This page contains the list of publications which have been supported by the CRUK Convergence Science Centre as well as by the previous Imperial and ICR CRUK centres

 

 

2022

Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice - Nat Protoc 2022 Dec 9.

May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens 

 

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion - J Am Chem Soc

2022 Nov 22.

Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward W Tate

 

A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer - Clin Cancer Res 2022 Nov 15;CCR-22-2074.

Robert Jones, Ruth Plummer, Victor Moreno, Louise Carter, Desamparados Roda, Elena Garralda, Rebecca Kristeleit, Debashis Sarker, Tobias Arkenau, Patricia Roxburgh, Harriet S Walter, Sarah Blagden, Alan Anthoney, Barbara J Klencke, Mark M Kowalski, Udai Banerji

 

A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer - Clin Cancer Res 2022 Nov 1;28(21):4634-4641.

Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, Alvaro Ingles Garces, Andrea Biondo, Ionut-Gabriel Funingana, Martin Little, Ruth Ruddle, Florence Raynaud, Ruth Riisnaes, Bora Gurel, Sue Chua, Nina Tunariu, Joanna C Porter, Toby Prout, Mona Parmar, Anna Zachariou, Alison Turner, Ben Jenkins, Stuart McIntosh, Ed Ainscow, Anna Minchom, Juanita Lopez, Johann de Bono, Robert Jones, Emma Hall, Natalie Cook, Bristi Basu, Udai Banerji

 

Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy - J Microsc 2022 Nov;288(2):130-141.

Jonathan Lightley, Frederik Görlitz, Sunil Kumar, Ranjan Kalita, Arinbjorn Kolbeinsson, Edwin Garcia, Yuriy Alexandrov, Vicky Bousgouni, Riccardo Wysoczanski, Peter Barnes, Louise Donnelly, Chris BakalChristopher Dunsby, Mark A A Neil, Seth Flaxman, Paul M W French

 

Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin AssessmentJAMA Surg 2022 Nov 1;157(11):e223899.

Scarlet Nazarian, Ioannis Gkouzionis, Michal Kawka, Marta Jamroziak, Josephine Lloyd, Ara Darzi, Nisha Patel, Daniel S Elson, Christopher J Peters

 

Detection of YAP1 and AR-V7 mRNA for Prostate Cancer Prognosis Using an ISFET Lab-On-Chip Platform - ACS Sens 

2022 Nov 11. doi: 10.1021/acssensors.2c01463. 

Joseph Broomfield, Melpomeni Kalofonou, Thomas Pataillot-Meakin, Sue M Powell, Rayzel C Fernandes, Nicolas Moser, Charlotte L BevanPantelis Georgiou

 

Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells - Commun Biol 2022 Nov 11;5(1):1178.

Peter Quicke, Yilin Sun, Mar Arias-Garcia, Melina Beykou, Corey D Acker, Mustafa B A Djamgoz, Chris Bakal, Amanda J Foust

 

Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer - Oncogene  2022 Oct 5.

Alison Harrod, Chun-Fui Lai, Isabella Goldsbrough, Georgia M. Simmons, Natasha Oppermans, Daniela B. Santos, Balazs Győrffy, Rebecca C. Allsopp, Bradley J. Toghill, Kirsty Balachandran, Mandy Lawson, Christopher J. Morrow, Manasa Surakala, Larissa S. Carnevalli, Pei Zhang, David S. Guttery, Jacqueline A. Shaw, R. Charles Coombes, Lakjaya Buluwela, Simak Ali

 

Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative DisordersACS Appl Mater Interfaces 2022 Oct 26;14(42):47445-47460.

Corinne Morfill, Stanislava Pankratova, Pedro Machado, Nathalie K Fernando, Anna Regoutz, Federica Talamona, Alessandra Pinna, Michal Klosowski, Robert J Wilkinson, Roland A Fleck, Fang Xie, Alexandra E Porter, Darya Kiryushko

 

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma - Oncogene  2022 Sep 10.

Theodore Evan, Victoria Min-Yi Wang , Axel Behrens

 

Structural basis for membrane attack complex inhibition by CD59 - BioRxiv 2022.09.05.506672.

Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. TateDoryen Bubeck

 

Robust, single-shot, optical autofocus system utilizing cylindrical lenses to provide high precision and long range of operation - BioRxiv 2022.07.14.498938.

J. Lightley, S. Kumar, E. Garcia, Y. Alexandrov, C. Dunsby, M.A.A. Neil, P.M.W. French

 

Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition Scientific Data volume 9, Article number: 395 (2022).

Melina Beykou, Mar Arias-Garcia, Theodoros I Roumeliotis, Jyoti S Choudhary, Nicolas Moser, Pantelis GeorgiouChris Bakal

 

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer - Nature volume 607, pages163–168 (2022).

Linxiang Lan, Theodore Evan, Huafu Li, Aasia Hussain, E. Josue Ruiz, May Zaw Thin, Rute M. M. Ferreira, Hari Ps, Eva M. Riising, Yoh Zen, Jorge Almagro, Kevin W. Ng, Pablo Soro-Barrio, Jessica Nelson, Gabriela Koifman, Joana Carvalho, Emma L. Nye, Yulong He, Changhua Zhang, Anguraj Sadanandam & Axel Behrens 

 

Microfluidic T Cell Selection by Cellular Avidity - Adv Healthc Mater  2022 Aug;11(16):e2200169.

Julian F. Ashby, Julien Schmidt, Neelima KC, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H. Au

 

Capturing pore-forming intermediates of MACPF and binary toxin assemblies by cryoEM - Curr Opin Struct Biol 2022 Aug;75:102401.

Emma C CouvesDoryen Bubeck

 

Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation - BioRviv 2022.07.21.500987

José Almeida-Santos, Rita Berkachy, Chanidapa Adele Tye, Jehanne Hassan, Bahire Kalfaoglu, Murray E. Selkirk, Masahiro Ono

 

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade - BioRvix 2022.07.19.500582.

Jehanne Hassan, Elizabeth Appleton, Bahire Kalfaoglu, Malin Pedersen, José Almeida-Santos, Hisashi Kanemaru, Nobuko Irie, Shane Foo, Omnia Reda, Benjy J.Y. Tan, Il-mi Okazaki, Taku Okazaki, Yorifumi Satou, Kevin Harrington, Alan MelcherMasahiro Ono

 

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer - Nature Communications volume 13, Article number: 2070 (2022).

Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker & Axel Behrens 

 

Adenoma characteristics associated with post-polypectomy proximal colon cancer incidence: a retrospective cohort studyBr J Cancer 2022 Jun;126(12):1744-1754.

Rhea Harewood, Kate Wooldrage, Emma C Robbins, James Kinross, Christian von Wagner, Amanda J Cross

 

Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumorsJ Immunother Cancer 2022 Jun;10(6):e004495.

Dionysis Papadatos-Pastos, Wei Yuan, Abhijit Pal, Mateus Crespo, Ana Ferreira, Bora Gurel, Toby Prout, Malaka Ameratunga, Maxime Chénard-Poirier, Andra Curcean, Claudia Bertan, Chloe Baker, Susana Miranda, Nahal Masrour, Wentin Chen, Rita Pereira, Ines Figueiredo, Ricardo Morilla, Ben Jenkins, Anna Zachariou, Ruth Riisnaes, Mona Parmar, Alison Turner, Suzanne Carreira, Christina Yap, Robert Brown, Nina Tunariu, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom

 

Tissue architecture in tumor initiation and progressionTrends Cancer  2022 Jun;8(6):494-505.

Jorge Almagro, Hendrik A Messal, Alberto Elosegui-Artola, Jacco van Rheenen, Axel Behrens

 

Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic ChangesMol Cancer Ther 2022 Jun 1;21(6):1020-1029.

Elizabeth A Coker, Adam Stewart, Bugra Ozer, Anna Minchom, Lisa Pickard, Ruth Ruddle, Suzanne Carreira, Sanjay Popat, Mary O'Brien, Florence Raynaud, Johann de Bono, Bissan Al-Lazikani, Udai Banerji


A systematic review of robotic surgery: From supervised paradigms to fully autonomous robotic approaches - Int J Med Robot 2022 Apr;18(2):e2358.

Jinpei Han, Joseph Davids, Hutan Ashrafian, Ara Darzi, Daniel S Elson, Mikael Sodergren

 

Not as simple as "fear of the unknown": A qualitative study exploring anxiety in the radiotherapy department - Eur J Cancer Care (Engl) 2022 Mar;31(2):e13564.

Eliza Gimson, Maria Greca Dottori, Gemma Clunie, Caroline Yan Zheng, Theresa Wiseman, Elizabeth Joyce, Alison McGregorHelen McNair

 

Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors - J Clin Invest 2022 Mar 15;132(6):e142137.

Nabil Hajji, Juan Garcia-Revilla, Manuel Sarmiento Soto, Richard Perryman, Jake Symington, Chad C Quarles, Deborah R Healey, Yijie Guo, Manuel Luis Orta-Vázquez, Santiago Mateos-Cordero, Khalid Shah, John Bomalaski, Giulio Anichini, Andreas G Tzakos, Timothy Crook, Kevin O'Neill, Adrienne C Scheck, Jose Luis Venero, Nelofer Syed

 

Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastomaNat Commun 2022 Mar 16;13(1):1380. 

Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, Evon Poon, Clare Eckold, Gabriel N Valbuena, Yuewei Xu, Yusong Liu, Barbara Martins da Costa, Michael Gruet, Chiharu Wickremesinghe, Adrian Benito, Holger Kramer, Alex Montoya, David Carling, Elizabeth J Want, Yann Jamin, Louis Chesler, Hector C Keun

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma - J Immunother Cancer 2022 Mar;10(3):e004410.

Galabina Bozhanova, Jehanne Hassan, Lizzie Appleton, Victoria Jennings, Shane Foo, Martin McLaughlin, Charleen Ml Chan Wah Hak, Emmanuel C Patin, Eva Crespo-Rodriguez, Gabby Baker, Edward Armstrong, Matthew Chiu, Hardev Pandha, Adel Samson, Victoria Roulstone, Joan Kyula, Richard Vile, Fiona Errington-Mais, Malin Pedersen, Kevin Harrington, Masahiro OnoAlan Melcher

 

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicityJ Extracell Vesicles 2022 Mar;11(3):e12199.

Kai Hu, Paul F McKay, Karnyart Samnuan, Adrian Najer, Anna K Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M Stevens, Robin J Shattock

 

Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgeryJ Biomed Opt 2022 Feb;27(2):025001. 

Ioannis Gkouzionis, Scarlet Nazarian, Michal Kawka, Ara Darzi, Nisha Patel, Christopher J Peters, Daniel S Elson

 

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy - BMC Med 2022 Jan 21;20(1):16. 

Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera & Gabriela Kramer-Marek

 

Technologies for Size-Based Analysis of Circulating Cell-Free DNA: Limitations and Clinical ImplementationCrit Rev Oncog 2022;27(1):97-108. 

Thomas Pataillot-Meakin, Sylvain Ladame, Charlotte Bevan

2021

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas - Cell Stem Cell 2021 Nov 4;28(11):2000-2008.e4.

Christopher Gribben, Christopher Lambert, Hendrik A Messal, Ella-Louise Hubber, Chloe Rackham, Ian Evans, Harry Heimberg, Peter Jones, Rocio Sancho, Axel Behrens

 

Is tumour volume an independent predictor of outcome after radical prostatectomy for high-risk prostate cancer? -  Prostate Cancer Prostatic Dis 2021 Nov 29.

Nicholas Raison, Pol Servian, Amit Patel, Ainkaran Santhirasekaram, Andrew Smith, Maidie Yeung, Josephine Lloyd, Ethna Mannion, Andrea Rockall, Hashim Ahmed, Mathias Winkler

 

Tissue clearing to examine tumour complexity in three dimensions - Nat Rev Cancer 2021 Nov;21(11):718-730.

Jorge Almagro, Hendrik A Messal, May Zaw Thin, Jacco van Rheenen, Axel Behrens

 

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation - Nat Protoc 2021 Nov;16(11):5083-5122.

Wouter W Kallemeijn, Thomas Lanyon-Hogg, Nattawadee Panyain, Andrea Goya Grocin, Paulina Ciepla, Julia Morales-Sanfrutos, Edward W Tate

 

Implementing lateral flow devices in long-term care facilities: experiences from the Liverpool COVID-19 community testing pilot in care homes- a qualitative study - BMC Health Serv Res 2021 Oct 25;21(1):1153.

Patrick Kierkegaard, Massimo Micocci, Anna McLister, John S P Tulloch, Paula Parvulescu, Adam L Gordon, Peter Buckle

 

Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity - Trends Pharmacol Sci 2021 Oct;42(10):870-882.

Andrea Goya Grocin, Wouter W Kallemeijn, Edward W Tate

 

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma -  Elife 2021 Oct 12;10:e71596.

E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens

 

Structural basis of soluble membrane attack complex packaging for clearance - Nat Commun 2021 Oct 19;12(1):6086.

Anaïs Menny, Marie V Lukassen, Emma C Couves, Vojtech Franc, Albert J R Heck, Doryen Bubeck

 

Medication use and risk of proximal colon cancer: a systematic review of prospective studies with narrative synthesis and meta-analysis - Cancer Causes Control 2021 Oct;32(10):1047-1061.

Rhea Harewood, Ruth Disney, James Kinross, Christian von Wagner, Amanda J Cross

 

Arresting metastasis within the microcirculation - Clin Exp Metastasis 2021 Aug;38(4):337-342.

Angelos Varotsos Vrynas, Julia Perea PaizalChris BakalSam H Au

 

PD-1 Blockade for Hepatocellular Carcinoma: Current Research and Future Prospects - J Hepatocell Carcinoma  2021 Aug 5;8:887-897.

Antonio D'Alessio, Lorenza Rimassa, Alessio Cortellini, David James Pinato

 

Lipidomic Profiling of Colorectal Lesions for Real-Time Tissue Recognition and Risk-Stratification using Rapid Evaporative Ionisation Mass Spectrometry - Ann Surg 2021 Aug 13.

Sam E Mason, Eftychios Manoli, James L Alexander, Liam Poynter, Lauren Ford, Petra Paizs, Afeez Adebesin, James S McKenzie, Francesca Rosini, Rob Goldin, Ara Darzi, Zoltan TakatsJames M Kinross

 

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer - JCI Insight 2021 Jul 8;6(13):e124985.

E Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens

 

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer - Sci Transl Med 2021 Jul 14;13(602):eaba4627.

Stelios Chrysostomou, Rajat Roy, Filippo Prischi, Lucksamon Thamlikitkul, Kathryn L Chapman, Uwais Mufti, Robert Peach, Laifeng Ding, David Hancock, Christopher Moore, Miriam Molina-Arcas, Francesco Mauri, David J Pinato, Joel M Abrahams, Silvia Ottaviani, Leandro Castellano, Georgios Giamas, Jennifer Pascoe, Devmini Moonamale, Sarah Pirrie, Claire Gaunt, Lucinda Billingham, Neil M Steven, Michael Cullen, David Hrouda, Mathias Winkler, John Post, Philip Cohen, Seth J Salpeter, Vered Bar, Adi Zundelevich, Shay Golan, Dan Leibovici, Romain Lara, David R Klug, Sophia N Yaliraki, Mauricio Barahona, Yulan Wang, Julian Downward, J Mark Skehel, Maruf M U Ali, Michael J SecklOlivier E Pardo

 

A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target - ACS Chem Biol

2021 Jun 18;16(6):982-990.

Cassandra R Kennedy, Andrea Goya Grocin, Tristan Kovačič, Ravi Singh, Jennifer A Ward, Avinash R Shenoy, Edward W Tate        

 

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum - Nat Commun 2021 Jun 10;12(1):3515.

Shenglin Cai, Thomas Pataillot-Meakin, Akifumi Shibakawa, Ren Ren, Charlotte L BevanSylvain Ladame, Aleksandar P Ivanov, Joshua B Edel

 

A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer - J Am Chem Soc 2021 Jun 16;143(23):8911-8924. 

Scott Lovell, Leran Zhang, Thomas Kryza, Anna Neodo, Nathalie Bock, Elena De Vita, Elizabeth D Williams, Elisabeth Engelsberger, Congyi Xu, Alexander T Bakker, Maria Maneiro, Reiko J Tanaka, Charlotte L Bevan, Judith A Clements, Edward W Tate

 

Applications of liquid biopsy in the Pharmacological Audit Trail for anticancer drug development - Nat Rev Clin Oncol

2021 Jul;18(7):454-467.

Abhijit Pal, Rajiv Shinde, Manuel Selvi Miralles, Paul Workman, Johann de Bono

 

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 - Nature Communications 2021 Apr 6;12(1):2043.

Omar M Khan, Jorge Almagro, Jessica K Nelson, Stuart Horswell, Vesela Encheva, Kripa S Keyan, Bruce E Clurman, Ambrosius P Snijders, Axel Behrens

 

HER3 expression and MEK activation in non-small-cell lung carcinomaLung Cancer Manag 2021 Apr 9;10(2):LMT48.

Thubeena Manickavasagar, Wei Yuan, Suzanne Carreira, Bora Gurel, Susana Miranda, Ana Ferreira, Mateus Crespo, Ruth Riisnaes, Chloe Baker, Mary O'Brien, Jaishree Bhosle, Sanjay Popat, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom 

 

Robust optical autofocus system utilizing neural networks trained for extended range and time-course and automated multiwell plate imaging including single molecule localization microscopy - BioRxiv 2021.03.05.431171.

J. Lightley, F. Görlitz, S. Kumar, R. Kalita, A. Kolbeinsson, E. Garcia, Y Alexandrov, V. Bousgouni, R. Wysoczanski, P. Barnes, L. Donnelly, C. BakalC. Dunsby, M.A.A. Neil, S. Flaxman, P.M.W. French

 

Validation of Ultrasonic Harmonic Scalpel for Real-Time Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry - Anal Chem 2021 Apr 13;93(14):5906-5916.

Eftychios Manoli, Sam Mason, Lauren Ford, Afeez Adebesin, Zsolt Bodai, Ara DarziJames KinrossZoltan Takats

 

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs - Proc Natl Acad Sci U S A 2021 Apr 27;118(17):e2018229118.

Paula Saavedra-García, Monica Roman-Trufero, Hibah A Al-Sadah, Kevin Blighe, Elena López-Jiménez, Marilena Christoforou, Lucy Penfold, Daria Capece, Xiaobei Xiong, Yirun Miao, Katarzyna Parzych, Valentina S Caputo, Alexandros P Siskos, Vesela Encheva, Zijing Liu, Denise Thiel, Martin F Kaiser, Paolo Piazza, Aristeidis Chaidos, Anastasios Karadimitris, Guido Franzoso, Ambrosius P Snijders, Hector C KeunDiego A OyarzúnMauricio Barahona, Holger W Auner


Public resources for chemical probes: the journey so far and the road ahead - Future Med Chem 2021 Apr;13(8):731-747.

Albert A Antolin, Paul Workman, Bissan Al-Lazikani

 

Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays - BMJ Open

2021 Mar 19;11(3):e047163.

Patrick Kierkegaard, Anna McLister, Peter Buckle

 

Estimating the Risk of Death from COVID-19 in Adult Cancer Patients - Clin Oncol (R Coll Radiol) 2021 Mar;33(3):e172-e179.

M Williams, E Mi, K Le Calvez, J Chen, L Pakzad-Shahabi, S Dadhania, J Wang, A Ho, S Rabinowicz

 

Deconvoluting the biology and druggability of protein lipidation using chemical proteomics - Curr Opin Chem Biol 2021 Feb;60:97-112.

Ana Losada de la Lastra, Sarah Hassan, Edward W Tate

    

Determinants of physician networks: an ethnographic study examining the processes that inform patterns of collaboration and referral decision-making among physicians - BMJ Open 2021 Jan 5;11(1):e042334.

Patrick Kierkegaard, Jason Owen-Smith


Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis - Br J Cancer 2021 Jan;124(1):58-65.

Julia Perea Paizal, Sam H AuChris Bakal

 

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH - Nat Protoc 2021 Jan;16(1):239-262.

Hendrik A Messal, Jorge Almagro, May Zaw Thin, Antonio Tedeschi, Alessandro Ciccarelli, Laura Blackie, Kurt I Anderson, Irene Miguel-Aliaga, Jacco van Rheenen, Axel Behrens


Opportunities at the Interface of Network Science and Metabolic Modeling - Front Bioeng Biotechnol 2021 Jan 25;8:591049.

Varshit Dusad, Denise ThielMauricio BarahonaHector C KeunDiego A Oyarzún

2020

Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease - BMC Cancer 2020 Dec 9;20(1):1210.

Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E O'Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom

 

Evolution of kinase polypharmacology across HSP90 drug discovery - BioRxiv 2020.09.09.288936.

Albert A. Antolin, Paul A. Clarke, Ian Collins, Paul Workman, Bissan Al-Lazikani

 

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches - Sci Rep 2020 Sep 29;10(1):16000.

John F Darby, Lewis R Vidler, Peter J Simpson, Bissan Al-Lazikani, Stephen J Matthews, Swee Y Sharp, Laurence H Pearl, Swen Hoelder, Paul Workman

 

β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells - Metabolites Aug 26;10(9):346.

Adrian Benito, Nabil Hajji, Kevin O’Neill, Hector C. Keun, Nelofer Syed

 

Mass spectrometry transanal minimally invasive surgery (MS-TAMIS) to promote organ preservation in rectal cancer - Surg Endosc 2020 Aug;34(8):3618-3625.

Sam Mason, Eftychios Manoli, Liam Poynter, James Alexander, Petra Paizs, Afeez Adebesin, Robert Goldin, Ara DarziZoltan TakatsJames Kinross

 

Is it time to nationalise the pharmaceutical industry? - BMJ 2020 Mar 4;368:m769.

Mariana Mazzucato, Henry Lishi Li, Ara Darzi

 

The kinase polypharmacology landscape of clinical PARP inhibitors - Sci Rep 2020 Feb 17;10(1):2585.

Albert A Antolin, Malaka Ameratunga, Udai Banerji, Paul A Clarke, Paul Workman, Bissan Al-Lazikani

 

A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2 - Cancers (Basel) 2020 Feb 26;12(3):533.

Man-Hong Leung, Ho Tsoi, Chun Gong, Ellen Ps Man, Stefania Zona, Shang Yao, Eric W-F Lam, Ui-Soon Khoo

 

 

2019

FSP1 is a glutathione-independent ferroptosis suppressor - Nature 2019 Nov;575(7784):693-698.

Sebastian Doll, Florencio Porto Freitas, Ron Shah, Maceler Aldrovandi, Milene Costa da Silva, Irina Ingold, Andrea Goya Grocin, Thamara Nishida Xavier da Silva, Elena Panzilius, Christina H Scheel, André Mourão, Katalin Buday, Mami Sato, Jonas Wanninger, Thibaut Vignane, Vaishnavi Mohana, Markus Rehberg, Andrew Flatley, Aloys Schepers, Andreas Kurz, Daniel White, Markus Sauer, Michael Sattler, Edward William Tate, Werner Schmitz, Almut Schulze, Valerie O'Donnell, Bettina Proneth, Grzegorz M Popowicz, Derek A Pratt, José Pedro Friedmann Angeli, Marcus Conrad

 

Optical Technologies for Endoscopic Real-Time Histologic Assessment of Colorectal Polyps: A Meta-Analysis - Am J Gastroenterol 2019 Aug;114(8):1219-1230.

Sam E Mason, Liam Poynter, Zoltan TakatsAra DarziJames M Kinross

 

Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases - Cell Chem Biol  2019 Jun 20;26(6):892-900.e4.

Wouter W Kallemeijn, Gregor A Lueg, Monica Faronato, Kate Hadavizadeh, Andrea Goya Grocin, Ok-Ryul Song, Michael Howell, Dinis P Calado, Edward W Tate

 

Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A - Mol Cell Proteomics 2019 Jan;18(1):115-126.

Andrea Goya Grocin, Remigiusz A Serwa, Julia Morales Sanfrutos, Markus Ritzefeld, Edward W Tate