):5305-5324.

Zainab Al Shareef, Hoda Kardooni, Virginia Murillo-Garzón, Giacomo Domenici, Emmanouil Stylianakis, Jennifer H. Steel, Miriam Rabano, Irantzu Gorroño-Etxebarria, Ignacio Zabalza, Maria dM Vivanco, Jonathan Waxman & Robert M. Kypta

 

Dual-modality endoscopic probe for tissue surface shape reconstruction and hyperspectral imaging enabled by deep neural networksMed Image Anal. 2018 Aug;48:162-176. 

Jianyu Lin, Neil T Clancy, Ji Qi, Yang Hu, Taran Tatla, Danail Stoyanov, Lena Maier-Hein, Daniel S Elson 

 

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer TreatmentMol Cancer Ther. 2018 Jun;17(6):1156-1166.

Hetal Patel; Manikandan Periyasamy; Georgina P. Sava; Alexander Bondke; Brian W. Slafer; Sebastian H. B. Kroll; Marion Barbazanges; Richard Starkey; Silvia Ottaviani; Alison Harrod; Eric O. Aboagye; Laki Buluwela; Matthew J. Fuchter; Anthony G. M. Barrett; R. Charles Coombes; Simak Ali

 

CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer Cancers (Basel). 2018 May 28;10(6):165.

Hoda Kardooni, Estela Gonzalez-Gualda, Emmanouil Stylianakis, Sina Saffaran, Jonathan Waxman, Robert M Kypta

 

David L Phelps, Júlia Balog, Louise F Gildea, Zsolt Bodai, Adele Savage, Mona A El-Bahrawy, Abigail Vm Speller, Francesca Rosini, Hiromi Kudo, James S McKenzie, Robert Brown, Zoltán Takáts, Sadaf Ghaem-Maghami

 

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer Nat Commun. 2018 May 1;9(1):1747.

Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman & Robert M. Kypta

 

David L Phelps, Júlia Balog, Louise F Gildea, Zsolt Bodai, Adele Savage, Mona A El-Bahrawy, Abigail VM Speller, Francesca Rosini, Hiromi Kudo, James S McKenzie, Robert Brown, Zoltán Takáts & Sadaf Ghaem-Maghami

 

 

Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells Hepatology. 2019 Feb;69(2):785-802.

Ernesto Cortes, Dariusz Lachowski, Alistair Rice, Antonios Chronopoulos, Benjamin Robinson, Stephen Thorpe, David A Lee, Lucia A Possamai, Haiyun Wang, David J Pinato, Armando E. del Río Hernández

 

High temporal resolution delayed analysis of clinical microdialysate streamsAnalyst. 2018 Jan 29;143(3):715-724.

S A N Gowers, K Hamaoui, P Cunnea, S Anastasova, V F Curto, P Vadgama, G-Z Yang, V Papalois, E M Drakakis, C Fotopoulou, S G Weber, M G Boutelle

 

2017

IPET study: an FLT-PET window study to assess the activity of the steroid sulfatase inhibitor irosustat in early breast cancerBreast Cancer Res Treat. 2017 Nov;166(2):527-539.

Carlo Palmieri, Richard Szydlo, Marie Miller, Laura Barker, Neva H. Patel, Hironobu Sasano, Tara Barwick, Henry Tam, Dimitri Hadjiminas, Jasmin Lee, Abeer Shaaban, Hanna Nicholas, R. Charles Coombes & Laura M. Kenny 

 

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance Nat Commun. 2017 Nov 30;8(1):1865. 

Lesley-Ann Martin, Ricardo Ribas, Nikiana Simigdala, Eugene Schuster, Sunil Pancholi, Tencho Tenev, Pascal Gellert, Laki Buluwela, Alison Harrod, Allan Thornhill, Joanna Nikitorowicz-Buniak, Amandeep Bhamra, Marc-Olivier Turgeon, George Poulogiannis, Qiong Gao, Vera Martins, Margaret Hills, Isaac Garcia-Murillas, Charlotte Fribbens, Neill Patani, Zheqi Li, Matthew J Sikora, Nicholas Turner, Wilbert Zwart, Steffi Oesterreich, Jason Carroll, Simak Ali, Mitch Dowsett

 

Multibranched Gold Nanoparticles with Intrinsic LAT-1 Targeting Capabilities for Selective Photothermal Therapy of Breast CancerACS Appl Mater Interfaces. 2017 Nov 15;9(45):39259-39270. 

Zhan Yuin Ong, Shu Chen, Elham Nabavi, Anna Regoutz, David J Payne, Daniel S Elson, David T Dexter, Iain E Dunlop, Alexandra E Porter

 

Postprogression survival in patients with glioblastoma treated with concurrent chemoradiotherapy: a routine care cohort studyCNS Oncol. 2017 Oct;6(4):307-313. 

Paulina Majewska, Stefanos Ioannidis, Muhammad Hasan Raza, Nikhil Tanna, Helen Bulbeck & Mathew Williams

 

Gold nanorod reshaping in vitro and in vivo using a continuous wave laserPLoS One. 2017 Oct 18;12(10):e0185990.

David Harris-Birtill, Mohan Singh, Yu Zhou, Anant Shah, Pakatip Ruenraroengsak, Maria Elena Gallina, George B. Hanna, Anthony E. G. Cass, Alexandra E. Porter, Jeffrey Bamber, Daniel S. Elson

 

IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patientsBreast Cancer Res Treat. 2017 Sep;165(2):343-353.

Carlo Palmieri, Rob C. Stein, Xinxue Liu, Emma Hudson, Hanna Nicholas, Hironobu Sasano, Fouzia Guestini, Chris Holcombe, Sophie Barrett, Laura Kenny, Sadie Reed, Adrian Lim, Larry Hayward, Sacha Howell & R. Charles Coombes On behalf of the IRIS trial participants

 

Clinical Use of Programmed Cell Death-1 and Its Ligand Expression as Discriminatory and Predictive Markers in Ovarian CancerClin Cancer Res. 2017 Jul 1;23(13):3453-3460.

Jayanta Chatterjee, Wei Dai, Nor Haslinda Abd Aziz, Pei Yun Teo, John Wahba, David L Phelps, Christian J Maine, Lynsey M Whilding, Roberto Dina, Giorgia Trevisan, Kirsty J Flower, Andrew J T George, Sadaf Ghaem-Maghami

 

WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress responseCell Death Dis. 2017 Jul 27;8(7):e2955.

Szymon Janczar, Jaya Nautiyal, Yi Xiao, Edward Curry, Mingjun Sun, Elisa Zanini, Adam JW Paige & Hani Gabra

 

Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre studyBr J Cancer. 2017 May 9;116(10):1287-1293.

David L Phelps, Jane V Borley, Kirsty J Flower, Roberto Dina, Silvia Darb-Esfahani, Ioana Braicu, Jalid Sehouli, Christina Fotopoulou, Charlotte S Wilhelm-Benartzi, Hani Gabra, Joseph Yazbek, Jayanta Chatterjee, Jacey Ip, Harun Khan, Marina-Therese Likos-Corbett, Robert Brown & Sadaf Ghaem-Maghami

 

Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre studyBr J Cancer. 2017 May 9;116(10):1287-1293.

David L Phelps, Jane V Borley, Kirsty J Flower, Roberto Dina, Silvia Darb-Esfahani, Ioana Braicu, Jalid Sehouli, Christina Fotopoulou, Charlotte S Wilhelm-Benartzi, Hani Gabra, Joseph Yazbek, Jayanta Chatterjee, Jacey Ip, Harun Khan, Marina-Therese Likos-Corbett, Robert Brown & Sadaf Ghaem-Maghami

 

Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancerOncogene. 2017 Apr 20;36(16):2286-2296.

A Harrod, J Fulton, V T M Nguyen, M Periyasamy, L Ramos-Garcia, C-F Lai, G Metodieva, A de Giorgio, R L Williams, D B Santos, P J Gomez, M-L Lin, M V Metodiev, J Stebbing, L Castellano, L Magnani, R C Coombes, L Buluwela & S Ali

 

Postoperative hypothermia and surgical site infection following peritoneal insufflation with warm, humidified carbon dioxide during laparoscopic colorectal surgery: a cohort study with cost-effectiveness analysisSurg Endosc. 2017 Apr;31(4):1923-1929. 

Sam E Mason, James M Kinross, Jane Hendricks, Thanjakumar H Arulampalam

 

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancerNat Genet. 2017 Mar;49(3):444-450. 

Luca Magnani, Gianmaria Frigè, Raffaella Maria Gadaleta, Giacomo Corleone, Sonia Fabris, Hermannus Kempe, Pernette J Verschure, Iros Barozzi, Valentina Vircillo, Sung-Pil Hong, Ylenia Perone, Massimo Saini, Andreas Trumpp, Giuseppe Viale, Antonino Neri, Simak Ali, Marco Angelo Colleoni, Giancarlo Pruneri & Saverio Minucci

 

Engineering innovative solutions to screen for prostate cancerConverg Sci Phys Oncol.
Dana Al Sulaiman, Gavin A D Metcalf and Sylvain Ladame

 

Review article: Novel technologies in the treatment and monitoring of advanced and relapsed epithelial ovarian cancerConverg Sci Phys Oncol. 2017;3:013002. 

Paula Cunnea, Sally Gowers, James E Moore Jr, Emmanuel Drakakis, Martyn Boutelle and Christina Fotopoulou

 

 

2016

Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imagingSci Rep. 2016 Dec 15:6:39219.

Maria Luisa Dória, James S. McKenzie, Anna Mroz, David L. Phelps, Abigail Speller, Francesca Rosini, Nicole Strittmatter, Ottmar Golf, Kirill Veselkov, Robert Brown, Sadaf Ghaem-Maghami & Zoltan Takats 

 

Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast CancerClin Cancer Res. 2016 Dec 1;22(23):5929-5938.

Hetal Patel; Rezvan Abduljabbar; Chun-Fui Lai; Manikandan Periyasamy; Alison Harrod; Carolina Gemma; Jennifer H. Steel; Naina Patel; Claudia Busonero; Dena Jerjees; Judit Remenyi; Sally Smith; Jennifer J. Gomm; Luca Magnani; Balázs Győrffy; Louise J. Jones; Frances Fuller-Pace; Sami Shousha; Laki Buluwela; Emad A. Rakha; Ian O. Ellis; R. Charles Coombes; Simak Ali

 

MicroRNAs associated with small bowel neuroendocrine tumours and their metastasesEndocr Relat Cancer. 2016 Sep;23(9):711-26. 

Helen C Miller, Adam E Frampton, Anna Malczewska, Silvia Ottaviani, Euan A Stronach, Rashpal Flora, Daniel Kaemmerer, Gert Schwach, Roswitha Pfragner, Omar Faiz, Beata Kos-Kudła, George B Hanna, Justin Stebbing, Leandro Castellano, and Andrea Frilling

 

Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer DiagnosisAnal Chem. 2016 Aug 16;88(16):8091-8.

Gavin A D Metcalf, Akifumi Shibakawa, Hinesh Patel, Ailsa Sita-Lumsden, Andrea Zivi, Nona Rama, Charlotte L Bevan, Sylvain Ladame

 

Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteasesCarcinogenesis. 2016 Jan;37(1):18-29.

Diana Romero, Zainab Al-Shareef, Irantzu Gorroño-Etxebarria, Stephanie Atkins, Frances Turrell, Jyoti Chhetri, Nora Bengoa-Vergniory, Christoph Zenzmaier, Peter Berger, Jonathan Waxman, Robert Kypta

 

 

2015

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast CancerCell Rep. 2015 Oct 6;13(1):108-121.

Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T M Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S Carroll, Wilbert Zwart, R Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali