Publications
Publications
Bold text highlights authors supported by the Centre.
#ClinInfra - Supported by our investment in Clinical Infrastructure at the ICR and Imperial
#DataSciInfra - Supported by our investment in Data Science Infrastructure at the ICR
#CanTechCat - Supported by our Cancer Technology Catalyst team
#OtherInfra - Supported by other investments at the ICR and Imperial (e.g. Human Organoid Facility, Microfabrication & Prototyping Facility, Equipment...)
#DevFund - Development fund and other project funding
#NonClinStud - Supported by our Non-Clinical Studentship programme
#CATP - Supported by our Clinical Academic Training Programme
#Affiliation - Authors directly affiliated to the Centre
Signal Enhancement in Immunoassays via Coupling to Catalytic Nanoparticles - ACS Sens. 2025 May 20.
Sadler CJ, Sandler JP, Shamsabadi A, Frenette LC, Creamer A, Stevens MM.
#NonClinStud
Nivolumab plus ipilimumab in hepatocellular carcinoma - Lancet. 2025 May 7:S0140-6736(25)00417-9.
Vithayathil M, Sharma R.
#CATP
Survival in patients receiving reduced dose intensity of bevacizumab for unresectable hepatocellular carcinoma - NPJ Precis Oncol. 2025 May 6;9(1):129.
Ball D, Nault JC, Vithayathil M, Allaire M, Ganne-Carrié N, Campani C, Marra F, Sharma R.
#CATP
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody-Dependent Cytotoxicity - Angew Chem Int Ed Engl. 2025 Apr 24:e202422673.
Tate EW, Bickel JK, Ahmed AIS, Pidd AB, Morgan RM, McAllister TE, Horrell SM, Couves EC, Nagaraj H, Bartlett EJ, El Omari K, Kawamura A, Bubeck D.
#NonClinStud
The use of indocyanine green and near-infrared fluorescence in the detection of metastatic lymph nodes during oesophageal and gastric cancer resection: a systematic review and meta-analysis - Surg Endosc. 2025 Apr 18.
Slim N, Anbu D, Darzi A, Elson DS, Peters CJ.
#OtherInfra
Machine learning based radiomic models outperform clinical biomarkers in predicting outcomes after immunotherapy for hepatocellular carcinoma - J Hepatol. 2025 Apr 15:S0168-8278(25)00244-2.
Vithayathil M, Koku D, Campani C, Nault JC, Sutter O, Carrié NG, Aboagye EO, Sharma R.
#CATP
“Spin-Rinse and Repeat”: Facile Processing to Improve Cytocompatibility of Poly(3,4-Ethyelenedioxythiophene): Polystyrene Sulfonate Composites for Bioelectronics - Adv. NanoBiomed Res. 2400149.
Killilea, J., Lee, A., Cuttaz, E.A., Miceli, G.C., Suquia, L.L., Goding, J.A., Chapman, C.A.R. and Green, R.A.
#CATP
Handheld ISFET Lab-on-Chip detection of YAP1 nucleic acid and AR-FL and AR-V7 mRNA from liquid biopsies for prostate cancer prognosis - Biosens Bioelectron. 2025 Apr 8;281:117407.
Broomfield J, Kalofonou M, Gulli C, Powell SM, Fernandes RC, Leach DA, Moser N, Sarwar N, Mangar S, Bevan CL, Georgiou P.
#NonClinStud
Influence of imaging method on fat fraction estimation for assessing bone marrow in metastatic prostate cancer - Eur Radiol. 2025 Apr 11.
Azma YN, Boci N, Abramowicz K, Russo L, Orton MR, Tunariu N, Koh DM, Charles-Edwards G, Collins DJ, Winfield JM.
#ClinInfra
Effect of drain omission after mastectomy on cosmesis, patient satisfaction and interval to adjuvant therapy - Ann R Coll Surg Engl. 2025 Apr 8.
Hector LR, To N, Leusink AE, Elfadl D, Voynov V, Roche N, Rusby JE.
#CATP
Yurui Ma, Evon Poon, Chenchen Jin, Barbara Martins da Costa, Yuewei Xu, Sadiya Quazi, Nikolaos Zourdoumis, Chiharu Wickremesinghe, Louis Chesler, Hector C Keun, Anke Nijhuis
#NonClinStud
Multimodal imaging platform for enhanced tumor resection in neurosurgery: integrating hyperspectral and pCLE technologies - Int J Comput Assist Radiol Surg. 2025 Apr 3.
Roddan A, Czempiel T, Xu C, Xu H, Weld A, Chalau V, Anichini G, Elson DS, Giannarou S.
#OtherInfra
Gradient system characterization of a 1.5 T MR-Linac with application to 4D UTE imaging for adaptive MR-guided radiotherapy of lung cancer - Magn Reson Med. 2025 Mar 19.
Goodburn R, Bruijnen T, Lecoeur B, Nair P, Ahmed M, Barnes H, Oelfke U, Wetscherek A.
#NonClinStud
Impact of resection margin width on local recurrence following breast-conserving surgery and whole breast radiotherapy for pure ductal carcinoma in situ: a systematic review and meta-analysis - BMJ Oncol. 2025 Mar 6;4(1):e000633.
Ezzat A, Shanthakumar D, Laskar N, Cutress RI, Hadjiminas D, Boland M, Joshi M, Patel R, Grant Y, Naik R, Bakri NAC, Hajev S, Elghazaly H, Holt J, Roddan A, Cleator S, Darzi A, Ashrafian H, Leff DR.
#ClinInfra
Stereotactic body radiotherapy for oligoprogressive disease in androgen suppressed prostate cancer: Primary endpoint analysis of the TRAP trial - Int J Radiat Oncol Biol Phys. 2025 Mar 9:S0360-3016(25)00225-1.
Patel P, Dreibe S, Attard G, Cole A, Diez P, Frew J, Guevara J, Levine D, McDonald F, Mullassery V, Murray J, Parker C, Palaniappan N, Pathmanathan A, Reid A, Suh YE, Syndikus I, Tirona A, Tran A, Tunariu N, van As NJ, Wylie J, Tree AC.
#ClinInfra
Defining the value proposition in diagnostic technology: challenges and opportunities for its understanding and development - a review with a multiperspective reflective analysis - Front Med (Lausanne). 2025 Feb 20;12:1498618.
Soukup T, Zamora-Talaya B, Bahadori S, Luxardo R, Kierkegaard P, Butt O, Kettley-Linsell H, Savva KV, Micocci M, Zhou S, Newman S, Walne S, Peters CJ, Gordon A, Ni M, Buckle P, Hanna GB; NIHR HRC IVD PPIE Team.
#CanTechCat
Epidemiology of cholangiocarcinoma - Eur J Surg Oncol. 2025 Feb;51(2):107064.
Qurashi M, Vithayathil M, Khan SA.
#CATP
The relative contrast ratio of malignant bone lesion is highest on relative Fat Fraction maps compared with T1-weighted and b900 DWI images - Magn Reson Imaging. 2025 Jan 22:110331.
Castagnoli F, Dragan A, Candito A, Tunariu N, Messiou C, Koh DM.
#ClinInfra
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome - J Pathol. 2025 Feb;265(2):198-210.
Trahearn N, Sakr C, Banerjee A, Lee SH, Baker AM, Kocher HM, Angerilli V, Morano F, Bergamo F, Maddalena G, Intini R, Cremolini C, Caravagna G, Graham T, Pietrantonio F, Lonardi S, Fassan M, Sottoriva A.
#DataSciInfra
ctDNA: A Gateway for Personalized Risk Stratification in Surgically Resectable Hepatocellular Cancer - Clin Cancer Res. 2025 Jan 10.
Pinato DJ, Lombardi P, D'Alessio A, Torkpour A, Fulgenzi CAM, Brunetti L.
#CATP
NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth - Clin Cancer Res. 2025 Jan 9.
Welti J, Bogdan D, Figueiredo I, Coleman I, Jiménez Vacas J, Liodaki K, Weigl F, Buroni L, Zeng W, Bernett I, Bertan C, Roumeliotis TI, Bhamra A, Rekowski J, Gurel B, Neeb AJ, Ning J, Li D, Gil VS, Riisnaes R, Miranda S, Crespo M, Ferreira A, Tunariu N, Pasqua E, Chessum N, Cheeseman M, Te Poele R, Powers M, Carreira S, Choudhary J, Clarke P, Banerji U, Swain A, Jones K, Yuan W, Workman P, Nelson PS, de Bono JS, Sharp A.
#ClinInfra
Clinicians' perspectives on the use of artificial intelligence to triage MRI brain scans - Eur J Radiol. 2025 Jan 6;183:111921.
Din M, Daga K, Saoud J, Wood D, Kierkegaard P, Brex P, Booth TC.
#CanTechCat
Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states - Cancer Discov. 2024 Dec 19.
George SL, Lynn C, Stankunaite R, Hughes D, Sauer CM, Chalker J, Waqar Ahmed S, Oostveen M, Proszek PZ, Yuan L, Shaikh R, Jamal S, Brew A, Tall J, Rogers T, Clifford SC, Vormoor J, Shipley JM, Tweddle DA, Jones C, Willis C, Burke GAA, Vedi A, Howell L, Johnston R, Rees H, Adams M, Jesudason A, Ronghe M, Elliott M, Ross E, Makin G, Campbell-Hewson Q, Grundy RG, Turnbull J, Wilson S, Lee V, Gray JC, Stoneham S, Gatz SA, Marshall LV, Angelini P, Anderson J, Cresswell GD, Graham TA, Al-Lazikani B, Cortes-Ciriano I, Kearns P, Hutchinson JC, Hargrave D, Jacques TS, Hubank M, Sottoriva A, Chesler L.
#DataSciInfra
Immune checkpoint inhibitors and the liver: balancing therapeutic benefit and adverse events - Gut. 2024 Dec 10:gutjnl-2024-332125.
De Martin E, Fulgenzi CAM, Celsa C, Laurent-Bellue A, Torkpour A, Lombardi P, D'Alessio A, Pinato DJ.
#CATP
Elucidating acquired PARP inhibitor resistance in advanced prostate cancer - Cancer Cell. 2024 Nov 14:S1535-6108(24)00403-3.
Seed G, Beije N, Yuan W, Bertan C, Goodall J, Lundberg A, Tyler M, Figueiredo I, Pereira R, Baker C, Bogdan D, Gallagher L, Cieslik JP, Greening S, Lambros M, Neves R, Magraner-Pardo L, Fowler G, Ebbs B, Miranda S, Flohr P, Bianchini D, Rescigno P, Porta N, Hall E, Gurel B, Tunariu N, Sharp A, Pettit S, Stoecklein NH, Sandhu S, Quigley D, Lord CJ, Mateo J, Carreira S, de Bono J.
#ClinInfra
Repeatability of quantitative MR fingerprinting for T1 and T2 measurements of metastatic bone in prostate cancer patients - Eur Radiol. 2024 Nov 6.
Rata M, Orton MR, Tunariu N, Curcean A, Hughes J, Scurr E, Blackledge M, d'Arcy J, Jiang Y, Gulani V, Koh DM.
#ClinInfra
Imaging PD-L1 in the brain-Journey from the lab to the clinic - Neuro Oncol. 2024 Oct 28:noae190.
Dar D, Rodak M, Da Pieve C, Gorczewska I, Sharma G, Chmielik E, Niedbala M, Bzowski P, d'Amico A, Bobek-Billewicz B, Nowicka E, Tarnawski R, Kaspera W, Kramer-Marek G.
#NonClinStud
Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Katie Tyson, Sarah Spear, Yuewei Xu, Flora McKinney, Julia Babuta, Chandler Bray, Chiharu Wickremesinghe, Alexandros P Siskos, Anke M Nijhuis, Edward W Tate, Iain A McNeish, Adrian Benito, Hector C Keun
#NonClinStud
Megan Morris, Emily Durie, Victoria Sinnett, Matthieu Toulemonde, Ioannis Roxanis, Steven Allen, Kate Downey, Julie Scudder, Tanja Gagliardi, Pauline Scott-Mackie, Samantha Nimalasena, Jipeng Yan, Biao Huang, Joseph Hansen-Shearer, Lone Gothard, Justine Hughes, Matthew D Blackledge, Navita Somaiah, Meng-Xing Tang
#NonClinStud #CATP #DevFund
Safety and efficacy of itacitinib, a selective JAK1 inhibitor, in advanced hepatocellular cancer: Phase 1b trial (JAKAL) - Future Oncol. 2024 Sep 16:1-9. doi: 10.1080/14796694.2024.2396795.
Troiani A, Martinez M, Ward C, Benartzi CW, Pinato DJ, Sharma R.
#ClinlInfra
Muhammad Habiburrahman, Nahal Masrour, Naina Patel, Anna M Piskorz, Robert Brown, James D Brenton, Iain A McNeish, James M Flanagan.
#ClinInfra
Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer - Cancer Cell. 2024 Sep 16:S1535-6108(24)00317-9.
Calì B, Troiani M, Bressan S, Attanasio G, Merler S, Moscarda V, Mosole S, Ricci E, Guo C, Yuan W, Gallagher L, Lundberg A, Bernett I, Figueiredo I, Arzola RA, Abreut EB, D'Ambrosio M, Bancaro N, Brina D, Zumerle S, Pasquini E, Maddalena M, Lai P, Colucci M, Pernigoni N, Rinaldi A, Minardi D, Morlacco A, Moro FD, Sabbadin M, Galuppini F, Fassan M, Rüschoff JH, Moch H, Rescigno P, Francini E, Saieva C, Modesti M, Theurillat JP, Gillessen S, Wilgenbus P, Graf C, Ruf W, de Bono J, Alimonti A.
#ClinInfra
PoLambRimetry: a multispectral polarimetric atlas of lamb brain - J Biomed Opt. 2024 Sep;29(9):096002.
Mieites V, Anichini G, Qi J, O'Neill K, Conde OM, Elson DS.
#OtherInfra
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer - Oncogene. 2024 Sep 13. doi: 10.1038/s41388-024-03148-4. Epub ahead of print. PMID: 39266679.
Sardar S, McNair CM, Ravindranath L, Chand SN, Yuan W, Bogdan D, Welti J, Sharp A, Ryan NK, Knudsen LA, Schiewer MJ, DeArment EG, Janas T, Su XA, Butler LM, de Bono JS, Frese K, Brooks N, Pegg N, Knudsen KE, Shafi AA.
#ClinInfra
BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity - J Clin Invest. 2024 Sep 17;134(18):e179998.
Westaby D, Jiménez-Vacas JM, Figueiredo I, Rekowski J, Pettinger C, Gurel B, Lundberg A, Bogdan D, Buroni L, Neeb A, Padilha A, Taylor J, Zeng W, Das S, Hobern E, Riisnaes R, Crespo M, Miranda S, Ferreira A, Hanratty BP, Nava Rodrigues D, Bertan C, Seed G, Fenor de La Maza MLD, Guo C, Carmichael J, Grochot R, Chandran K, Stavridi A, Varkaris A, Stylianou N, Hollier BG, Tunariu N, Balk SP, Carreira S, Yuan W, Nelson PS, Corey E, Haffner M, de Bono J, Sharp A.
#CATP #ClinInfra
Recent Electrochemical Advancements for Liquid-Biopsy Nucleic Acid Detection for Point-of-Care Prostate Cancer Diagnostics and Prognostics - Biosensors. 2024; 14(9):443.
Broomfield J, Kalofonou M, Bevan CL, Georgiou P.
#NonClinStud
YAP activation is robust to dilution - Mol Omics. 2024 Sep 16.
Jones I, Arias-Garcia M, Pascual-Vargas P, Beykou M, Dent L, Chaudhuri TP, Roumeliotis T, Choudhary J, Sero J, Bakal C.
#NonClinStud
Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology - Nat Genet. 2024 Sep;56(9):1868-1877.
Kinnersley B, Sud A, Everall A, Cornish AJ, Chubb D, Culliford R, Gruber AJ, Lärkeryd A, Mitsopoulos C, Wedge D, Houlston R.
#DataSciInfra
DrugSynthMC: An Atom-Based Generation of Drug-like Molecules with Monte Carlo Search - J Chem Inf Model. 2024 Sep 9.
Roucairol M, Georgiou A, Cazenave T, Prischi F, Pardo OE.
#OtherInfra
Super-resolved fluorescence imaging utilising accessible stochastic optical reconstruction microscopy (easySTORM) implemented on a low-cost, modular open-source (openFrame) microscope - Measurement Science and Technology. 2024 Sept 2.
Anupam Bharadwaj, Amalesh Kumar, Ranjan Kalita, Rumela Mitra, Amit Sharma, Bithiah G. Jaganathan, Jina Bhattacharyya, Anupam Sarma, Edwin Garcia, Bosanta R. Boruah, Sunil Kumar, Jonathon Lightley, Yuriy Alexandrov, Christopher Dunsby, Mark Neil, and Paul M. W. French
#DevFund
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant - Cancer Cell. 2024 Aug 27:S1535-6108(24)00305-2.
Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundström E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schüller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG.
#ClinInfra
A Topological Gaussian Mixture Model for Bone Marrow Morphology in Leukaemia - Arxiv [Preprint]. 24 Aug 2024.
Qiquan Wang, Anna Song, Antoniana Batsivari, Dominique Bonnet, Anthea Monod
#NonClinStud
Technologies and techniques to improve precision in breast conserving surgery - J Surg Oncol. 2024 Aug 21.
Leff DR.
#ClinInfra
Pitfalls and challenges of peptide nucleic acid immobilisation on carbon surfaces for sequence-specific capturing of nucleic acid biomarkers - Biosens Bioelectron. 2024 Aug 3;264:116634.
Meng X, Petrou L, Kenaan A, Khan D, O'Hare D, Ladame S.
#CATP
Commentary: The North West London Clinical Trials Alliance: efficiency and innovation in clinical trial delivery - Trials. 2024 Jul 29;25(1):509.
Kierkegaard P, Su B, Wong R, Boffito M, Balendra S.
#CanTechCat
Injectable conductive hydrogel electrodes for minimally invasive neural interfaces - J. Mater. Chem. B, 2024.
Kusen Ines; Lee, Aaron; Cuttaz, Estelle; Bailey, Zachary K; Killilea, Joshua; Merlo-Nikpay Aslie, Shirine; Goding, Josef; Green, Rylie.
#CATP
Prospective Study of Non-Contrast, Abbreviated MRI for Hepatocellular Carcinoma Surveillance in Patients with Suboptimal Hepatic Visualisation on Ultrasound - Cancers. 2024; 16(15):2709.
Vithayathil M, Qurashi M, Vicente PR, Alsafi A, Naik M, Graham A, Khan S, Lewis H, Dhar A, Smith B, Selvapatt N, Manousou P, Possamai L, Izadi H, Lim A, Tait P, Sharma R.
#CATP
Stability for Inference with Persistent Homology Rank Functions - Computer Graphics Forum, 43: e15142.
Wang, Q., García-Redondo, I., Faugère, P., Henselman-Petrusek, G. and Monod, A.
#NonClinStud
Opportunities and Challenges in Soft Tissue Sarcoma Risk Stratification in the Era of Personalised Medicine - Curr Treat Options Oncol. 2024 Jul 30.
Chowdhury A, Thway K, Pasquali S, Callegaro D, Gronchi A, Jones RL, Huang PH.
#CATP
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis - Oncogene. 2024 Jul 25.
Leslie TK, Tripp A, James AD, Fraser SP, Nelson M, Sajjaboontawee N, Capatina AL, Toss M, Fadhil W, Salvage SC, Garcia MA, Beykou M, Rakha E, Speirs V, Bakal C, Poulogiannis G, Djamgoz MBA, Jackson AP, Matthews HR, Huang CL, Holding AN, Chawla S, Brackenbury WJ.
#NonClinStud
Synthesis and Functionalization of Biodegradable Second Harmonic Generation Nanoprobes for Cell Targeting - Curr Protoc. 2024 Jul;4(7):e1089. doi: 10.1002/cpz1.1089. PMID: 39034855.
Ulucay E, Bollier P, Spilioti M, Sonay AY, Kalyviotis K, Pantazis P.
#CATP
Simulation of ultrasound backscatter coefficient measurement using the finite element method - Ultrasonics. July 2024,107394, ISSN 0041-624X.
George West, Stewart Haslinger, Jeffrey Bamber, Michael Lowe, Peter Huthwaite, Emma Harris
#NonClinStud
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer - Nat Cancer. 2024 Jul 12. doi: 10.1038/s43018-024-00787-0. Epub ahead of print. PMID: 38997466.
Fernandez-Mateos J, Cresswell GD, Trahearn N, Webb K, Sakr C, Lampis A, Stuttle C, Corbishley CM, Stavrinides V, Zapata L, Spiteri I, Heide T, Gallagher L, James C, Ramazzotti D, Gao A, Kote-Jarai Z, Acar A, Truelove L, Proszek P, Murray J, Reid A, Wilkins A, Hubank M, Eeles R, Dearnaley D, Sottoriva A.
#CATP #DataSciInfra
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance - Nature. 2024 Jul 3.
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A*, Yin D*, Zhang C*.
#Affiliation
The genomic trajectory of ovarian high-grade serous carcinoma can be observed in STIC lesions - J Pathol. 2024 Jul 2.
Cheng Z, Ennis DP, Lu B, Mirza HB, Sokota C, Kaur B, Singh N, Le Saux O, Russo G, Giannone G, Tookman LA, Krell J, Barnes C, McDermott J, McNeish IA.
#ClinInfra
Microbial signatures and continuum in endometrial cancer and benign patients - Microbiome. 2024 Jul 1;12(1):118.
Semertzidou A, Whelan E, Smith A, Ng S, Roberts L, Brosens JJ, Marchesi JR, Bennett PR, MacIntyre DA, Kyrgiou M.
#ClinInfra
A geometric approach to robust medical image segmentation - Med Image Anal. 2024 Jun 29;97:103260.
Santhirasekaram A, Winkler M, Rockall A, Glocker B.
#CATP
On the Limitations of Fractal Dimension as a Measure of Generalization - Arxiv [Preprint]. 4 Jun 2024.
Charlie Tan, Inés García-Redondo, Qiquan Wang, Michael M. Bronstein, Anthea Monod
#NonClinStud
Logistic Variational Bayes Revisited - Arxiv [Preprint]. 2 Jun 2024.
Michael Komodromos, Marina Evangelou, Sarah Filippi
#NonClinStud
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer - bioRxiv [Preprint]. 2024 June 28:2024. 06. 24 .600010.
Jenna Robinson*, Gem Flint*, Ian Garner, Silvia Galli, Thomas E. Maher, Marina K. Kuimova, Ramon Vilar, Iain A. McNeish, Robert Brown, Hector Keun, Marco Di Antonio
#NonClinStud
Evaluating prostate cancer bone metastases response with whole-body MRI: What we know and still need to know - Eur Radiol. 2024 Jun 20.
Padhani AR, Tunariu N, Perez-Lopez R, Tombal B, Lecouvet FE.
#ClinInfra
Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells - Sci Rep. 2024 Jun 26;14(1):14793.
Perea Paizal J, Au SH, Bakal C
#NonClinStud
Stereotactic Body Radiotherapy for Oligoprogression in Castration-Resistant Prostate Cancer: Early Toxicity Analysis of the TRAP Trial - Clin Oncol (R Coll Radiol). 2024 Jun.
Patel PH, Dreibe S, Reid A, Parker C, Murray J, Pathmanathan A, Tirona A, Guevara J, Suh YE, Frew J, Palaniappan N, Syndikus I, Attard G, Tunariu N, Tree AC.
#ClinInfra
Multispectral Mueller matrix imaging: a potential tool to visualize white matter tracts - Proc. SPIE 13010, Tissue Optics and Photonics III, 130100G (18 June 2024).
Verónica Mieites, Giulio Anichini, Ji Qi, Kevin O'Neill, Olga M. Conde, and Daniel S. Elson
#OtherInfra
Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biosensors and Bioelectronics 262 (2024) 116513.
Melina Beykou, Vicky Bousgouni, Nicolas Moser, Pantelis Georgiou, Chris Bakal
#NonClinStud
Description of subgroup reporting in clinical trials of chronic diseases: a meta-epidemiological study - BMJ Open. 2024 Jun 21;14(6):e081315.
Wei L, Butterly E, Rodríguez Pérez J, Chowdhury A, Shemilt R, Hanlon P, McAllister D.
#CATP
Capturing longer term surgical outcome measures as part of routine care of breast cancer patients - Breast. 2024 Jun 5;76:103758.
Leusink AE, Godden AR, Yildirim N, Randawa A, Law R, Rusby JE.
#CATP
RNASEH2B loss and PARP inhibition in advanced prostate cancer - J Clin Invest. 2024 Jun 4:e178278.
Carmichael J, Figueiredo I, Gurel B, Beije N, Yuan W, Rekowski J, Seed G, Carreira S, Bertan C, Fenor de la Maza MLD, Chandran K, Neeb A, Welti J, Gallagher L, Bogdan D, Crespo M, Riisnaes R, Ferreira A, Miranda S, Lu J, Shen MM, Hall E, Porta N, Westaby D, Guo C, Grochot R, Lord CJ, Mateo J, Sharp A, de Bono J.
#CATP #ClinInfra
Optical projection tomography implemented for accessibility and low cost (OPTImAL) - Philos Trans A Math Phys Eng Sci. 2024 Jul 9;382(2274):20230101.
Darling C, Kumar S, Alexandrov Y, de Faye J, Almagro Santiago J, Rýdlová A, Bugeon L, Dallman MJ, Behrens AJ, French PMW, McGinty J.
#Affiliation
How Do Patients Use Self-Care to Manage Nonspecific Symptoms Prior to a Cancer Diagnosis? A Rapid Review to Inform Future Interventions to Reduce Delays in Presentation to Primary Care - European Journal of Cancer Care, vol. 2024, Article ID 5580195, 15 pages, 2024.
Georgia Wilson, Hannah R. Brewer, James M. Flanagan, Christian von Wagner, Yasemin Hirst.
#ClinInfra
Pseudomembranous colitis and Parabacteroides distasonis bacteraemia: a rare clinical presentation - Clin J Gastroenterol. 2024 Jun;17(3):457-460.
Hsu C, Moore-Gillon C, Vithayathil M, Karim S.
#CATP
Chemical tools for profiling the intracellular ADP-ribosylated proteome - RSC Chem Biol. 2024 May 22;5(7):640-651.
Draganov SD, Gruet MJ, Conole D, Balcells C, Siskos AP, Keun HC, Haskard DO, Tate EW.
#NonClinStud
A functional survey of the regulatory landscape of estrogen-receptor-positive breast cancer evolution - Cancer Discov. 2024 May 16.
Barozzi I, Slaven N, Canale E, Lopes R, Amorim Monteiro Barbosa I, Bleu M, Ivanoiu D, Pacini C, Mensa E, Chambers A, Bravaccini S, Ravaioli S, Gyorffy B, Dieci MV, Pruneri G, Galli GG, Magnani L.
#OtherInfra
Clinical implications and molecular features of extracellular matrix networks in soft tissue sarcomas - Clin Cancer Res. 2024 May 29.
Pankova V, Krasny L, Kerrison W, Tam YB, Chadha M, Burns J, Wilding CP, Chen L, Chowdhury A, Perkins E, Lee ATJ, Howell L, Guljar N, Sisley K, Fisher C, Chudasama P, Thway K, Jones RL, Huang PH.
#CATP
Secretome of Cancer-Associated Fibroblasts (CAFs) Influences Drug Sensitivity in Cancer Cells - J Proteome Res. 2024 May 20.
Lau R, Yu L, Roumeliotis TI, Stewart A, Pickard L, Choudhary JS, Banerji U.
#ClinInfra
Robust prostate disease classification using transformers with discrete representations - Int J Comput Assist Radiol Surg. 2024 May 13.
Santhirasekaram A, Winkler M, Rockall A, Glocker B.
#CATP
Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge - Magn Reson Med. 2024 May 10.
Boudreau M, Karakuzu A, Cohen-Adad J, Bozkurt E, Carr M, Castellaro M, Concha L, Doneva M, Dual SA, Ensworth A, Foias A, Fortier V, Gabr RE, Gilbert G, Glide-Hurst CK, Grech-Sollars M, Hu S, Jalnefjord O, Jovicich J, Keskin K, Koken P, Kolokotronis A, Kukran S, Lee NG, Levesque IR, Li B, Ma D, Mädler B, Maforo NG, Near J, Pasaye E, Ramirez-Manzanares A, Statton B, Stehning C, Tambalo S, Tian Y, Wang C, Weiss K, Zakariaei N, Zhang S, Zhao Z, Stikov N; ISMRM Reproducible Research Study Group and the ISMRM Quantitative MR Study Group.
#NonClinStud
Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer - Br J Cancer. 2024 May;130(11):1828-1840.
Alexander J, Schipper K, Nash S, Brough R, Kemp H, Iacovacci J, Isacke C, Natrajan R, Sawyer E, Lord CJ, Haider S.
#CATP
Shining a spotlight on the inclusion of disabled participants in clinical trials: a mixed methods study - Trials. 2024 Apr 26;25(1):281.
Sakuma Y, Miller MLE, Babalis DS, Baker A, Reddi M, Anjum A, Bruton J, Jones KN, Mulla UZ, Taddese H.
#ClinInfra
Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations - BioRxiv. April 20, 2024.
Angelos Vrynas, Sara Arfan, Karishma Satia, Salime Bazban-Shotorbani, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au
#DevFund #OtherInfra
Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer - JCO Precis Oncol. 2024 Apr;8:e2300456.
Shaw JA, Page K, Wren E, de Bruin EC, Kalashnikova E, Hastings R, McEwen R, Zhang E, Wadsley M, Acheampong E, Renner D, Gleason KLT, Ambasager B, Stetson D, Fernandez-Garcia D, Guttery D, Allsopp RC, Rodriguez A, Zimmermann B, Sethi H, Aleshin A, Liu MC, Richards C, Stebbing J, Ali S, Rehman F, Cleator S, Kenny L, Ahmed S, Armstrong AC, Coombes RC.
#ClinInfra
The Lancet Commission on prostate cancer: planning for the surge in cases - Lancet. 2024 Apr 4:S0140-6736(24)00651-2
James ND, Tannock I, N'Dow J, Feng F, Gillessen S, Ali SA, Trujillo B, Al-Lazikani B, Attard G, Bray F, Compérat E, Eeles R, Fatiregun O, Grist E, Halabi S, Haran Á, Herchenhorn D, Hofman M, Jalloh M, Loeb S, MacNair A, Mahal B, Mendes L, Moghul M, Moore C, Morgans A, Morris M, Murphy D, Murthy V, Nguyen PL, Padhani A, Parker C, Rush H, Sculpher M, Soule H, Sydes MR, Tilki D, Tunariu N, Villanti P, Xie LP.
#CanTechCat
CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors - Clin Cancer Res. 2024 Apr 9:OF1-OF12.
Archer S, Brailey PM, Song M, Bartlett PD, Figueiredo I, Gurel B, Guo C, Brucklacher-Waldert V, Thompson HL, Akinwale J, Boyle SE, Rossant C, Birkett NR, Pizzey J, Maginn M, Legg J, Williams R, Johnston CM, Bland-Ward P, de Bono JS, Pierce AJ.
#ClinInfra
Validated machine learning tools to distinguish immune checkpoint inhibitor, radiotherapy, COVID-19 and other infective pneumonitis - Radiother Oncol. 2024 Apr 4:195:110266.
Hindocha S, Hunter B, Linton-Reid K, George Charlton T, Chen M, Logan A, Ahmed M, Locke I, Sharma B, Doran S, Orton M, Bunce C, Power D, Ahmad S, Chan K, Ng P, Toshner R, Yasar B, Conibear J, Murphy R, Newsom-Davis T, Goodley P, Evison M, Yousaf N, Bitar G, McDonald F, Blackledge M, Aboagye E, Lee R.
#CATP
Characterizing functional DNA damage and response caused by the combination of CHK1 and WEE1 inhibitors in ovarian and breast cancer models - BJC Rep 2, 27 (2024).
Adam Stewart, Jiin Song, Lisa Pickard, Giovanna Muggiolu, Sylvie Sauvaigo, Alexis De Haven Brandon, Florence Raynaud & Udai Banerji
#ClinInfra
Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells - Cancer Discov. 2024 Mar 21:OF1-OF24.
Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani
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Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30 - RSC Chem Biol, 2024, Advance Article.
Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W. Auner and Edward W. Tate.
#DevFund
Genome-wide mapping of G-quadruplex DNA: a step-by-step guide to select the most effective method - RSC Chem Biol, 2024, Advance Article.
Silvia Galli, Gem Flint, Lucie Růžičková and Marco Di Antonio
#NonClinStud
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity - Nat Rev Cancer. 2024 Mar 7.
Pascal Meier, Arnaud J. Legrand, Dieter Adam & John Silke
#Affiliation
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets - Nat Rev Cancer. 2024 Feb 29.
Edward W. Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang & Hening Lin
#NonClinStud
Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer - Mol Cancer Ther. 2024 Feb 27.
Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M Jiménez-Vacas, Victor Gourain, Irene I Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel, Jonathan Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, Yija Jiang, Patrizio Di Micco, Borja Mateos, Stasė Bielskutė, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Mateus Crespo, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Stefan Bräse, Nicole Jung, Simone Gräßle, Amanda Swain, Xavier Salvatella, Stephen R Plymate, Bissan Al-Lazikani, Henry W Long, Wei Yuan, Myles Brown, Andrew C B Cato, Johann S de Bono, Adam Sharp
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A first-in-human phase I study of the PD-1 inhibitor, retifanlimab (INCMGA00012), in patients with advanced solid tumors (POD1UM-101) - ESMO Open. 2024 Feb 21;9(4):102254.
Lakhani N, Cosman R, Banerji U, Rasco D, Tomaszewska-Kiecana M, Garralda E, Kornacki D, Li J, Tian C, Bourayou N, Powderly J.
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Circulating microRNA analysis in a prospective co-clinical trial identifies MIR652-3p as a response biomarker and driver of regorafenib resistance mechanisms in colorectal cancer - Clin Cancer Res. 2024 Feb 20.
Somaieh Hedayat, Luciano Cascione, David Cunningham, Marta Schirripa, Andrea Lampis, Jens C Hahne, Nina Tunariu, Sung Pil Hong, Silvia Marchetti, Khurum Khan, Elisa Fontana, Valentina Angerilli, Mia Delrieux, Daniel Nava Rodrigues, Letizia Procaccio, Sheela Rao, David Watkins, Naureen Starling, Ian Chau, Chiara Braconi, Nicos Fotiadis, Ruwaida Begum, Naomi Guppy, Louise Howell, Melanie Valenti, Scott Cribbes, Bernadett Kolozsvari, Vladimir Kirkin, Sara Lonardi, Michele Ghidini, Rodolfo Passalacqua, Raghad Elghadi, Luca Magnani, David J Pinato, Federica Di Maggio, Filippo Ghelardi, Elisa Sottotetti, Guglielmo Vetere, Paolo Ciraci, Georgios Vlachogiannis, Filippo Pietrantonio, Chiara Cremolini, Alessio Cortellini, Fotios Loupakis, Matteo Fassan, Nicola Valeri
#ClinInfra
Fiberbots: Robotic fibers for high-precision minimally invasive surgery - Sci Adv. 2024 Jan 19;10(3):eadj1984.
Mohamed E.M.K. Abdelaziz, Jinshi Zhao, Bruno Gil Rosa, Hyun-Taek Lee, Daniel Simon, Khushi Vyas, Bing Li, Hanifa Koguna, Yue Li, Ali Anil Demircali, Huseyin Uvet, Gulsum Gencoglan, Arzu Akcay, Mohamed Elriedy, James Kinross, Ranan Dasgupta, Zoltan Takats, Eric Yeatman, Guang-Zhong Yang, Burak Temelkuran
#DevFund
Deep Learning for Delineation of the Spinal Canal in Whole-Body Diffusion-Weighted Imaging: Normalising Inter- and Intra-Patient Intensity Signal in Multi-Centre Datasets - Bioengineering (Basel). 2024 Jan 29;11(2):130.
Antonio Candito, Richard Holbrey, Ana Ribeiro, Christina Messiou, Nina Tunariu, Dow-Mu Koh, Matthew D Blackledge
#ClinInfra
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase - J Med Chem. 2024 Jan 25;67(2):1061-1078.
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A. Andrei, Olivia Boyd, Naoko Masumoto, Ursula R. Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I. Raynaud, Rosemary Burke, Julian Blagg, Henry S. Rzepa, Christian Siebold, Anthony I. Magee, Thomas Lanyon-Hogg, and Edward W. Tate
#NonClinStud #DevFund
Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment - Int J Surg. 2024 Jan 22.
Scarlet Nazarian, Ioannis Gkouzionis, Jamie Murphy, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson
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A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation - Nat Biotechnol. 2024 Jan 8.
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Jack W. Houghton, Susana A. Palma-Duran, James I. MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S. Eggert & Edward W. Tate
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Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2024 Jan 16;134(2):e175369.
Magnus T Dillon, Jeane Guevara, Kabir Mohammed, Emmanuel C Patin, Simon A Smith, Emma Dean, Gemma N Jones, Sophie E Willis, Marcella Petrone, Carlos Silva, Khin Thway, Catey Bunce, Ioannis Roxanis, Pablo Nenclares, Anna Wilkins, Martin McLaughlin, Adoracion Jayme-Laiche, Sarah Benafif, Georgios Nintos, Vineet Kwatra, Lorna Grove, David Mansfield, Paula Proszek, Philip Martin, Luiza Moore, Karen E Swales, Udai Banerji, Mark P Saunders, James Spicer, Martin D Forster, Kevin J Harrington
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Exposure to Aldehyde Cherry e-Liquid Flavoring and Its Vaping Byproduct Disrupt Pulmonary Surfactant Biophysical Function - Environ Sci Technol. 2024 Jan 8.
Alexia Martin, Carmelo Tempra, Yuefan Yu, Juho Liekkinen, Roma Thakker, Hayoung Lee, Berta de Santos Moreno, Ilpo Vattulainen, Christos Rossios, Matti Javanainen, Jorge Bernardino de la Serna
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T-cell receptor determinants of response to chemoradiation in locally-advanced HPV16-driven malignancies - Front Oncol. 2024 Jan 3;13:1296948.
Nenclares P, Larkeryd A, Manodoro F, Lee JY, Lalondrelle S, Gilbert DC, Punta M, O'Leary B, Rullan A, Sadanandam A, Chain B, Melcher A, Harrington KJ, Bhide SA.
#DataSciInfra
O-RADS MRI scoring system has the potential to reduce the frequency of avoidable adnexal surgery - Eur J Obstet Gynecol Reprod Biol. 2024 Jan 17:294:135-142.
Yohann Dabi, Andrea Rockall, Léo Razakamanantsoa, Adalgisa Guerra, Laure S Fournier, Christina Fotopoulou, Cyril Touboul, Isabelle Thomassin-Naggara; Eurad Study Group
#ClinInfra
2023
Optimizing the FDA's Project Optimus: opportunities and challenges - Nat Rev Clin Oncol. 2023 Dec 21.
Simon Rodney & Udai Banerji
#ClinInfra
Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study - Invest Radiol. 2023 Dec 1;58(12):823-831.
Rockall AG, Li X, Johnson N, Lavdas I, Santhakumaran S, Prevost AT, Punwani S, Goh V, Barwick TD, Bharwani N, Sandhu A, Sidhu H, Plumb A, Burn J, Fagan A, Wengert GJ, Koh DM, Reczko K, Dou Q, Warwick J, Liu X, Messiou C, Tunariu N, Boavida P, Soneji N, Johnston EW, Kelly-Morland C, De Paepe KN, Sokhi H, Wallitt K, Lakhani A, Russell J, Salib M, Vinnicombe S, Haq A, Aboagye EO, Taylor S, Glocker B.
#ClinInfra
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation - J Clin Invest. 2023 Nov 7:e175369.
Dillon MT, Guevara J, Mohammed K, Patin EC, Smith SA, Dean E, Jones GN, Willis SE, Petrone M, Silva C, Thway K, Bunce C, Roxanis I, Nenclares P, Wilkins A, McLaughlin M, Jayme-Laiche A, Benafif S, Nintos G, Kwatra V, Grove L, Mansfield DC, Proszek P, Martin P, Moore L, Swales KE, Banerji U, Saunders MP, Spicer J, Forster MD, Harrington KJ.
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The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis - Front Bioeng Biotechnol. 2023 Nov 29:11:1305936.
Stylianos Kechagias, Konstantinos Theodoridis, Joseph Broomfield, Kenny Malpartida-Cardenas, Ruth Reid, Pantelis Georgiou, Richard J van Arkel, Jonathan R T Jeffers
#NonClinStud
Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases - Br J Radiol. 2023 Nov;96(1151):20230378.
Donners R, Candito A, Blackledge M, Rata M, Messiou C, Koh DM, Tunariu N.
#ClinInfra
Group Spike and Slab Variational Bayes - Arxiv [Preprint]. 15 Nov 2023
Michael Komodromos, Marina Evangelou, Sarah Filippi, Kolyan Ray
#NonClinStud
Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications - Biorxiv. November 23, 2023.
Melina Beykou, Vicky Bousgouni, Nicolas Moser, Pantelis Georgiou, Chris Bakal
#NonClinStud
Radiomics-based decision support tool assists radiologists in small lung nodule classification and improves lung cancer early diagnosis - Br J Cancer. 2023 Nov 6.
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian McNamara, Toby Burn, Emily Guilhem, Marcos Mestas Nuñez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye & Anand Devaraj
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Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response - JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad077.
Parker C, Tunariu N, Tovey H, Alonzi R, Blackledge MD, Cook GJR, Chua S, Du Y, Hafeez S, Murray I, Padhani AR, Staffurth J, Tree A, Stidwill H, Finch J, Curcean A, Chatfield P, Perry S, Koh DM, Hall E.
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Relative fat fraction of malignant bone lesions from breast cancer, prostate cancer and myeloma are significantly lower than normal bone marrow and shows excellent interobserver agreement. - Br J Radiol. 2023 Oct 31:20230240.
Castagnoli F, Donners R, Tunariu N, Messiou C, Koh DM.
#ClinInfra
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma - Cell Rep. 2023 Oct 31;42(10):113307.
Yuewei Xu, Sarah Spear, Yurui Ma, Marc P Lorentzen, Michael Gruet, Flora McKinney, Yitao Xu, Chiharu Wickremesinghe, Madelen R Shepherd, Iain McNeish, Hector C Keun, Anke Nijhuis
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Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance - Nature. 2023 Oct 16.
Christina Guo, Adam Sharp, Bora Gurel, Mateus Crespo, Ines Figueiredo, Suneil Jain, Ursula Vogl, Jan Rekowski, Mahtab Rouhifard, Lewis Gallagher, Wei Yuan, Suzanne Carreira, Khobe Chandran, Alec Paschalis, Ilaria Colombo, Anastasios Stathis, Claudia Bertan, George Seed, Jane Goodall, Florence Raynaud, Ruth Ruddle, Karen E. Swales, Jason Malia, Denisa Bogdan, Crescens Tiu, Reece Caldwell, Caterina Aversa, Ana Ferreira, Antje Neeb, Nina Tunariu, Daniel Westaby, Juliet Carmichael, Maria de los Dolores Fenor de la Maza, Christina Yap, Ruth Matthews, Hannah Badham, Toby Prout, Alison Turner, Mona Parmar, Holly Tovey, Ruth Riisnaes, Penny Flohr, Jesus Gil, David Waugh, Shaun Decordova, Anna Schlag, Bianca Calì, Andrea Alimonti & Johann S. de Bono
#ClinInfra
Ravindhi Murphy, Gurvin Chander, Maria Martinez, Caroline Ward, Sairah R. Khan, Mitesh Naik, Tara Barwick, Eric Aboagye, Rohini Sharma
#ClinInfra
The Biomarker Toolkit — an evidence-based guideline to predict cancer biomarker success and guide development - BMC Med. 2023 Oct 4;21(1):383.
Katerina-Vanessa Savva, Michal Kawka, Bhamini Vadhwana, Rahul Penumaka, Imogen Patton, Komal Khan, Claire Perrott, Saranya Das, Maxime Giot, Stella Mavroveli, George B Hanna, Melody Zhifang Ni, Christopher J Peters
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Olaparib and celarasertib (AZD6738) in patients with triple negative advanced breast cancer: results from Cohort E of the plasmaMATCH trial (CRUK/15/010) - Clin Cancer Res. 2023 Sep 29.
Ring A, Kilburn LS, Pearson A, Moretti L, Afshari-Mehr A, Wardley AM, Gurel B, Macpherson IR, Riisnaes R, Baird RD, Martin S, Roylance R, Johnson H, Ferreira A, Winter MC, Dunne K, Copson E, Hickish T, Burcombe R, Randle K, Serra V, Llop-Guevara A, Bliss JM, Turner NC.
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The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer - J Clin Invest. 2023 Sep 26:e169200.
Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L.
#ClinInfra
Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma - Br J Cancer. 2023 Sep;129(5):811-818.
Lopez J, Lai-Kwon J, Molife R, Welsh L, Tunariu N, Roda D, Fernández-García P, Lladó V, McNicholl AG, Rosselló CA, Taylor RJ, Azaro A, Rodón J, Sludden J, Veal GJ, Plummer R, Urruticoechea A, Lahuerta A, Mujika K, Escribá PV. A.
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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response - Nat Genet. 2023 Aug;55(8):1311-1323.
Philip Bland, Harry Saville, Patty T. Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E. Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N. Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, …Rachael Natrajan
#CATP
Development and Validation of a New BAG-1L-Specific Antibody to Quantify BAG-1L Protein Expression in Advanced Prostate Cancer - Lab Invest. 2023 Aug 29;103(11):100245.
Neeb A, Figueiredo I, Gurel B, Nava Rodrigues D, Rekowski J, Riisnaes R, Ferreira A, Miranda S, Crespo M, Westaby D, de Los Dolores Fenor de La Maza M, Guo C, Carmichael J, Grochot R, Tunariu N, Cato ACB, Plymate SR, de Bono JS, Sharp A.
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The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases - Eur Radiol. 2023 Aug 24.
Donners R, Tunariu N, Tovey H, Hall E, Chua S, Cook G, Du Y, Blackledge MD, Parker CC, Koh DM.
#ClinInfra
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells - Nat Cancer. 2023 Aug;4(8):1102-1121.
Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A.
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openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation - J Microsc. 2023 Aug 24.
Jonathan Lightley, Sunil Kumar, M Q Lim, E Garcia, F Görlitz, Y Alexandrov, T Parrado, C Hollick, E Steele, K Roßmann, J Graham, J Broichhagen, I A McNeish, C A Roufosse, M A A Neil, Chris Dunsby, P M W French
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Accelerating 4D image reconstruction magnetic resonance-guided radiotherapy - Phys Imaging Radiat Oncol. 2023 Aug 23.
Bastien Lecoeur, Marco Barbone, Jessica Gough, Uwe Oelfke, Wayne Luk, Georgi Gaydadjiev, Andreas Wetscherek
#NonClinStud #DevFund
Participatory evaluation of the process of co-producing resources for the public on data science and artificial intelligence - Res Involv Engagem. 2023 Aug 14;9(1):67.
Piotr Teodorowski, Kelly Gleason, Jonathan J. Gregory, Martha Martin, Reshma Punjabi, Suzanne Steer, Serdar Savasir, Pournamy Vema, Kabelo Murray, Helen Ward & Dorota Chapko
#Affiliation #OtherInfra
The clinical terrain of immunotherapies in heterogeneous pancreatic cancer: unravelling challenges and opportunities - J Pathol. 2023 Aug 7.
Melanie Herpels, Jun Ishihara, Anguraj Sadanandam
#CATP
Handheld ISFET Lab-on-Chip detection of TMPRSS2-ERG and AR mRNA for prostate cancer prognostics - IEEE Sens Lett. 2023 Aug;7(8):1-4.
Joseph Broomfield, Melpomeni Kalofonou, Sylvia Franklin, Sue M Powell, Thomas Pataillot-Meakin, Nicolas Moser, Charlotte L Bevan, Pantelis Georgiou
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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target - Nat Metab. 2023 Aug;5(8):1303-1318.
Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch & Owen J. Sansom
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Role of procalcitonin in predicting complications of Kawasaki disease - Arch Dis Child. 2023 Jul 31;archdischild-2023-325787.
Kazuki Iio, Heather Hanna, Melina Beykou, Chris Gale, Jethro Adam Herberg
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Classification of nucleic acid amplification on ISFET arrays using spectrogram-based neural networks - Comput Biol Med. 2023 Jul;161:107027.
Prateek Tripathi, Costanza Gulli, Joseph Broomfield, George Alexandrou, Melpomeni Kalofonou, Charlotte Bevan, Nicolas Moser, Pantelis Georgiou
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Unbiased differential proteomic profiling between cancer-associated fibroblasts and cancer cell lines - J Proteomics. 2023 Jul 20;104973.
Rachel Lau, Lu Yu, Theodoros I Roumeliotis, Adam Stewart, Lisa Pickard, Ruth Riisanes, Bora Gurel, Johann S de Bono, Jyoti S Choudhary, Udai Banerji
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Proteome-wide structural analysis identifies warhead- and coverage-specific biases in cysteine-focused chemoproteomics - Cell Chem Biol. 2023 Jul 20;30(7):828-838.e4.
Matthew E.H. White, Jesus Gil, Edward W. Tate
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Clinical trial designs for evaluating and exploiting cancer evolution - Cancer Treat Rev. 2023 Jul;118:102583.
Alvaro H Ingles Garces, Nuria Porta, Trevor A Graham, Udai Banerji
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The potential role of the microbiota in prostate cancer pathogenesis and treatment. - Nat Rev Urol. 2023 Jul 25.
Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, Liu L, Maraccani L, Guccini I, Migliorini D, de Bono J, Alimonti A.
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Critical role of antioxidant programs in enzalutamide-resistant prostate cancer - Oncogene. 2023 Jul;42(30):2347-2359.
Blatt EB, Parra K, Neeb A, Buroni L, Bogdan D, Yuan W, Gao Y, Gilbreath C, Paschalis A, Carreira S, DeBerardinis RJ, Mani RS, de Bono JS, Raj GV.
#ClinInfra
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer - Br J Cancer. 2023 Jul;129(1):38-45.
Rebecca Kristeleit, Ruth Plummer, Robert Jones, Louise Carter, Sarah Blagden, Debashis Sarker, Tobias Arkenau, Thomas R Jeffry Evans, Sarah Danson, Stefan N Symeonides, Gareth J Veal, Barbara J Klencke, Mark M Kowalski, Udai Banerji
#ClinInfra
Circulating Tumor Cell Cluster Sorting by Size and Asymmetry - Methods Mol Biol. 2023;2679:15-23.
Sam H Au
#OtherInfra
Dynamics and Molecular Interactions of GPI-Anchored CD59 - Toxins 2023, 15(7), 430.
Tomas B. Voisin, Emma C. Couves, Edward W. Tate and Doryen Bubeck
#NonClinStud
Cancer Loyalty Card Study (CLOCS): feasibility outcomes for an observational case-control study focusing on the patient interval in ovarian cancer - BMJ Open. 2023 Jun 14;13(6):e066022.
Hannah R Brewer, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James Flanagan, Yasemin Hirst
#ClinInfra
Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma - Cancers (Basel). 2023 Jun 9;15(12):3131.
Gitanjali Sharma, Marta C Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H Plate, Wojciech Kaspera, Gabriela Kramer-Marek
#NonClinStud
Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19 - Sci Rep. 2023 Jun 29;13(1):10568.
Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. Aboagye, Richard W. Lee & Matthew D. Blackledge
#CATP
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer - Br J Cancer. 2023 Jun;128(12):2326-2337.
Theodora A. Constantin, Anabel Varela-Carver, Kyle K. Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A. Leach, Chun-Fui Lai, Edward K. Ainscow, Ash K. Bahl, David Carling, Matthew J. Fuchter, Simak Ali & Charlotte L. Bevan
#ClinInfra
Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer? - Prostate Cancer Prostatic Dis. 2023 Jun;26(2):282-286.
Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed & Mathias Winkler
#CATP
Hannah R. Brewer, Qianhui Jiang, Sudha Sundar, Yasemin Hirst, James M. Flanagan
#ClinInfra
Distributed large-scale graph processing on FPGAs - J Big Data. 2023;10(1):95.
Amin Sahebi, Marco Barbone, Marco Procaccini, Wayne Luk, Georgi Gaydadjiev, Roberto Giorgi
#NonClinStud #DevFund
Advanced MR Techniques for Preoperative Glioma Characterization: Part 1 & Part 2 - J Magn Reson Imaging. 2023 Jun;57(6):1676-1695
[...], Simran Kukran, [...]
#NonClinStud
Capillary-Scale Hydrogel Microchannel Networks by Wire Templating - Small 2023 Jun 2;e2301163.
Shusei Kawara, Brian Cunningham, James Bezer, Neelima Kc, Jingwen Zhu, Meng-Xing Tang, Jun Ishihara, James J Choi, Sam H Au
#NonClinStud #OtherInfra
A YOLOv5-based network for the detection of a diffuse reflectance spectroscopy probe to aid surgical guidance in gastrointestinal cancer surgery - Int J Comput Assist Radiol Surg. 2023 Jun 8.
Ioannis Gkouzionis, Yican Zhong, Scarlet Nazarian, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson
#NonClinStud
Triaxial accelerometer-measured physical activity and functional behaviours among people with High Grade Glioma: The BrainWear Study - PLoS One. 2023 May 24;18(5):e0285399.
Seema Dadhania, Lillie Pakzad-Shahabi, Sanjay Mistry, Matt Williams
#CATP
Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives - Cancer Imaging. 2023 May 31;23(1):53.
Lother D, Robert M, Elwood E, Smith S, Tunariu N, Johnston SRD, Parton M, Bhaludin B, Millard T, Downey K, Sharma B.
#ClinInfra
Active mesh and neural network pipeline for cell aggregate segmentation - Biophys J. 2023 May 2;122(9):1586-1599.
Matthew B Smith, Hugh Sparks, Jorge Almagro, Agathe Chaigne, Axel Behrens, Chris Dunsby, Guillaume Salbreux
#Affiliation
Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer - Microbiome. 2023 May 8;11(1):100.
James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare & James Kinross
#NonClinStud
Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function - Int J Mol Sci. 2023 May 15;24(10):8806.
Mahmoud I Khalil, Heba M Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E Pardo
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Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth - Cell Death Discov. 2023 May 19;9(1):172.
Judith Schaf, Sonia Shinhmar, Qingyu Zeng, Olivier E. Pardo, Philip Beesley, Nelofer Syed & Robin S. B. Williams
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REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment - Lancet Oncol. 2023 May;24(5):e219-e227.
Ehsan Ghorani, Matteo Quartagno, Fiona Blackhall, Duncan C Gilbert, Mary O'Brien, Christian Ottensmeier, Elena Pizzo, James Spicer, Alex Williams, Philip Badman, Mahesh K B Parmar, Michael J Seckl; REFINE-Lung Investigators
#ClinInfra
Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer - Eur Urol Open Sci. 2023 May 2;52:72-78. doi: 10.1016/j.euros.2023.04.003.
Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb, Bora Gurel, Maria de Los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Daniel Westaby, Joaquin Mateo, Adam Sharp, Terri P McVeigh, Johann De Bono
#CATP #ClinInfra
A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation - BioRxiv 2023.04.18.537386.
Cory A. Ocasio, Marc P. Baggelaar, James Sipthorp, Ana Losada de la Lastra, Jana Volarić, Christelle Soudy, Elisabeth M. Storck, Susana A. Palma-Duran, James I. MacRae, Goran Tomic, Lotte Carr, Julian Downward, Ulrike S. Eggert, Edward W. Tate
#NonClinStud
A Transgender Patient with Prostate Cancer: Lessons Learnt - Eur Urol. 2023 Apr;83(4):379-380.
Khobe Chandran, Rafael Grochot, Maria de Los Dolores Fenor De La Maza, Wei Yuan, Bora Gurel, Susana Miranda, Alec Paschalis, Ruth Riisnaes, Ines Figueiredo, Denisa Bogdan, Adam Sharp, Suzanne Carreira, Johann S de Bono
#ClinInfra
Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature. 2023 Apr;616(7957):563-573.
Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A. Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T. C. Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R. M. Black, Thomas B. K. Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M. Frankell, Maise Al Bakir, Emilia L. Lim, Mark S. Hill, Gareth A. Wilson, Daniel E. Cook, Nicolai J. Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, TRACERx Consortium, CAPTURE Consortium, Crispin T. Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward & George Kassiotis
#Affiliation
Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma - Hepatol Int. 2023 Apr 1.
Mathew Vithayathil, Antonio D’Alessio, Claudia Angela Maria Fulgenzi, Naoshi Nishida, Martin Schönlein, Johann von Felden, Kornelius Schulze, Henning Wege, Anwaar Saeed, Brooke Wietharn, Hannah Hildebrand, Linda Wu, Celina Ang, Thomas U. Marron, Arndt Weinmann, Peter R. Galle, Dominik Bettinger, Bertram Bengsch, Arndt Vogel, Lorenz Balcar, Bernhard Scheiner, Pei-Chang Lee, Yi-Hsiang Huang, Suneetha Amara, Mahvish Muzaffar, Abdul Rafeh Naqash, Antonella Cammarota, Valentina Zanuso, Tiziana Pressiani, Matthias Pinter, Alessio Cortellini, Masatoshi Kudo, Lorenza Rimassa, David J. Pinato & Rohini Sharma
#ClinInfra
Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain - Sci Rep. 2023 Apr 28;13(1):6963.
William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse
#NonClinStud
Acceleration-Based Kalman Tracking for Super-Resolution Ultrasound Imaging in vivo - Arxiv
Biao Huang, Jipeng Yan, Megan Morris, Victoria Sinnett, Navita Somaiah, Meng-Xing Tang
#NonClinStud
What is so Special About Digital Health in Cancer? - Clin Oncol (R Coll Radiol). 2023 Mar;35(3):147-149.
S Dadhania, M Williams
#CATP
Progression patterns and therapeutic sequencing following immune checkpoint inhibition for hepatocellular carcinoma: An international observational study - Liver Int. 2023 Mar;43(3):695-707
Thomas Talbot, Antonio D'Alessio, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U. Marron, Tomi Jun, Sirish Dharmapuri, Celina Ang, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Claudia A. M. Fulgenzi, Suneetha Amara, Abdul Rafeh Naqash, Anuhya Gampa, Anjana Pillai, Yinghong Wang, Uqba Khan, Pei-Chang Lee, Yi-Hsiang Huang, Bertram Bengsch, Dominik Bettinger, Yehia I. Mohamed, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Masatoshi Kudo, Arndt Weinmann, Peter R. Galle, Ambreen Muhammed, Alessio Cortellini, Arndt Vogel, David J. Pinato
#ClinInfra
B7-H3 as a Therapeutic Target in Advanced Prostate Cancer - Eur Urol. 2023 Mar;83(3):224-238.
Christina Guo, Ines Figueiredo, Bora Gurel, Antje Neeb, George Seed, Mateus Crespo, Suzanne Carreira, Jan Rekowski, Lorenzo Buroni, Jon Welti, Denisa Bogdan, Lewis Gallagher, Adam Sharp, Maria D Fenor de la Maza, Pasquale Rescigno, Daniel Westaby, Khobe Chandran, Ruth Riisnaes, Ana Ferreira, Susana Miranda, Bianca Calì, Andrea Alimonti, Silvia Bressan, Alana H T Nguyen, Michael M Shen, Jessica E Hawley, Aleksandar Obradovic, Charles G Drake, Claudia Bertan, Chloe Baker, Nina Tunariu, Wei Yuan, Johann S de Bono
#ClinInfra
Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting - Adv Mater. 2023 Mar 11;e2300413.
Adam Creamer, Alessandra Lo Fiego, Alice Agliano, Lino Prados-Martin, Håkon Høgset, Adrian Najer, Daniel A. Richards, Jonathan P. Wojciechowski, James E. J. Foote, Nayoung Kim, Amy Monahan, Jiaqing Tang, André Shamsabadi, Léa N. C. Rochet, Ioanna A. Thanasi, Laura R. de la Ballina, Charlotte L. Rapley, Stephen Turnock, Elizabeth A. Love, Laurence Bugeon, Margaret J. Dallman, Martin Heeney, Gabriela Kramer-Marek, Vijay Chudasama, Federico Fenaroli, Molly M. Stevens
#DevFund
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer. - Cancer Cell. 2023 Mar 13;41(3):602-619.e11.
Bancaro N, Calì B, Troiani M, Elia AR, Arzola RA, Attanasio G, Lai P, Crespo M, Gurel B, Pereira R, Guo C, Mosole S, Brina D, D'Ambrosio M, Pasquini E, Spataro C, Zagato E, Rinaldi A, Pedotti M, Di Lascio S, Meani F, Montopoli M, Ferrari M, Gallina A, Varani L, Pereira Mestre R, Bolis M, Gillessen Sommer S, de Bono J, Calcinotto A, Alimonti A.
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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth - Oncogene. 2023 Mar;42(12):926-937.
Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann & Jennifer Munkley,
#CATP #ClinInfra
PETAL protocol: a phase Ib study of pembrolizumab after transarterial chemoembolization in hepatocellular carcinoma - Future Oncol. 2023 Mar;19(7):499-507. doi: 10.2217/fon-2022-0916.
Petros Fessas, Bernhard Scheiner, Antonio D'Alessio, Claudia A M Fulgenzi, James Korolewicz, Caroline Ward, Paul Tait, Robert Thomas, Alessio Cortellini, Rohini Sharma, David J Pinato
#ClinInfra
Apoptosis-modulatory miR-361-3p as a novel treatment target in endocrine-responsive and endocrine-resistant breast cancer - J Endocrinol. 2023 Feb 11;256(3):e220229.
J N Zamarbide Losada, E Sulpice, S Combe, G S Almeida, D A Leach, J Choo, L Protopapa, M P Hamilton, S McGuire, X Gidrol, C L Bevan, C E Fletcher
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Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste T. Jurgaityte, Ash K. Bahl, Simak Ali, Abhay Kotecha, Basil J. Greber
#OtherInfra
Association Between Purchase of Over-the-Counter Medications and Ovarian Cancer Diagnosis in the Cancer Loyalty Card Study (CLOCS): Observational Case-Control Study - JMIR Public Health Surveill. 2023 Jan 26;9:e41762.
Hannah R Brewer, Yasemin Hirst, Marc Chadeau-Hyam, Eric Johnson, Sudha Sundar, James M Flanagan
#ClinInfra
Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer - Gene. 2023 Jan 20;850:146930.
Uttom Kumar, Marcos Castellanos-Uribe, Sean T May, Ernesto Yagüe
#OtherInfra
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways - Reprod Biol Endocrinol. 2023 Jan 26;21(1):9.
María Cristina Carbajo-García, Elena Juarez-Barber, Marina Segura-Benítez, Amparo Faus, Alexandra Trelis, Javier Monleón, Greta Carmona-Antoñanzas, Antonio Pellicer, James M Flanagan, Hortensia Ferrero
#ClinInfra
A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res. 2023 Jan 17;29(2):331-340.
Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji
#ClinInfra
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice - Nat Protoc 2022 Dec 9.
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
#Affiliation
Immune Biomarkers in Metastatic Castration-resistant Prostate Cancer - Eur Urol Oncol. 2022 Dec;5(6):659-667.
María Dolores Fenor de la Maza, Khobe Chandran, Jan Rekowski, Irene M Shui, Bora Gurel, Emily Cross, Suzanne Carreira, Wei Yuan, Daniel Westaby, Susana Miranda, Ana Ferreira, George Seed, Mateus Crespo, Ines Figueiredo, Claudia Bertan, Veronica Gil, Ruth Riisnaes, Adam Sharp, Daniel Nava Rodrigues, Pasquale Rescigno, Nina Tunariu, Xiao Qiao Liu, Razvan Cristescu, Charles Schloss, Christina Yap, Johann S de Bono
#CATP #ClinInfra
Dissecting the Tumor Microenvironment to Predict Immunotherapy Response in Hepatocellular Cancer - Gastroenterology. 2022 Dec;163(6):1712-1713.
Antonio D'Alessio, David J Pinato
#ClinInfra
Matthew E. H. White, Jesús Gil, Edward W. Tate
#NonClinStud
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion - J Am Chem Soc
Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate
#NonClinStud
A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules - EBioMedicine. 2022 Dec:86:104344.
Benjamin Hunter, Mitchell Chen, Prashanthi Ratnakumar, Esubalew Alemu, Andrew Logan, Kristofer Linton-Reid, Daniel Tong, Nishanthi Senthivel, Amyn Bhamani, Susannah Bloch, Samuel V Kemp, Laura Boddy, Sejal Jain, Shafick Gareeboo, Bhavin Rawal, Simon Doran, Neal Navani, Arjun Nair, Catey Bunce, Stan Kaye, Matthew Blackledge, Eric O Aboagye, Anand Devaraj, Richard W Lee
#CATP
Differential Expression of RSK4 Transcript Isoforms in Cancer and Its Clinical Relevance - Int J Mol Sci. 2022 Nov 23;23(23):14569.
Sisi Chen, Michael J Seckl, Marc P G Lorentzen, Olivier E Pardo
#OtherInfra
A multicentre study of pembrolizumab time-of-day infusion patterns and clinical outcomes in non-small-cell lung cancer: too soon to promote morning infusions - Ann Oncol. 2022 Nov;33(11):1202-1204.
A Cortellini, A P C Barrichello, J V Alessi, B Ricciuti, V R Vaz, T Newsom-Davis, J S Evans, G Lamberti, F Pecci, P Viola, A D'Alessio, C A M Fulgenzi, M M Awad, D J Pinato
#ClinInfra
A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res 2022 Nov 15;CCR-22-2074.
Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji
#ClinInfra
Multi-omics signatures of the human early life exposome - Nat Commun. 2022 Nov 21;13(1):7024.
Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Chatzi, Amrit K. Sakhi, Cathrine Thomsen, Ibon Tamayo, Mark Nieuwenhuijsen, Jose Urquiza, Eva Borràs, Eduard Sabidó, Inés Quintela, Ángel Carracedo, Xavier Estivill, Muireann Coen, Juan R. González, Hector C. Keun & Martine Vrijheid
#NonClinStud
Epigenetic potentiation of somatostatin-2 by guadecitabine in neuroendocrine neoplasias as a novel method to allow delivery of peptide receptor radiotherapy - Eur J Cancer. 2022 Nov:176:110-120.
Joanne S Evans, Jamie Beaumont, Marta Braga, Nahal Masrour, Francesco Mauri, Alice Beckley, Shamus Butt, Christina S Karali, Chris Cawthorne, Stephen Archibald, Eric O Aboagye, Rohini Sharma
#NonClinStud
Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife)-A Prospective Pilot Study of Diagnostic Accuracy - Cancers (Basel). 2022 Nov 29;14(23):5892.
Diana Marcus, David L Phelps, Adele Savage, Julia Balog, Hiromi Kudo, Roberto Dina, Zsolt Bodai, Francesca Rosini, Jacey Ip, Ala Amgheib, Julia Abda, Eftychios Manoli, James McKenzie, Joseph Yazbek, Zoltan Takats, Sadaf Ghaem-Maghami
#CATP
A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer - Clin Cancer Res 2022 Nov 1;28(21):4634-4641.
Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, Alvaro Ingles Garces, Andrea Biondo, Ionut-Gabriel Funingana, Martin Little, Ruth Ruddle, Florence Raynaud, Ruth Riisnaes, Bora Gurel, Sue Chua, Nina Tunariu, Joanna C Porter, Toby Prout, Mona Parmar, Anna Zachariou, Alison Turner, Ben Jenkins, Stuart McIntosh, Ed Ainscow, Anna Minchom, Juanita Lopez, Johann de Bono, Robert Jones, Emma Hall, Natalie Cook, Bristi Basu, Udai Banerji
#ClinInfra
Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy - J Microsc 2022 Nov;288(2):130-141.
Jonathan Lightley, Frederik Görlitz, Sunil Kumar, Ranjan Kalita, Arinbjorn Kolbeinsson, Edwin Garcia, Yuriy Alexandrov, Vicky Bousgouni, Riccardo Wysoczanski, Peter Barnes, Louise Donnelly, Chris Bakal, Christopher Dunsby, Mark A A Neil, Seth Flaxman, Paul M W French
#DevFund
Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin Assessment - JAMA Surg 2022 Nov 1;157(11):e223899.
Scarlet Nazarian, Ioannis Gkouzionis, Michal Kawka, Marta Jamroziak, Josephine Lloyd, Ara Darzi, Nisha Patel, Daniel S Elson, Christopher J Peters
#NonClinStud
Robotic large-area optical biopsy imaging for automated detection of gastrointestinal cancers tested in tissue phantoms and ex vivo porcine bowel - Transl Biophotonics Biophotonics and Robotics Volume5, Issue2
Fernando B. Avila-Rencoret, George P. Mylonas, Daniel S. Elson
#OtherInfra
Detection of YAP1 and AR-V7 mRNA for Prostate Cancer Prognosis Using an ISFET Lab-On-Chip Platform - ACS Sens
2022 Nov 11. doi: 10.1021/acssensors.2c01463.
Joseph Broomfield, Melpomeni Kalofonou, Thomas Pataillot-Meakin, Sue M Powell, Rayzel C Fernandes, Nicolas Moser, Charlotte L Bevan, Pantelis Georgiou
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SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance - Cancer Res. 2022 Nov 2;82(21):3962-3973.
Llorca-Cardenosa MJ, Aronson LI, Krastev DB, Nieminuszczy J, Alexander J, Song F, Dylewska M, Broderick R, Brough R, Zimmermann A, Zenke FT, Gurel B, Riisnaes R, Ferreira A, Roumeliotis T, Choudhary J, Pettitt SJ, de Bono J, Cervantes A, Haider S, Niedzwiedz W, Lord CJ, Chong IY.
#ClinInfra
Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells - Commun Biol 2022 Nov 11;5(1):1178.
Peter Quicke, Yilin Sun, Mar Arias-Garcia, Melina Beykou, Corey D Acker, Mustafa B A Djamgoz, Chris Bakal, Amanda J Foust
#NonClinStud
Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer - Oncogene 2022 Oct 5.
Alison Harrod, Chun-Fui Lai, Isabella Goldsbrough, Georgia M. Simmons, Natasha Oppermans, Daniela B. Santos, Balazs Győrffy, Rebecca C. Allsopp, Bradley J. Toghill, Kirsty Balachandran, Mandy Lawson, Christopher J. Morrow, Manasa Surakala, Larissa S. Carnevalli, Pei Zhang, David S. Guttery, Jacqueline A. Shaw, R. Charles Coombes, Lakjaya Buluwela, Simak Ali
#NonClinStud
Gross tumour volume radiomics for prognostication of recurrence & death following radical radiotherapy for NSCLC - NPJ Precis Oncol. 2022 Oct 27;6(1):77.
Sumeet Hindocha, Thomas G. Charlton, Kristofer Linton-Reid, Benjamin Hunter, Charleen Chan, Merina Ahmed, Emily J. Greenlay, Matthew Orton, Catey Bunce, Jason Lunn, Simon J. Doran, Shahreen Ahmad, Fiona McDonald, Imogen Locke, Danielle Power, Matthew Blackledge, Richard W. Lee & Eric O. Aboagye
#CATP
Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications - Cells. 2022 Oct 19;11(20):3286.
Naseem A, Pal A, Gowan S, Asad Y, Donovan A, Temesszentandrási-Ambrus C, Kis E, Gaborik Z, Bhalay G, Raynaud F.
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Deep-learned estimation of uncertainty in measurements of apparent diffusion coefficient from whole-body diffusion-weighted MRI - Comput Biol Med. 2022 Oct;149:106091.
Zormpas-Petridis K, Tunariu N, Collins DJ, Messiou C, Koh DM, Blackledge MD.
#ClinInfra
Optimising CT-guided biopsies of sclerotic bone lesions in cancer patients - Eur Radiol. 2022 Oct;32(10):6820-6829.
Ricardo Donners, Nicos Fotiadis, Ines Figueiredo, Matthew Blackledge, Daniel Westaby, Christina Guo, Maria de los Dolores Fenor de la Maza, Dow-Mu Koh & Nina Tunariu
#CATP #ClinInfra
Patient communication in radiology: Moving up the agenda - Eur J Radiol. 2022 Oct;155:110464.
Andrea G Rockall, Caroline Justich, Thomas Helbich, Valerie Vilgrain
#ClinInfra
Comparative efficacy of novel combination strategies for unresectable hepatocellular carcinoma: A network metanalysis of phase III trials - Eur J Cancer. 2022 Oct;174:57-67.
Claudia A M Fulgenzi, Antonio D'Alessio, Chiara Airoldi, Lorenza Scotti, Coskun O Demirtas, Alessandra Gennari, Alessio Cortellini, David J Pinato
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Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders - ACS Appl Mater Interfaces 2022 Oct 26;14(42):47445-47460.
Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie K Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michal Klosowski, Robert J Wilkinson, Roland A Fleck, Fang Xie, Alexandra E Porter, Darya Kiryushko
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The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma - Oncogene 2022 Sep 10.
Theodore Evan, Victoria Min-Yi Wang , Axel Behrens
#Affiliation
Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells - RSC Adv. 2022 Sep 15;12(40):26372-26381.
Diana Brickute, Cen Chen, Marta Braga, Chris Barnes, Ning Wang, Louis Allott, Eric O Aboagye
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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP- PROTACs) - Chem Commun (Camb). 2022 Sep 29;58(78):10933-10936.
Qisi Zhang, Cyrille S Kounde, Milon Mondal, Jake L Greenfield, Jennifer R Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D Harling, Matthew J Fuchter, Edward W Tate
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Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies - Breast Cancer Res. 2022 Sep 6;24(1):59.
Pierre-Antoine Dugué, Clara Bodelon, Felicia F. Chung, Hannah R. Brewer, Srikant Ambatipudi, Joshua N. Sampson, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Giovanni Fiorito, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Paolo Vineis, Silvia Polidoro, Laura Baglietto, Dallas English, Gianluca Severi, Graham G. Giles, Roger L. Milne, Zdenko Herceg, Montserrat Garcia-Closas, James M. Flanagan & Melissa C. Southey
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Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy - J Mater Chem B. 2022 Sep 28;10(37):7491-7511.
Srinivas Balagopal, Koichi Sasaki, Pooja Kaur, Maria Nikolaidi, Jun Ishihara
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Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma - Br J Cancer. 2022 Sep;127(5):937-947
Richard A. Noble, Huw Thomas, Yan Zhao, Lili Herendi, Rachel Howarth, Ilaria Dragoni, Hector C. Keun, Christopher P. Vellano, Joseph R. Marszalek & Stephen R. Wedge
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Structural basis for membrane attack complex inhibition by CD59 - BioRxiv 2022.09.05.506672.
Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
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Robust, single-shot, optical autofocus system utilizing cylindrical lenses to provide high precision and long range of operation - BioRxiv 2022.07.14.498938.
J. Lightley, S. Kumar, E. Garcia, Y. Alexandrov, C. Dunsby, M.A.A. Neil, P.M.W. French
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Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition - Scientific Data volume 9, Article number: 395 (2022).
Melina Beykou, Mar Arias-Garcia, Theodoros I Roumeliotis, Jyoti S Choudhary, Nicolas Moser, Pantelis Georgiou, Chris Bakal
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GREM1 is required to maintain cellular heterogeneity in pancreatic cancer - Nature volume 607, pages163–168 (2022).
Linxiang Lan, Theodore Evan, Huafu Li, Aasia Hussain, E. Josue Ruiz, May Zaw Thin, Rute M. M. Ferreira, Hari Ps, Eva M. Riising, Yoh Zen, Jorge Almagro, Kevin W. Ng, Pablo Soro-Barrio, Jessica Nelson, Gabriela Koifman, Joana Carvalho, Emma L. Nye, Yulong He, Changhua Zhang, Anguraj Sadanandam & Axel Behrens
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Microfluidic T Cell Selection by Cellular Avidity - Adv Healthc Mater 2022 Aug;11(16):e2200169.
Julian F. Ashby, Julien Schmidt, Neelima KC, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H. Au
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Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer - Clin Cancer Res. 2022 Aug 15;28(16):3509-3525.
Sowalsky AG, Figueiredo I, Lis RT, Coleman I, Gurel B, Bogdan D, Yuan W, Russo JW, Bright JR, Whitlock NC, Trostel SY, Ku AT, Patel RA, True LD, Welti J, Jimenez-Vacas JM, Rodrigues DN, Riisnaes R, Neeb A, Sprenger CT, Swain A, Wilkinson S, Karzai F, Dahut WL, Balk SP, Corey E, Nelson PS, Haffner MC, Plymate SR, de Bono JS, Sharp A.
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Capturing pore-forming intermediates of MACPF and binary toxin assemblies by cryoEM - Curr Opin Struct Biol 2022 Aug;75:102401.
Emma C Couves, Doryen Bubeck
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Variational Bayes for high-dimensional proportional hazards models with applications within gene expression - Bioinformatics. 2022 Aug 10;38(16):3918-3926.
Michael Komodromos, Eric O Aboagye, Marina Evangelou, Sarah Filippi, Kolyan Ray
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Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation - BioRviv 2022.07.21.500987
José Almeida-Santos, Rita Berkachy, Chanidapa Adele Tye, Jehanne Hassan, Bahire Kalfaoglu, Murray E. Selkirk, Masahiro Ono
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Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade - BioRvix 2022.07.19.500582.
Jehanne Hassan, Elizabeth Appleton, Bahire Kalfaoglu, Malin Pedersen, José Almeida-Santos, Hisashi Kanemaru, Nobuko Irie, Shane Foo, Omnia Reda, Benjy J.Y. Tan, Il-mi Okazaki, Taku Okazaki, Yorifumi Satou, Kevin Harrington, Alan Melcher, Masahiro Ono
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ArTisaN trial protocol: a single Centre, open-label, phase II trial of the safety and efficacy of TheraSphere selective internal radiation therapy (SIRT) in the treatment of inoperable metastatic (liver) neuroendocrine neoplasia (NENs) - BMC Cancer. 2022 Jul 20;22(1):800.
Rohini Sharma, Susanna Slater, Joanne Evans, Maria Martinez, Caroline Ward, Hooshang Izadi, Florian Wernig, Rob Thomas
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Multiparametric bone MRI can improve CT-guided bone biopsy target selection in cancer patients and increase diagnostic yield and feasibility of next-generation tumour sequencing - Eur Radiol. 2022 Jul;32(7):4647-4656.
Donners R, Figueiredo I, Tunariu N, Blackledge M, Koh DM, de la Maza MLDF, Chandran K, de Bono JS, Fotiadis N.
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The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma - Clin Cancer Res. 2022 Jul 1;28(13):2911-2922.
Zhao Cheng, Hasan Mirza, Darren P Ennis, Philip Smith, Lena Morrill Gavarró, Chishimba Sokota, Gaia Giannone, Theodora Goranova, Thomas Bradley, Anna Piskorz, Michelle Lockley; BriTROC-1 Investigators; Baljeet Kaur, Naveena Singh, Laura A Tookman, Jonathan Krell, Jacqueline McDermott, Geoffrey Macintyre, Florian Markowetz, James D Brenton, Iain A McNeish
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Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer - Clin Cancer Res. 2022 Jul 15;28(14):3104-3115.
Beshara Sheehan, Antje Neeb, Lorenzo Buroni, Alec Paschalis, Ruth Riisnaes, Bora Gurel, Veronica Gil, Susana Miranda, Mateus Crespo, Christina Guo, Juan Jiménez Vacas, Ines Figueiredo, Ana Ferreira, Jon Welti, Wei Yuan, Suzanne Carreira, Adam Sharp, Johann de Bono
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USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer - Nature Communications volume 13, Article number: 2070 (2022).
Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker & Axel Behrens
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Adenoma characteristics associated with post-polypectomy proximal colon cancer incidence: a retrospective cohort study - Br J Cancer 2022 Jun;126(12):1744-1754.
Rhea Harewood, Kate Wooldrage, Emma C Robbins, James Kinross, Christian von Wagner, Amanda J Cross
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Does the addition of whole-body MRI to routine imaging influence real-world treatment decisions in metastatic breast cancer? - Cancer Imaging. 2022 Jun 7;22(1):26.
Bhaludin BN, Tunariu N, Senthivel N, Babiker A, Soneji ND, Hujairi N, Sharma B, McGrath SE, Okines AF, Ring AE, Messiou C, Downey K, Koh DM.
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Lateral flow assays for hormone detection - Lab Chip. 2022 Jun 28;22(13):2451-2475.
Leena Khelifa, Yubing Hu, Nan Jiang, Ali K Yetisen
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Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors - J Immunother Cancer 2022 Jun;10(6):e004495.
Dionysis Papadatos-Pastos, Wei Yuan, Abhijit Pal, Mateus Crespo, Ana Ferreira, Bora Gurel, Toby Prout, Malaka Ameratunga, Maxime Chénard-Poirier, Andra Curcean, Claudia Bertan, Chloe Baker, Susana Miranda, Nahal Masrour, Wentin Chen, Rita Pereira, Ines Figueiredo, Ricardo Morilla, Ben Jenkins, Anna Zachariou, Ruth Riisnaes, Mona Parmar, Alison Turner, Suzanne Carreira, Christina Yap, Robert Brown, Nina Tunariu, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom
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Tissue architecture in tumor initiation and progression - Trends Cancer 2022 Jun;8(6):494-505.
Jorge Almagro, Hendrik A Messal, Alberto Elosegui-Artola, Jacco van Rheenen, Axel Behrens
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Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer - Nat Commun. 2022 Jun 10;13(1):3246.
R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, V. Ferguson & M. J. Seckl
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Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic Changes - Mol Cancer Ther 2022 Jun 1;21(6):1020-1029.
Elizabeth A Coker, Adam Stewart, Bugra Ozer, Anna Minchom, Lisa Pickard, Ruth Ruddle, Suzanne Carreira, Sanjay Popat, Mary O'Brien, Florence Raynaud, Johann de Bono, Bissan Al-Lazikani, Udai Banerji
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Simultaneous Depth Estimation and Surgical Tool Segmentation in Laparoscopic Images - IEEE Trans Med Robot Bionics. 2022 May;4(2):335-338.
Baoru Huang, Anh Nguyen, Siyao Wang, Ziyang Wang, Erik Mayer, David Tuch, Kunal Vyas, Stamatia Giannarou, Daniel S Elson
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Fully automated deep-learning section-based muscle segmentation from CT images for sarcopenia assessment - Clin Radiol. 2022 May;77(5):e363-e371.
S. Islam, F. Kanavati, Z. Arain, O. Fadeeva Da Costa, W. Crum, E.O. Aboagye, A.G. Rockall
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Primary radiotherapy and deep inferior epigastric perforator flap reconstruction for patients with breast cancer (PRADA): a multicentre, prospective, non-randomised, feasibility study - Lancet Oncol. 2022 May;23(5):682-690.
Paul T R Thiruchelvam, Daniel R Leff, Amy R Godden, Susan Cleator, Simon H Wood, Anna M Kirby, Navid Jallali, Navita Somaiah, Judith E Hunter, Francis P Henry, Aikaterini Micha, Rachel L O'Connell, Kabir Mohammed, Neill Patani, Melissa L H Tan, Dorothy Gujral, Gillian Ross, Stuart E James, Aadil A Khan, Jennifer E Rusby, Dimitri J Hadjiminas, Fiona A MacNeill; PRADA Trial Management Group
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Self-supervised Monocular Depth Estimation with 3D Displacement Module for Laparoscopic Images - IEEE Trans Med Robot Bionics. 2022 May;4(2):331-334.
Chi Xu, Baoru Huang, Daniel S Elson
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Risk Factors for Ovarian Cancer: An Umbrella Review of the Literature - Cancers (Basel). 2022 May 30;14(11):2708.
Eilbhe Whelan, Ilkka Kalliala, Anysia Semertzidou, Olivia Raglan, Sarah Bowden, Konstantinos Kechagias, Georgios Markozannes, Sofia Cividini, Iain McNeish, Julian Marchesi, David MacIntyre, Phillip Bennett, Kostas Tsilidis, Maria Kyrgiou
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Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care - Sci Rep. 2022 May 24;12(1):8750.
Benjamin W Wormald, Nicolas Moser, Nandita M deSouza, Katerina-Theresa Mantikas, Kenny Malpartida-Cardenas, Ivana Pennisi, Thomas E J Ind, Katherine Vroobel, Melpomeni Kalofonou, Jesus Rodriguez-Manzano, Pantelis Georgiou
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A systematic review of robotic surgery: From supervised paradigms to fully autonomous robotic approaches - Int J Med Robot 2022 Apr;18(2):e2358.
Jinpei Han, Joseph Davids, Hutan Ashrafian, Ara Darzi, Daniel S Elson, Mikael Sodergren
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Glioblastoma: Pitfalls and Opportunities of Immunotherapeutic Combinations - Onco Targets Ther. 2022 Apr 28:15:437-468.
Marcin Niedbała, Katarzyna Malarz, Gitanjali Sharma, Gabriela Kramer-Marek, Wojciech Kaspera.
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Not as simple as "fear of the unknown": A qualitative study exploring anxiety in the radiotherapy department - Eur J Cancer Care (Engl) 2022 Mar;31(2):e13564.
Eliza Gimson, Maria Greca Dottori, Gemma Clunie, Caroline Yan Zheng, Theresa Wiseman, Elizabeth Joyce, Alison McGregor, Helen McNair
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Patient and practitioner perspectives on the design of a simulated affective touch device to reduce procedural anxiety associated with radiotherapy: a qualitative study - BMJ Open. 2022 Mar 16;12(3):e050288.
Hugo Hall, Yasmin Dhuga, Caroline Yan Zheng, Gemma Clunie, Elizabeth Joyce, Helen McNair, Alison H McGregor
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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors - J Clin Invest 2022 Mar 15;132(6):e142137.
Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C Quarles, Deborah R Healey, Yijie Guo, Manuel Luis Orta-Vázquez, Santiago Mateos-Cordero, Khalid Shah, John Bomalaski, Giulio Anichini, Andreas G Tzakos, Timothy Crook, Kevin O'Neill, Adrienne C Scheck, Jose Luis Venero, Nelofer Syed
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Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity - J Extracell Vesicles. 2022 Mar;11(3):e12199.
Kai Hu, Paul F McKay, Karnyart Samnuan, Adrian Najer, Anna K Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M Stevens, Robin J Shattock
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A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer - Mol Cancer. 2022 Mar 22;21(1):82.
C E Fletcher, L Deng, F Orafidiya, W Yuan, M P G S Lorentzen, O W Cyran, A Varela-Carver, T A Constantin, D A Leach, F M Dobbs, I Figueiredo, B Gurel, E Parkes, D Bogdan, R R Pereira, S G Zhao, A Neeb, F Issa, J Hester, H Kudo, Y Liu, Y Philippou, R Bristow, K Knudsen, R J Bryant, F Y Feng, S H Reed, I G Mills, J de Bono, C L Bevan
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Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma - Nat Commun 2022 Mar 16;13(1):1380.
Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, Evon Poon, Clare Eckold, Gabriel N Valbuena, Yuewei Xu, Yusong Liu, Barbara Martins da Costa, Michael Gruet, Chiharu Wickremesinghe, Adrian Benito, Holger Kramer, Alex Montoya, David Carling, Elizabeth J Want, Yann Jamin, Louis Chesler, Hector C Keun
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A comparison of machine learning methods for predicting recurrence and death after curative-intent radiotherapy for non-small cell lung cancer: Development and validation of multivariable clinical prediction models - EBioMedicine. 2022 Mar:77:103911.
Sumeet Hindocha, Thomas G Charlton, Kristofer Linton-Reid, Benjamin Hunter, Charleen Chan, Merina Ahmed, Emily J Robinson, Matthew Orton, Shahreen Ahmad, Fiona McDonald, Imogen Locke, Danielle Power, Matthew Blackledge, Richard W Lee, Eric O Aboagye.
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The Role of Artificial Intelligence in Early Cancer Diagnosis - Cancers (Basel). 2022 Mar 16;14(6):1524.
Benjamin Hunter, Sumeet Hindocha, Richard W Lee
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CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma - J Immunother Cancer 2022 Mar;10(3):e004410.
Galabina Bozhanova, Jehanne Hassan, Lizzie Appleton, Victoria Jennings, Shane Foo, Martin McLaughlin, Charleen Ml Chan Wah Hak, Emmanuel C Patin, Eva Crespo-Rodriguez, Gabby Baker, Edward Armstrong, Matthew Chiu, Hardev Pandha, Adel Samson, Victoria Roulstone, Joan Kyula, Richard Vile, Fiona Errington-Mais, Malin Pedersen, Kevin Harrington, Masahiro Ono, Alan Melcher
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Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery - J Biomed Opt 2022 Feb;27(2):025001.
Ioannis Gkouzionis, Scarlet Nazarian, Michal Kawka, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson
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MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data - Br J Cancer. 2022 Feb;126(3):502-513.
Sharmila Rana, Gabriel N Valbuena, Ed Curry, Charlotte L Bevan, Hector C Keun
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Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy - BMC Med 2022 Jan 21;20(1):16.
Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera & Gabriela Kramer-Marek
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A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer - Annu Rev Pharmacol Toxicol. 2022 Jan 6:62:131-153.
Daniel Westaby, Maria de Los Dolores Fenor de La Maza, Alec Paschalis, Juan M Jimenez-Vacas, Jon Welti, Johann de Bono, Adam Sharp
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Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis - Elife. 2022 Jan 11:11:e72579.
Darian Williams, Marwa Mahmoud, Renfa Liu, Aitor Andueza, Sandeep Kumar, Dong-Won Kang, Jiahui Zhang, Ian Tamargo, Nicolas Villa-Roel, Kyung-In Baek, Hwakyoung Lee, Yongjin An, Leran Zhang, Edward W Tate, Pritha Bagchi, Jan Pohl, Laurent O Mosnier, Eleftherios P Diamandis, Koichiro Mihara, Morley D Hollenberg, Zhifei Dai, Hanjoong Jo
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Technologies for Size-Based Analysis of Circulating Cell-Free DNA: Limitations and Clinical Implementation - Crit Rev Oncog 2022;27(1):97-108.
Thomas Pataillot-Meakin, Sylvain Ladame, Charlotte Bevan
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HER3 Is an Actionable Target in Advanced Prostate Cancer - Cancer Res. 2021 Dec 15;81(24):6207-6218.
Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D'Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M Shen, Andrea Alimonti, Antje Neeb, Jonathan Welti, Wei Yuan, Johann de Bono; PCF/SU2C International Prostate Cancer Dream Team
Daniel Westaby, Juan M Jimenez-Vacas, Ana Padilha, Andreas Varkaris, Steven P Balk, Johann S de Bono, Adam Sharp
The systemic inflammatory response identifies patients with adverse clinical outcome from immunotherapy in hepatocellular carcinoma - Cancers (Basel). 2021 Dec 31;14(1):186.
Ambreen Muhammed, Claudia Angela Maria Fulgenzi, Sirish Dharmapuri, Matthias Pinter, Lorenz Balcar, Bernhard Scheiner, Thomas U Marron, Tomi Jun, Anwaar Saeed, Hannah Hildebrand, Mahvish Muzaffar, Musharraf Navaid, Abdul Rafeh Naqash, Anuhya Gampa, Umut Ozbek, Junk-Yi Lin, Ylenia Perone, Bruno Vincenzi, Marianna Silletta, Anjana Pillai, Yinghong Wang, Uqba Khan, Yi-Hsiang Huang, Dominik Bettinger, Yehia I Abugabal, Ahmed Kaseb, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa, Naoshi Nishida, Luca Di Tommaso, Masatoshi Kudo, Arndt Vogel, Francesco A Mauri, Alessio Cortellini, Rohini Sharma, Antonio D'Alessio, Celina Ang, David J Pinato
Strategies to implement SARS-CoV-2 point-of-care testing into primary care settings: a qualitative secondary analysis guided by the Behaviour Change Wheel - Implement Sci Commun. 2021 Dec 18;2(1):139.
Patrick Kierkegaard, Timothy Hicks, A Joy Allen, Yaling Yang, Gail Hayward, Margaret Glogowska, Brian D Nicholson, Peter Buckle; CONDOR Steering Committee
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas - Cell Stem Cell 2021 Nov 4;28(11):2000-2008.e4.
Christopher Gribben, Christopher Lambert, Hendrik A Messal, Ella-Louise Hubber, Chloe Rackham, Ian Evans, Harry Heimberg, Peter Jones, Rocio Sancho, Axel Behrens
Loop-Mediated Isothermal Amplification Assay for Detecting Tumor Markers and Human Papillomavirus: Accuracy and Supplemental Diagnostic Value to Endovaginal MRI in Cervical Cancer - Front. Oncol., 01 November 2021.
Benjamin Wormald, Jesus Rodriguez-Manzano, Nicolas Moser, Ivana Pennisi, Thomas E. J. Ind, Katherine Vroobel, Ayoma Attygalle, Pantelis Georgiou and Nandita M. deSouza
Treatment-related toxicity and improved outcome from immunotherapy in hepatocellular cancer: Evidence from an FDA pooled analysis of landmark clinical trials with validation from routine practice - Eur J Cancer. 2021 Nov;157:140-152.
David J. Pinato, Thomas U. Marron, Pallavi Shruti Mishra-Kalyani, Yutao Gong, Guo Wei, David Szafron, Elad Sharon, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Abdul R. Naqash, Thoetchai Peeraphatdit, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Chieh J. Lee, Pei-Chang Lee, Anushi Bulumulle […] Lorraine Pelosof
Efficient Table-Based Polynomial on FPGA - IEEE
Marco Barbone; Bas W. Kwaadgras; Uwe Oelfke; Wayne Luk; Georgi Gaydadjiev
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A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles - Chem Commun (Camb). 2021 Nov 4;57(88):11677-11680.
Jin Hui Teh, Marta Braga, Louis Allott, Chris Barnes, Javier Hernández-Gil, Meng-Xing Tang, Eric O Aboagye, Nicholas J Long
Development of a Structured Query Language and Natural Language Processing Algorithm to Identify Lung Nodules in a Cancer Centre - Front Med (Lausanne). 2021 Nov 4:8:748168.
Benjamin Hunter, Sara Reis, Des Campbell, Sheila Matharu, Prashanthi Ratnakumar, Luca Mercuri, Sumeet Hindocha, Hardeep Kalsi, Erik Mayer, Ben Glampson, Emily J Robinson, Bisan Al-Lazikani, Lisa Scerri, Susannah Bloch, Richard Lee
Immune Checkpoint Inhibitor and Radiotherapy-Related Pneumonitis: An Informatics Approach to Determine Real-World Incidence, Severity, Management, and Resource Implications - Front Med (Lausanne). 2021 Nov 1:8:764563.
Sumeet Hindocha, Des Campbell, Merina Ahmed, Kyriaki Giorgakoudi, Bhupinder Sharma, Nadia Yousaf, Philip Molyneaux, Benjamin Hunter, Hardeep Kalsi, Wanyuan Cui, Michael Davidson, Jaishree Bhosle, Anna Minchom, Imogen Locke, Fiona McDonald, Mary O'Brien, Sanjay Popat, Richard W Lee
Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach - PLoS One. 2021 Nov 18;16(11):e0260186.
Marta Braga, Chee Hau Leow, Javier Hernandez Gil, Jin H. Teh, Laurence Carroll, Nicholas J. Long, Meng-Xing Tang, Eric O. Aboagye
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Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed, Mathias Winkler
The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia - Genome Med. 2021 Nov 4;13(1):176.
Anita Mitra, David A. MacIntyre, Maria Paraskevaidi, Anna-Barbara Moscicki, Vishakha Mahajan, Ann Smith, Yun S. Lee, Deirdre Lyons, Evangelos Paraskevaidis, Julian R. Marchesi, Phillip R. Bennett & Maria Kyrgiou
Tissue clearing to examine tumour complexity in three dimensions - Nat Rev Cancer 2021 Nov;21(11):718-730.
Jorge Almagro, Hendrik A Messal, May Zaw Thin, Jacco van Rheenen, Axel Behrens
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